Markos Tesfaye1,2, Pernille Kaestel2, Mette Frahm Olsen2, Tsinuel Girma3, Daniel Yilma4, Alemseged Abdissa5, Christian Ritz2, Kim F Michaelsen2, Charlotte Hanlon6,7, Henrik Friis2. 1. Department of Psychiatry, College of Health Science, Jimma University, Jimma, Ethiopia. 2. Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark. 3. Department of Pediatrics and Child Health, College of Health Science, Jimma University, Jimma, Ethiopia. 4. Department of Internal Medicine, College of Health Science, Jimma University, Jimma, Ethiopia. 5. Department of Medical Laboratory Sciences & Pathology, College of Health Science, Jimma University, Jimma, Ethiopia. 6. Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. 7. Centre for Global Mental Health, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Abstract
OBJECTIVE: To determine the effects of lipid-based nutrient supplements (LNS) on the quality of life of people living with HIV (PLHIV) during the first 3 months of antiretroviral treatment (ART) and to investigate the effects of timing of supplementation by comparing with supplementation during the subsequent 3 months. METHODS: A randomised controlled trial was conducted in three ART clinics within public health facilities in Jimma, Ethiopia. Participants were PLHIV eligible to start ART with body mass index >17 kg/m(2) and given daily supplements of 200 g of LNS containing whey or soya either during the first 3 months or the subsequent months of ART. The outcome was measured in terms of total quality-of-life scores on the adapted version of the WHOQOL-HIV-BREF assessed at baseline, three and six months. RESULTS: Of the 282 participants, 186 (66.0%) were women. The mean age (SD) was 32.8 (±9.0) years, and the mean (SD) total quality-of-life score was 82.0 (±14.8) at baseline assessment. At 3 months, participants who received LNS showed better quality of life than those who only received ART without LNS (β = 6.2, 95% CI: 2.9: 9.6). At 6 months, there was no difference in total quality-of-life score between the early and delayed supplementation groups (β = 3.0, 95% CI: -0.4: 6.4). However, the early supplementation group showed higher scores on the social and spirituality domains than the delayed group. CONCLUSIONS:LNS given during the first three months of ART improves the quality of life of PLHIV.
RCT Entities:
OBJECTIVE: To determine the effects of lipid-based nutrient supplements (LNS) on the quality of life of people living with HIV (PLHIV) during the first 3 months of antiretroviral treatment (ART) and to investigate the effects of timing of supplementation by comparing with supplementation during the subsequent 3 months. METHODS: A randomised controlled trial was conducted in three ART clinics within public health facilities in Jimma, Ethiopia. Participants were PLHIV eligible to start ART with body mass index >17 kg/m(2) and given daily supplements of 200 g of LNS containing whey or soya either during the first 3 months or the subsequent months of ART. The outcome was measured in terms of total quality-of-life scores on the adapted version of the WHOQOL-HIV-BREF assessed at baseline, three and six months. RESULTS: Of the 282 participants, 186 (66.0%) were women. The mean age (SD) was 32.8 (±9.0) years, and the mean (SD) total quality-of-life score was 82.0 (±14.8) at baseline assessment. At 3 months, participants who received LNS showed better quality of life than those who only received ART without LNS (β = 6.2, 95% CI: 2.9: 9.6). At 6 months, there was no difference in total quality-of-life score between the early and delayed supplementation groups (β = 3.0, 95% CI: -0.4: 6.4). However, the early supplementation group showed higher scores on the social and spirituality domains than the delayed group. CONCLUSIONS: LNS given during the first three months of ART improves the quality of life of PLHIV.
Keywords:
HIV; VIH; antiretroviral treatment; calidad de vida; emplazamiento con ingresos bajos; food insecurity; inseguridad alimentaria; insécurité alimentaire; lipid-based nutrient supplement; low-income setting; quality of life; qualité vie; suplementos nutricionales de base lipídica; supplément nutritif à base de lipides; traitement antirétroviral; tratamiento antirretroviral; zone à faibles revenus