John Calvin Coffey1, Donal Peter O'Leary, Miranda G Kiernan, Peter Faul. 1. aDepartment of Surgery, University Hospital Limerick bGraduate Entry Medical School, University of Limerick c4I Centre for Interventions in Infection, Inflammation and Immunity, University of Limerick dDepartment of Pathology, University Hospital Limerick, Limerick, Ireland.
Abstract
PURPOSE OF REVIEW: This article assesses the role of the mesentery in Crohn's disease. RECENT FINDINGS: The mesentery is centrally positioned both anatomically and physiologically. Overlapping mesenteric and submucosal mesenchymal contributions are important in the pathobiology of Crohn's disease. Mesenteric contributions explain the topographic distribution of Crohn's disease in general and mucosal disease in particular. Operative strategies that are mesenteric based (i.e. mesocolic excision) may reduce rates of postoperative recurrence. SUMMARY: The net effect of mesenteric events in Crohn's disease is pathologic. This can be targeted by operative means. VIDEO ABSTRACT: http://links.lww.com/COG/A18.
PURPOSE OF REVIEW: This article assesses the role of the mesentery in Crohn's disease. RECENT FINDINGS: The mesentery is centrally positioned both anatomically and physiologically. Overlapping mesenteric and submucosal mesenchymal contributions are important in the pathobiology of Crohn's disease. Mesenteric contributions explain the topographic distribution of Crohn's disease in general and mucosal disease in particular. Operative strategies that are mesenteric based (i.e. mesocolic excision) may reduce rates of postoperative recurrence. SUMMARY: The net effect of mesenteric events in Crohn's disease is pathologic. This can be targeted by operative means. VIDEO ABSTRACT: http://links.lww.com/COG/A18.
Authors: Éanna J Ryan; Gabriel Orsi; Michael R Boland; Adeel Zafar Syed; Ben Creavin; Michael E Kelly; Kieran Sheahan; Paul C Neary; Dara O Kavanagh; Deirdre McNamara; Des C Winter; James M O'Riordan Journal: Int J Colorectal Dis Date: 2020-01-09 Impact factor: 2.571
Authors: Waqas T Butt; Éanna J Ryan; Michael R Boland; Eilis M McCarthy; Joseph Omorogbe; Karl Hazel; Gary A Bass; Paul C Neary; Dara O Kavanagh; Deirdre McNamara; James M O'Riordan Journal: Int J Colorectal Dis Date: 2020-02-11 Impact factor: 2.571
Authors: E Garofalo; A Spinelli; G Pellino; K Flashman; M Frasson; M Carvello; N de'Angelis; A Garcia-Granero; M Harper; J Warusavitarne; M Coleman; E Espin; F Selvaggi Journal: Surg Endosc Date: 2020-04-02 Impact factor: 4.584