The surgical anatomy of the lateral femoral cutaneous nerve in the inguinal region: a meta-analysis.

PURPOSE: Several variations in the anatomy and injury of the lateral femoral cutaneous nerve (LFCN) have been studied since 1885. The aim of our study was to analyze the available data on the LFCN and find a true prevalence to help in the planning and execution of surgical procedures in the area of the pelvis, namely inguinal hernia repair.
METHODS: A search of the major medical databases was performed for LFCN anatomy. The anatomical data were collected and analyzed.
RESULTS: Twenty-four studies (n = 1,720) were included. The most common pattern of the LFCN exiting the pelvis was medial to the Sartorius as a single branch. When it exited in this pattern, it did so on average 1.90 cm medial to the anterior superior iliac spine (ASIS).
CONCLUSIONS: The LFCN and its variations are important to consider especially during inguinal hernia repair, abdominoplasty, and iliac bone grafting. We suggest maintaining a distance of 3 cm or more from the ASIS when operating to prevent injury to the LFCN.

Introduction

The lateral femoral cutaneous nerve (LFCN) of the thigh is normally a derivative of the posterior divisions of the L2 and L3 spinal nerves that travels through the pelvis heading towards the anterior superior iliac spine (ASIS). It then usually exits the lesser pelvis under the inguinal ligament (IL), anterior to the ASIS, bifurcates into an anterior and posterior division along the length of the thigh, and provides sensory innervation to the skin of the anterolateral and lateral aspects of the thigh [1].

The most common pathology associated with the LFCN is meralgia paresthetica, a condition entailing pain, a lack of sensation, or dysesthesia of the skin supplied by the LFCN [2]. Meralgia paresthetica may have numerous etiologies including pelvic inflammatory disease, pregnancy, various toxicities, tight clothing, and importantly, iatrogenic injuries from surgical procedures [3]. Detailed knowledge of variations in the pelvic exits and branching patterns of LFCN is crucial in diagnosing meralgia paresthetica, as well as avoiding injuries during surgical procedures, especially inguinal hernia repair. The incidence of nerve injury in laparoscopic inguinal hernia repair is about 2 % [4]. Although relatively a small percentage, current studies estimate that close to 20 million hernia repairs are performed annually worldwide [5].

Variations in the LFCN’s anatomy are common, with seven different points of exit from the pelvis having been observed [6]. Four of the variations can be classified into four zones relative to the ASIS, through which the LFCN may pass. These include medial to the ASIS and under the IL, medial to the ASIS and over the IL, directly over the ASIS, or lateral to the ASIS. Three more variations were found where the nerve passed through another tissue: the ASIS itself, the sartorius muscle, or the IL. Even when the nerve followed the anatomically normal exit pattern of medial to the ASIS and under the IL, the distance from the ASIS can vary, creating a zone where the LFCN can be encountered. Furthermore, five branching patterns were observed. These included the normal single nerve that would eventually bifurcate in the area of the thigh, bifurcation within the pelvis, bifurcation near the nerve’s exit from the pelvis, trifurcation, and quadrification [3].

Though many original studies have been performed on the LFCN, to our knowledge there has yet to be a comprehensive meta-analysis of all the data reported from anatomical studies around the world. With a lack of such a study and the possible clinical implications of the anatomy of the LFCN in surgery in the area of the hip or pelvis, the aim of our study was to perform a comprehensive meta-analysis on the prevalence of the reported variations in the LFCN to provide evidence-based foundation of anatomical knowledge for surgeons preparing for interventions in the area of the pelvis.

Materials and methods

Search strategy

The major electronic databases (Pubmed, EMBASE, Scopus, ScienceDirect, Web of Science, SciELO, BIOSIS, and CNKI) were extensively searched through November 2015 in order to identify all potentially eligible articles for inclusion into the meta-analysis. The search strategy used for Pubmed is summarized in Table 1. No language or date restrictions were set. Furthermore, the references of included studies were searched to identify any other potentially eligible articles. Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were strictly followed by the authors (Supplement 1) [7].

Table 1

Search strategy for Pubmed

1	((((“lateral femoral cutaneous nerve”[Title/Abstract]) OR “lateral cutaneous femoral nerve”[Title/Abstract]) OR “lateral cutaneous nerve of the thigh”[Title/Abstract]) OR “lateral cutaneous nerve of thigh”[Title/Abstract]) OR “nervus cutaneus femoris posterior”[Title/Abstract]
2	(((((((((((“anatomy”[Title/Abstract]) OR “anatomical”[Title/Abstract]) OR “variation”[Title/Abstract]) OR “variations”[Title/Abstract]) OR “distribution”[Title/Abstract]) OR “course”[Title/Abstract]) OR “division”[Title/Abstract]) OR “variant”[Title/Abstract]) OR “variants”[Title/Abstract]) OR “morphology”[Title/Abstract]) OR “morphological”[Title/Abstract]) OR “variability”[Title/Abstract]
3	1 AND 2

Eligibility assessment

Two authors (P.P. and B.M.H.) independently assessed all articles potentially eligible for inclusion into the meta-analysis. All studies which reported relevant, extractable anatomical data on the LFCN were included. The exclusion criteria were (1) case reports and case series, letters to the editor, review articles and conference abstracts, (2) studies which reported incomplete or non-extractable data, (3) studies on patients with LFCN pathologies, such as entrapment of the LFCN, which may potentially be associated with variable anatomy of the nerve, and (4) animal studies. All studies which were written in languages not spoken fluently by any of the authors were translated by medical professionals, fluent in the original language of the publication and English. In the case of any inconsistencies during the study selection process, a consensus between all the reviewers was reached, after consulting with the authors of the original study if possible.

Data extraction

Three reviewers (P.P., B.M.H. and B.S.) independently extracted data from the studies included in the meta-analysis. Data on the study type, sample size, geographical location, prevalence of the various exits of the LFCN from the pelvis, prevalence of the branching patterns of the LFCN in the pelvis and in the region of the IL, and the mean distance of the LFCN from its point of exit to the ASIS were extracted. Authors of all articles containing discrepancies in the data were contacted by email for additional information when possible.

Statistical analysis

Statistical analysis was performed by P.P. and J.R. using MetaXL version 2.0 by EpiGear International Pty Ltd (Wilston, QLD, Australia) to calculate multi-categorical pooled prevalence estimates for the various courses and branching patterns of the LCFA [8]. The morphometric data was pooled into an analysis using Comprehensive Meta-Analysis version 3.0 by Biostat (Englewood, NJ, USA). All analyses were performed by using a random effects model.

Heterogeneity among the studies included in the meta-analysis was measured using the chi square test and Higgins I2 statistic. A Cochran’s QP value of <0.10 for the chi square test was considered to be an indicator of significant heterogeneity between studies [9]. For Higgins I2, values of 0–40 % were considered as “might not be important”; 30–60 % “might indicate moderate heterogeneity”; 50–90 % “may indicate substantial heterogeneity”; and 75–100 % “may represent considerable heterogeneity” [9].

Subgroup analysis by type of study, geographical distribution, side (left vs. right) and/or a sensitivity analysis inclusive of studies with a number of lower limbs ≥100, was conducted to probe potential sources of heterogeneity. Confidence intervals were used to determine statistically significant differences between two or more groups. In the case of overlapping confidence intervals, the differences were not considered statistically significant [8].

Results

Study identification

The study identification process is summarized in Fig. 1. All major electronic databases were extensively searched to identify 196 potentially eligible articles. A further four articles were added by searching the references of all articles included in the meta-analysis. Fifty-three articles were assessed using full text for potential eligibility, of which 28 were deemed ineligible and excluded for being case studies, reviews and lacking relevant, extractable data. Twenty-four articles were finally included into the meta-analysis.

Fig. 1

PRISMA flowchart of studies included in the meta-analysis

Characteristics of included studies

The characteristics of included studies are presented in Table 2. A total of 25 studies (n = 1,720 lower limbs) were included into the meta-analysis [1, 3, 6, 10–32]. The dates of the included studies ranged from 1997 to 2015 and demonstrated a wide geographical distribution. Most studies were performed on cadavers, except the studies by Bodner et al. [10] and Zhu et al. [11] who used ultrasound and Watson et al. [12] who used magnetic resonance imaging. The study by Damarey et al. [13] included both cadaveric and imaging (ultrasound) modalities, and were thus for the purposes of this statistical analysis, consider as separate, independent samples.

Table 2

Characteristics of included studies

References	Country	Type of study	n (number of lower limbs)
Zhao et al. [32]	China	Cadaveric	100
Aszmann et al. [6]	USA	Cadaveric	104
Sürücü et al. [3]	Turkey	Cadaveric	37
De Ridder et al. [14]	Netherlands	Cadaveric	116
Hospodar et al. [15]	USA	Cadaveric	67
Murata et al. [16]	Japan	Cadaveric	205
Da Rocha et al. [17]	Brazil	Cadaveric	20
Dias Filho et al. [18]	Brazil	Cadaveric	50
Grothaus et al. [19]	USA	Cadaveric	29
Mischkowski et al. [20]	Germany	Cadaveric	34
Shin et al. [21]	Korea	Cadaveric	12
Bjurlin et al. [22]	USA	Cadaveric	22
Anloague and Huijbregts [1]	USA	Cadaveric	34
Damarey et al. [13]	France	Cadaveric	10
Damarey et al. [13]a	France	Imaging (ultrasound)	26
Doklamyai et al. [23]	Thailand	Cadaveric	85
Ropars et al. [24]	France	Cadaveric	34
Bodner et al. [10]	United Kingdom	Imaging (ultrasound)	17
Kosiyatrakul et al. [29]	Thailand	Cadaveric	96
Majkrzak et al. [30]	USA	Cadaveric	65
Ray et al. [25]	India	Cadaveric	47
Martins et al. [26]	Brazil	Cadaveric	120
Üzel et al. [27]	Turkey and Germany	Cadaveric	42
Zhu et al. [11]	China	Imaging (ultrasound)	240
Watson et al. [12]	USA	Imaging (MRI)	100
Chowdhry et al. [31]	USA	Cadaveric	50
Reinpold et al. [28]	Germany	Cadaveric	58

aSame study as the one above it, however two populations/modalities were employed and considered separate

Exits of the lateral femoral cutaneous nerve from the pelvis

A total of 18 studies (n = 1,473 lower limbs) reported data on where the LFCN exits in the pelvis. From our review, we identified seven types of exits from the pelvis: medial to the ASIS, through the IL, over the IL, directly over the ASIS, lateral to the ASIS, through the ASIS, and through the sartorius muscle (Fig. 2). The nerve was seen to most commonly exit medial to the sartorius muscle with a prevalence of 86.8 % (95 % CI 71.7–90.0). All other exit patterns were seen quite rarely, with rarest of them being over the IL, which had a pooled prevalence of only 0.9 % (95 % CI 0.0–3.6). Forest plots of the exits of the LFCN are presented in Supplement 2.

Fig. 2

Types of exits of the lateral femoral cutaneous nerve from the pelvis with calculated pooled prevalence. Type 1 medial to the sartorius (under the IL and medial to the ASIS), type 2 through the IL, type 3 over the IL, type 4 over the ASIS, type 5 lateral (or behind) the ASIS, type 6 through the ASIS, type 7 through the sartorius. All data reported as pooled prevalence in percentage with 95 % confidence intervals. PMa psoas major, PMi psoas minor, IM iliacus muscle, Sa sartorius, TFL tensor fasciae latae, IL inguinal ligament, LFCN lateral femoral cutaneous nerve, ASIS anterior superior iliac spine, QL quadratus lumborum

Subgroup analysis by geography revealed comparable results in all continents with an exit medial to the sartorius muscle being most common in all populations. However, it was seen slightly more commonly in South Americans with a pooled prevalence of 88.5 % (95 % CI 63.0–100.0) and less commonly in Europeans with a pooled prevalence of 81.1 % (95 % CI 58.4–92.4).

A sensitivity analysis was performed by including only studies >100 lower limbs to probe the sources of heterogeneity. Our analysis revealed results, which were not statistically significant and were comparable to results of our overall analysis. Further data on the exit of the LFCN in the pelvis is reported in Table 3.

Table 3

Exits of the lateral femoral cutaneous nerve

Population	Number of studies (n)	Medial to sartorius: % (95 % CI)	Through IL: % (95 % CI)	Over the IL: % (95 % CI)	Over the ASIS: % (95 % CI)	Lateral to ASIS: % (95 % CI)	Through the bone: % (95 % CI)	Through sartorius: % (95 % CI)	I 2: % (95 % CI)	Cochrane’s Q, P value
All	18 (1,473)	86.8 (71.7–90.0)	3.7 (0.2–9.4)	0.9 (0.0–3.6)	1.9 (0.0–5.6)	2.6 (0.0–6.7)	2.4 (0.0–6.4)	1.7 (0.0–5.2)	94.9 (93.2–96.2)	<0.001
Asia	5 (673)	84.4 (55.0–97.7)	3.9 (0.0–17.1)	0.9 (0.0–9.5)	6.3 (0.0–21.6)	4.0 (0.0–17.2)	0.2 (0.0–6.5)	0.2 (0.0–6.5)	97.7 (96.3–98.5)	<0.001
Europe	7 (415)	81.1 (58.4–92.4)	(7.8 (0.0–19.8)	1.2 (0.0–7.4)	1.1 (0.0–7.2)	2.4 (0.0–10.3)	5.3 (0.0–15.7)	1.1 (0.0–7.2)	93.0 (88.0–95.9)	<0.001
North America	3 (193)	86.7 (36.3–100.0)	0.5 (0.0–30.5)	0.5 (0.0–30.5)	0.5 (0.0–30.5)	1.5 (0.0–37.2)	5.5 (0.0–51.8)	4.8 (0.0–50.0)	98.2 (96.7–99.0)	<0.001
South America	3 (192)	88.5 (63.0–100.0)	3.6 (0.0–20.0)	0.5 (0.0–10.3)	0.5 (0.0–10.3)	1.6 (0.0–14.3)	0.5 (0.0–10.3)	4.6 (0.0–22.1)	93.0 (82.8–97.1)	<0.001
Sensitivity	5 (860)	80.1 (49.9–89.2)	6.7 (0.0–18.4)	0.2 (0.0 -4.4)	3.5 (0.0–12.8)	4.6 (0.0–15.0)	2.1 (0.0–10.1)	2.8 (0.0–11.6)	97.5 (96.0–98.4)	<0.001

Branching patterns of the lateral femoral cutaneous nerve

Fourteen studies (n = 993 lower limbs) reported data on the various branching patterns of the LFCN in the inguinal region. These patterns include no branching in the area of the IL, bifurcation within the pelvis, bifurcation in the area of the IL, trifurcation and quadrification of the LFCN. The LFCN most commonly demonstrated the no bifurcation pattern with a prevalence of 79.1 % (95 % CI 58.7–85.0), followed by bifurcation within the pelvis with a prevalence of 11.8 % (95 % CI 3.1–21.9). The least common branching pattern of quadrification is seen only in 1.0 % (95 % CI 0.0–4.8) of cases. Forest plots of the branching patterns of the LFCN are presented in Supplement 3.

Subgroup analysis by geography also demonstrated a lack of branching of the LFCN to be most common. However, it was more commonly seen in North Americans with a prevalence of 87.8 % (95 % CI 79.6–95.9) and was seen least commonly in South Americans and Europeans who had pooled prevalences of 67.7 % (95 % CI 27.0–96.6) and 67.2 % (95 % CI 23.7–95.8), respectively.

Sensitivity analysis performed using studies with only 100 or more lower limbs revealed results that were consistent with the overall analysis. Further data on the branching patterns of the LFCN can be found in Table 4.

Table 4

Branching patterns of the lateral femoral cutaneous nerve

Population	Number of articles (n)	No splitting: % (95 % CI)	Bifurcation within pelvis: % (95 % CI)	Bifurcation in IL area: % (95 % CI)	Trifurcation: % (95 % CI)	Quadrification: % (95 % CI)	I 2: % (95 % CI)	Cochrane’s Q, P value
All	14 (993)	79.1 (58.7–85.0)	11.8 (3.1–21.9)	3.3 (0.0–9.1)	4.8 (0.0–11.4)	1.0 (0.0–4.8)	95.1 (93.2–96.5)	<0.001
Asia	3 (425)	73.0 (16.2–100.0)	19.0 (0.0–63.4)	3.1 (0.0–32.4)	3.9 (0.0 -3 4.7)	1.1 (0.0–24.8)	98.8 (98.0–99.3)	<0.001
Europe	4 (146)	67.2 (23.7–95.8)	22.5 (0.0–56.4)	6.6 (0.0–31.2)	2.2 (0.0–20.3)	1.5 (0.0–18.0)	94.6 (89.2–97.3)	<0.001
North America	4 (232)	87.8 (79.6–95.9)	10.8 (4.1–20.4)	0.5 (0.0–3.1)	0.5 (0.0–3.1)	0.5 (0.0–3.1)	71.3 (18.2–89.9)	0.015
South America	3 (190)	67.7 (27.0–96.6)	1.2 (0.0–16.4)	5.5 (0.0–28.7)	24.7 (0.0–59.4)	1.0 (0.0–15.4)	94.9 (88.43–97.8)	<0.001
Sensitivity	4 (564)	79.4 (37.2–98.2)	10.0 (0.0–34.0)	6.8 (0.0–28.2)	3.1 (0.0–20.2)	0.7 (0.0–12.7)	98.4 (97.4–99.0)	<0.001

Distance from the point of exit of the lateral femoral cutaneous nerve to the anterior superior iliac spine

Eighteen articles (n = 1,099 lower limbs) reported morphometric data on the distance from the point of exit of the LFCN to the ASIS in cases when the LFCN passed medial to the ASIS and under the IL (the most common exit pattern). The pooled mean distance was found to be 1.90 cm (95 % CI 1.65–2.14).

Subgroup analysis by geography revealed that Europeans and North Americans had a longer distance between the LFCN exit and the ASIS with pooled mean distances of 2.32 cm (95 % CI 1.83–2.81) and 2.31 cm (95 % CI 1.54–3.09), respectively, whereas South Americans had the shortest distance of only 0.99 cm (95 % CI 0.43–1.55). Additional subgroup analysis by side revealed comparable distances on the left and right sides. Further data on the pooled mean distance from the point of exit of the LFCN to the ASIS is reported in Table 5.

Table 5

Distance from the exit of the lateral femoral cutaneous nerve to the anterior superior iliac spine

Population	Number of articles (number of limbs)	Pooled mean (cm): (95 % CI)	I 2: %
All	18 (1,099)	1.90 (1.65–2.14)	52.24
Asia	5 (459)	1.43 (0.98–1.89)	0.00
Europe	6 (166)	2.32 (1.83–2.81)	0.00
North America	5 (304)	2.31 (1.54–3.09)	0.00
South America	2 (170)	0.99 (0.43–1.55)	0.00
Left	5 (201)	1.99 (1.44–2.53)	35.49
Right	5 (110)	1.91 (1.38–2.43)	28.55
Sensitivity	15 (639)	2.00 (1.63–2.38)	21.67 %

Discussion

The variations in the anatomy of the LFCN have been known and documented for many years, with the injury to the LFCN noted as far back as 1885 [6]. The goal of our study was to collect all data available on the variations in the anatomy of the LFCN, namely its points of exit in the pelvis, branching patterns, and distance from other major structures, to provide a better understanding for surgeons operating in its vicinity.

Our analysis showed that a majority of nerves follow the pattern of exiting the pelvis anterior to the ASIS, under the IL and medial to the sartorius muscle, with an overall prevalence of 86.8 %, with subgroup analysis showing prevalences above 80 % for all groups. When the nerve exited following this pattern, medial to the ASIS and under the IL, it was usually found 1.9 cm medial to the ASIS.

The nerve usually exited as a single nerve, with an overall prevalence of 79.1 %. Bifurcation within the pelvis was the second most common pattern with a prevalence of 11.8 %. It was noted, however, that in studies from South America, there was a much higher prevalence of trifurcation than bifurcation in the pelvis, with a prevalence of 24.7 versus 1.2 %, respectively.

The most common pathology described pertaining to the LFCN is meralgia paresthetica, or pain and/or dysesthesia in the area of the lateral thigh that the nerve supplies [2]. The etiology of this pathology can be entrapment of the nerve caused by everything from physiological changes in the inguinal area, to the clothes a person wears. It is important to note that iatrogenic injury during surgery is also a common cause. Therefore, proper knowledge of the possible variations in the anatomy of the LFCN is important in the planning and execution of surgery in the vicinity of the LFCN.

Consideration of the variations in the LFCN are especially important in conducting inguinal hernia repairs. Though rare variations of the nerve travelling through the ASIS, the IL, or through the sartorius muscle may be better protected from superficial injury, the majority of patients’ LFCNs are at a risk of iatrogenic injury. Patients with early bifurcations, including those within the pelvis and in the area of the IL would be at higher risk of iatrogenic injury during surgery as there are more branches to keep track of in the area compared to the normal anatomy. Similarly, trifurcations and quadrifications of the LFCN provide more targets for accidental injury, putting populations from regions of South America where trifurcations presented with a prevalence of 24.7 % at an elevated risk.

Clinical data have shown laparoscopic inguinal hernia repair to be a safer alternative to open repair in terms of incidence of postoperative neuralgias with a relative risk ratio of 0.66 (95 % CI 0.51–0.87) when compared to open inguinal hernia repair [33]. When evaluating a laparoscopic approach, it has been suggested that staples be avoided within 1 cm of the ASIS due to the proximity of the LFCN [34]. In our subgroup analysis by geographical region, we noticed that there was very little heterogeneity for the pooled mean distances of the LFCN from the ASIS. Thus, we suspect the cause for heterogeneity in our overall analysis of distance of the LFCN from the ASIS was most likely due to the geographical differences. Our analysis revealed that South American populations had LFCNs closest to the ASIS with a mean distance of 0.99 cm (95 % CI 0.43–1.55). European and North American populations, on the other hand, had LFCN’s with mean distances of 2.32 cm (95 % CI 1.88–2.81) and 2.31 cm (95 % CI 1.54–3.09) from the ASIS, respectively. Asian populations fell in between with a mean distance of 1.43 cm (95 % CI 0.98–1.89). We would like to suggest that the dangerous zone for staples should be re-evaluated due to the fact that our data suggests that the average LFCN will pass within 1.9 cm of the ASIS and is highly variable depending on where the patient is from. With other procedures, such as aesthetic abdominoplasties, a zone of 4 cm around the ASIS has been demarcated as a potentially dangerous area requiring careful dissection and preservation, to retain proper LFCN structure and function [31].

Studies have reported that the general rule of thumb used by surgeons is approximating the LFCN as running two fingerbreadths medial to the ASIS [30]. Such a strategy however, can grossly miscalculate the location of the nerve depending on the patient as well as the surgeon’s anatomical knowledge. Ideally an imaging approach like ultrasound would help to determine the precise location of the LFCN and confirm that one of the other common variations is not present. However, if a gross estimate must be made, we would suggest 3 cm as a rule of thumb, rather than simply two fingerbreadths, as finger width can vary among the population. Based on our analysis, we ideally suggest a danger zone for all surgical procedures of about 3 cm around the ASIS, which corresponds to the upper limit of the confidence interval of the subgroup with the highest upper limit in the confidence interval (North America), and thus minimizing the risk of iatrogenic injury for the majority of the population.

Another procedure where the location of the LFCN is of particular interest is bone graft harvesting. Size of the graft, and size of incision can greatly influence the risk of injury. The current suggestions are that the grafts should be <3 cm in size and that the incisions being made should be at least 3 cm or more away from the palpable point of the ASIS [29]. This general guideline could potentially injure patients with an LFCN that is lateral to the ASIS, which was found in 2.6 % of the population studied (95 % CI 0.0–6.7). Thus we would recommend an imaging study like ultrasound before graft sampling.

A final consideration of the LFCN is for the anterior approach to hip arthroplasty. In a study in 2010, 81 % of patients reported new onset of neurapraxia in the area supplied by the LFCN after a hip resurfacing or total hip arthroplasty performed using the anterior approach [35]. The anterior approach offers many advantages over the posterior approach, which has a higher risk of dislocation, and the lateral approach, which puts the adduction function at risk [36]. With the anterior approach offering the least damage to a patient’s hip function, the loss of sensation provided by the LFCN becomes a larger concern. Current suggestions for minimally invasive anterior approaches suggest incisions running parallel to the LFCN [37]. Again, in order for this approach to be viable and the LFCN preserved, the location of the LFCN must be strictly determined, not simply estimated due to the high variability.

Our meta-analysis was limited by the variety of ways individual studies assess the anatomy of the LFCN. Though most studies follow a general pattern, new imaging studies and three-dimensional imaging may lead to some interpretation problems when comparing to older studies’ measured values. Additionally, high heterogeneity between studies, and a lack of assessment of publication bias due to a lack of statistical measure for multi-categorical prevalence, were limiting factors. According to our analysis, the clearest source of heterogeneity for measurements of the LFCN from the ASIS was geographical distribution. Whenever possible, authors were contacted for clarification and a consensus was reached with the research team to minimize bias in the collection and analysis.

We suggest further analysis of the LFCN and its variations, especially with the use of USG as a quick and effective method, to help surgeons minimize the incidence of meralgia paresthetica due to iatrogenic injury to the LFCN.

Conclusion

Current techniques and planning of safe zones for surgeries in the area of the pelvis are close estimates to the normal anatomy of the LFCN. Though the normal textbook anatomy describes the LFCN as passing out of the pelvis as a single nerve, under the IL and medial to the ASIS, countless variations are commonly encountered. Therefore, a proper understanding and re-evaluation of individual patients’ anatomy is crucial for making proper safe zones for surgery. Ideally, we would like to suggest considering the area within 3 cm from the ASIS as a danger zone in all surgical procedures. These variations, combined with the number of surgeries performed in the inguinal and hip area, namely inguinal hernia repair and hip replacement procedures, become significant in the prevention of meralgia paresthetica and iatrogenic injury. Proper knowledge of the variations possible can reduce the risk of nerve damage and improve the outcomes of procedures like inguinal hernia repair, hip arthroplasty, abdominoplasty, and iliac bone grafting.

Below is the link to the electronic supplementary material.

Supplement 1 - PRISMA 2009 Checklist (DOC 62 kb)

Supplement 2 - Forest Plots from overall meta-analysis for exits of the Lateral Femoral Cutaneous Nerve from the Pelvis (DOCX 59 kb)

Supplement 3 - Forest Plots from overall meta-analysis for the branching patterns of the Lateral Femoral Cutaneous Nerve (DOCX 42 kb)