Literature DB >> 27116597

Filicinic Acid Based Meroterpenoids with Anti-Epstein-Barr Virus Activities from Hypericum japonicum.

Linzhen Hu1,2, Yu Zhang2, Hucheng Zhu1, Junjun Liu1, Hua Li1, Xiao-Nian Li3, Weiguang Sun1, Junfen Zeng4, Yongbo Xue1, Yonghui Zhang1.   

Abstract

Seven filicinic acid-based meroterpenoids (1-7), possessing 6/6/11, 6/6/7/5, or 6/6/10 ring systems, were isolated from Hypericum japonicum. All of them have novel skeletons with the incorporation of sesquiterpenoid moieties to an acylated filicinic acid. Compounds 2a and 4 exhibited significant efficacy on anti-Epstein-Barr virus, with EC50 values of 0.57 and 0.49 μM, respectively. Furthermore, compounds 2a and 4 were well accommodated to the binding pocket of 2GV9 predicted by the molecular docking.

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Year:  2016        PMID： 27116597     DOI： 10.1021/acs.orglett.6b00906

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

1.  The Phytochemistry and Pharmacology of Hypericum.

Authors:  Chuan-Yun Xiao; Qing Mu; Simon Gibbons
Journal:  Prog Chem Org Nat Prod       Date:  2020

Review 2.  Biological activities of meroterpenoids isolated from different sources.

Authors:  Neeraj Kumar Fuloria; Radhika K Raheja; Kaushal H Shah; Manisha J Oza; Yogesh A Kulkarni; Vetriselvan Subramaniyan; Mahendran Sekar; Shivkanya Fuloria
Journal:  Front Pharmacol       Date:  2022-09-19       Impact factor: 5.988

3.  Discovery of acylphloroglucinol-based meroterpenoid enantiomers as KSHV inhibitors from Hypericum japonicum.

Authors:  Linzhen Hu; Yanfei Liu; Yanxing Wang; Zhenzhen Wang; Jinfeng Huang; Yongbo Xue; Junjun Liu; Zhenming Liu; Yong Chen; Yonghui Zhang
Journal:  RSC Adv       Date:  2018-07-02       Impact factor: 4.036

Review 4.  Natural Products Research in China From 2015 to 2016.

Authors:  Haishan Liu; Guoliang Zhu; Yaqin Fan; Yuqi Du; Mengmeng Lan; Yibo Xu; Weiming Zhu
Journal:  Front Chem       Date:  2018-03-20       Impact factor: 5.221

5.  Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray.

Authors:  Rongrong Wu; Zijun Le; Zhenzhen Wang; Shuying Tian; Yongbo Xue; Yong Chen; Linzhen Hu; Yonghui Zhang
Journal:  Molecules       Date:  2018-03-18       Impact factor: 4.411

6.  Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum acmosepalum.

Authors:  Jiao Wang; Mengjiao Shi; Jiajia Wang; Jin Li; Tengfei Ji
Journal:  Molecules       Date:  2018-12-23       Impact factor: 4.411

7.  Development of Provesicular Nanodelivery System of Curcumin as a Safe and Effective Antiviral Agent: Statistical Optimization, In Vitro Characterization, and Antiviral Effectiveness.

Authors:  Farid A Badria; Abdelaziz E Abdelaziz; Amira H Hassan; Abdullah A Elgazar; Eman A Mazyed
Journal:  Molecules       Date:  2020-12-01       Impact factor: 4.411

Review 8.  Natural Products and Their Derivatives against Human Herpesvirus Infection.

Authors:  Chattarin Ruchawapol; Man Yuan; Si-Min Wang; Wen-Wei Fu; Hong-Xi Xu
Journal:  Molecules       Date:  2021-10-18       Impact factor: 4.411

Review 9.  Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology.

Authors:  Mamona Nazir; Muhammad Saleem; Muhammad Imran Tousif; Muhammad Aijaz Anwar; Frank Surup; Iftikhar Ali; Daijie Wang; Nilufar Z Mamadalieva; Elham Alshammari; Mohamed L Ashour; Ahmed M Ashour; Ishtiaq Ahmed; Ivan R Green; Hidayat Hussain
Journal:  Biomolecules       Date:  2021-06-29

10.  Psiguajadials A-K: Unusual Psidium Meroterpenoids as Phosphodiesterase-4 Inhibitors from the Leaves of Psidium guajava.

Authors:  Gui-Hua Tang; Zhen Dong; Yan-Qiong Guo; Zhong-Bin Cheng; Chu-Jun Zhou; Sheng Yin
Journal:  Sci Rep       Date:  2017-04-21       Impact factor: 4.379
  10 in total

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