Literature DB >> 27117710

Mechanisms of transport of polymeric and lipidic nanoparticles across the intestinal barrier.

Ana Beloqui1, Anne des Rieux2, Véronique Préat3.   

Abstract

Unraveling the mechanisms of nanoparticle transport across the intestinal barrier is essential for designing more efficient nanoparticles for oral administration. The physicochemical parameters of the nanoparticles (e.g., size, surface charge, chemical composition) dictate nanoparticle fate across the intestinal barrier. This review aims to address the most important findings regarding polymeric and lipidic nanoparticle transport across the intestinal barrier, including the evaluation of critical physicochemical parameters of nanoparticles that affect nanocarrier interactions with the intestinal barrier.
Copyright © 2016 Elsevier B.V. All rights reserved.

Keywords:  Caco-2; Endocytosis; HT29-MTX; In vitro models; M cells; Nanoparticles; Transport mechanisms

Mesh：

Substances：

Year:  2016        PMID： 27117710     DOI： 10.1016/j.addr.2016.04.014

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  15 in total

Review 1.  Recent advances in understanding oligonucleotide aptamers and their applications as therapeutic agents.

Authors:  Khaled S Allemailem; Ahmad Almatroudi; Mohammed A Alsahli; Ghaiyda Talal Basfar; Faris Alrumaihi; Arshad Husain Rahmani; Amjad Ali Khan
Journal:  3 Biotech       Date:  2020-11-24       Impact factor: 2.406

2.  A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation.

Authors:  Ana Beloqui; David J Brayden; Per Artursson; Véronique Préat; Anne des Rieux
Journal:  Nat Protoc       Date:  2017-06-15       Impact factor: 13.491

Review 3.  Interactions of nanomaterials with ion channels and related mechanisms.

Authors:  Suhan Yin; Jia Liu; Yiyuan Kang; Yuqing Lin; Dongjian Li; Longquan Shao
Journal:  Br J Pharmacol       Date:  2019-09-04       Impact factor: 8.739

Review 4.  Identifying human and murine M cells in vitro.

Authors:  Ana Klisuric; Benjamin Thierry; Ludivine Delon; Clive A Prestidge; Rachel J Gibson
Journal:  Exp Biol Med (Maywood)       Date:  2019-03-24

Review 5.  Nanocrystals for Improving Oral Bioavailability of Drugs: Intestinal Transport Mechanisms and Influencing Factors.

Authors:  Zonghua Tian; Yaping Mai; Tingting Meng; Shijie Ma; Guojing Gou; Jianhong Yang
Journal:  AAPS PharmSciTech       Date:  2021-06-14       Impact factor: 3.246

Review 6.  Nanomedicines for renal disease: current status and future applications.

Authors:  Nazila Kamaly; John C He; Dennis A Ausiello; Omid C Farokhzad
Journal:  Nat Rev Nephrol       Date:  2016-10-31       Impact factor: 28.314

7.  Impact Of Penetratin Stereochemistry On The Oral Bioavailability Of Insulin-Loaded Solid Lipid Nanoparticles.

Authors:  Bader B Alsulays; Md Khalid Anwer; Gamal A Soliman; Sultan M Alshehri; El-Sayed Khafagy
Journal:  Int J Nanomedicine       Date:  2019-11-25

8.  Impact of copper oxide nanomaterials on differentiated and undifferentiated Caco-2 intestinal epithelial cells; assessment of cytotoxicity, barrier integrity, cytokine production and nanomaterial penetration.

Authors:  Victor C Ude; David M Brown; Luca Viale; Nilesh Kanase; Vicki Stone; Helinor J Johnston
Journal:  Part Fibre Toxicol       Date:  2017-08-23       Impact factor: 9.400

Review 9.  Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications-Focus on Prostate and Breast Cancer.

Authors:  Jörgen Elgqvist
Journal:  Int J Mol Sci       Date:  2017-05-20       Impact factor: 5.923

Review 10.  Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors.

Authors:  Susan Hua
Journal:  Front Pharmacol       Date:  2020-04-28       Impact factor: 5.810
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