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Literature DB >> 271143

Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia.

J D Rowley, H M Golomb, J Vardiman, S Fukuhara, C Dougherty, D Potter.

Abstract

We have previously reported on two patients with acute promyelocytic leukemia (APL) who had what appeared to be a deletion of chromosome No. 17. We now describe a third patient with APL. All three patients had a structural rearrangement involving No. 15 and No. 17. Our current interpretation of the chromosomal abnormality is that it is a reciprocal translocation, t (15;17) (q22; q21). Evidence that this is a consistent rearrangement associated with APL comes not only from our three patients, but also from two other published cases of APL, studied with banding, who also had an identical abnormality.

Entities: Disease Species

Mesh：

Year: 1977 PMID： 271143 DOI： 10.1002/ijc.2910200608

Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396

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Cited

25 in total

Review 1. Genome sequencing and cancer.

Authors: Elaine R Mardis
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2. The gene for human erythrocyte protein 4.2 maps to chromosome 15q15.

Authors: V Najfeld; S G Ballard; J Menninger; D C Ward; E E Bouhassira; R S Schwartz; R L Nagel; A C Rybicki
Journal: Am J Hum Genet Date: 1992-01 Impact factor: 11.025

3. The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias.

Authors: K Huebner; M Isobe; M Chao; M Bothwell; A H Ross; J Finan; J A Hoxie; A Sehgal; C R Buck; A Lanahan
Journal: Proc Natl Acad Sci U S A Date: 1986-03 Impact factor: 11.205

4. The origin and evolution of mutations in acute myeloid leukemia.

Authors: John S Welch; Timothy J Ley; Daniel C Link; Christopher A Miller; David E Larson; Daniel C Koboldt; Lukas D Wartman; Tamara L Lamprecht; Fulu Liu; Jun Xia; Cyriac Kandoth; Robert S Fulton; Michael D McLellan; David J Dooling; John W Wallis; Ken Chen; Christopher C Harris; Heather K Schmidt; Joelle M Kalicki-Veizer; Charles Lu; Qunyuan Zhang; Ling Lin; Michelle D O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Lucinda A Fulton; Vincent J Magrini; Sean D McGrath; Ryan T Demeter; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd N Wylie; Jason R Walker; Mark A Watson; Sharon E Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Jacqueline E Payton; Jack D Baty; Shashikant Kulkarni; Jeffery M Klco; Michael H Tomasson; Peter Westervelt; Matthew J Walter; Timothy A Graubert; John F DiPersio; Li Ding; Elaine R Mardis; Richard K Wilson
Journal: Cell Date: 2012-07-20 Impact factor: 41.582

9. Repeated complete remission in a patient with acute promyelocytic leukemia after treatment with 13-cis-retinoic acid first and with all-trans-retinoic acid in relapse.

Authors: T Haferlach; H Löffler; B Glass; W Gassmann
Journal: Clin Investig Date: 1993-10

10. The human c-ros gene (ROS) is located at chromosome region 6q16----6q22.

Authors: L Nagarajan; E Louie; Y Tsujimoto; P C Balduzzi; K Huebner; C M Croce
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia.

Review 1. Genome sequencing and cancer.

2. The gene for human erythrocyte protein 4.2 maps to chromosome 15q15.

3. The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias.

4. The origin and evolution of mutations in acute myeloid leukemia.

5. Sequencing the AML genome, transcriptome, and epigenome.

6. Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments.

7. The use of bone core biopsies for cytogenetic analysis.

8. Clinical aspects of acute myeloid leukemias of the FAB types M3 and M4Eo. The AML Cooperative Group.

9. Repeated complete remission in a patient with acute promyelocytic leukemia after treatment with 13-cis-retinoic acid first and with all-trans-retinoic acid in relapse.

10. The human c-ros gene (ROS) is located at chromosome region 6q16----6q22.