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Literature DB >> 27113371

Clinical and pathological significance of N-Myc downstream-regulated gene 2 (NDRG2) in diverse human cancers.

Wei Hu^1,2, Yang Yang², Chongxi Fan³, Zhiqiang Ma³, Chao Deng⁴, Tian Li², Jianjun Lv², Weiwei Yao², Jianyuan Gao⁵.

Abstract

Human N-Myc downstream-regulated gene 2 (NDRG2), located at chromosome 14q11.2, has been reported to be down-regulated and associated with the progression and prognosis of diverse cancers. Collectively, previous studies suggest that NDRG2 functions as a candidate tumor-suppressor gene; thus, up-regulation of NDRG2 protein might act as a promising therapeutic strategy for malignant tumors. The aim of this review was to comprehensively present the clinical and pathological significance of NDRG2 in human cancers.

Entities: Disease Gene Species

Keywords: Cancers; Clinical and pathological significance; N-Myc downstream-regulated gene 2

Mesh：

Substances：

Year: 2016 PMID： 27113371 DOI： 10.1007/s10495-016-1244-3

Source DB: PubMed Journal: Apoptosis ISSN： 1360-8185 Impact factor: 4.677

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Cited

5 in total

Clinical and pathological significance of N-Myc downstream-regulated gene 2 (NDRG2) in diverse human cancers.

1. MiR-130a/Ndrg2 Axis Inhibits the Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis.

2. NDRG2 gene copy number is not altered in colorectal carcinoma.

3. NDRG2 Sensitizes Myeloid Leukemia to Arsenic Trioxide via GSK3β-NDRG2-PP2A Complex Formation.

4. NDRG2 contributes to cisplatin sensitivity through modulation of BAK-to-Mcl-1 ratio.

5. Low NDRG2 expression predicts poor prognosis in solid tumors: A meta-analysis of cohort study.