Matthew R Fusco1, Mohamed M Salem2, Bradley A Gross3, Arra S Reddy2, Christopher S Ogilvy2, Ekkehard M Kasper2, Ajith J Thomas2. 1. Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. 2. Division of Neurosurgery, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. 3. Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Abstract
OBJECTIVE: Preoperative endovascular embolization of intracranial tumors is performed to mitigate anticipated intraoperative blood loss. Although the usage of a wide array of embolic agents, particularly polyvinyl alcohol (PVA), has been described for a variety of tumors, literature detailing the efficacy, safety and complication rates for the usage of Onyx is relatively sparse. MATERIALS AND METHODS: We reviewed our single institutional experience with pre-surgical Onyx embolization of extra-axial tumors to evaluate its efficacy and safety and highlight nuances of individualized cases. RESULTS: Five patients underwent pre-surgical Onyx embolization of large or giant extra-axial tumors within 24 hours of surgical resection. Four patients harbored falcine or convexity meningiomas (grade I in 2 patients, grade II in 1 patient and grade III in one patient), and one patient had a grade II hemangiopericytoma. Embolization proceeded uneventfully in all cases and there were no complications. CONCLUSION: This series augments the expanding literature confirming the safety and efficacy of Onyx in the preoperative embolization of extra-axial tumors, underscoring its advantage of being able to attain extensive devascularization via only one supplying pedicle.
OBJECTIVE: Preoperative endovascular embolization of intracranial tumors is performed to mitigate anticipated intraoperative blood loss. Although the usage of a wide array of embolic agents, particularly polyvinyl alcohol (PVA), has been described for a variety of tumors, literature detailing the efficacy, safety and complication rates for the usage of Onyx is relatively sparse. MATERIALS AND METHODS: We reviewed our single institutional experience with pre-surgical Onyx embolization of extra-axial tumors to evaluate its efficacy and safety and highlight nuances of individualized cases. RESULTS: Five patients underwent pre-surgical Onyx embolization of large or giant extra-axial tumors within 24 hours of surgical resection. Four patients harbored falcine or convexity meningiomas (grade I in 2 patients, grade II in 1 patient and grade III in one patient), and one patient had a grade II hemangiopericytoma. Embolization proceeded uneventfully in all cases and there were no complications. CONCLUSION: This series augments the expanding literature confirming the safety and efficacy of Onyx in the preoperative embolization of extra-axial tumors, underscoring its advantage of being able to attain extensive devascularization via only one supplying pedicle.
Authors: Mohamed Samy Elhammady; Eric C Peterson; Jeremiah N Johnson; Mohammad Ali Aziz-Sultan Journal: World Neurosurg Date: 2011-11-11 Impact factor: 2.104
Authors: F Trivelatto; G S Nakiri; M Manisor; R Riva; M Al-Khawaldeh; I Kessler; C Mounayer Journal: AJNR Am J Neuroradiol Date: 2011-08-11 Impact factor: 3.825
Authors: Pankaj Gore; Nicholas Theodore; Leonardo Brasiliense; Louis J Kim; Mark Garrett; Peter Nakaji; L Fernando Gonzalez; Cameron G McDougall; Felipe C Albuquerque Journal: Neurosurgery Date: 2008-06 Impact factor: 4.654