Literature DB >> 27112957

Islet Autoantibodies.

Vito Lampasona1,2, Daniela Liberati3,4.   

Abstract

Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells. Islet antibodies, measured by sensitive and specific liquid phase assays, are the key parameters of the autoimmune response monitored for diagnostics or prognostics in patients with T1D or for disease prediction in at-risk individuals before T1D onset. Islet autoantibodies have been the main tool used to explore the natural history of T1D; this review summarizes the current knowledge about the autoantigens and the phenotype of islets autoantibodies acquired in large prospective studies from birth in children at risk of developing T1D.

Entities:  

Keywords:  Autoantibodies; GAD65; IA-2; Insulin; T1D; ZnT8

Mesh：

Substances：

Year:  2016        PMID： 27112957     DOI： 10.1007/s11892-016-0738-2

Source DB:  PubMed          Journal:  Curr Diab Rep        ISSN： 1534-4827            Impact factor:   4.810


  106 in total

1.  Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I.

Authors:  Annika Söderbergh; Anne Grethe Myhre; Olov Ekwall; Gennet Gebre-Medhin; Håkan Hedstrand; Eva Landgren; Aaro Miettinen; Petra Eskelin; Maria Halonen; Tiinamaija Tuomi; Jan Gustafsson; Eystein S Husebye; Jaakko Perheentupa; Mikhail Gylling; Michael P Manns; Fredrik Rorsman; Olle Kämpe; Thomas Nilsson
Journal:  J Clin Endocrinol Metab       Date:  2004-02       Impact factor: 5.958

Review 2.  Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays.

Authors:  Edwin Liu; George S Eisenbarth
Journal:  Clin Immunol       Date:  2007-09-27       Impact factor: 3.969

3.  IA-2 autoantibody affinity in children at risk for type 1 diabetes.

Authors:  Stephanie Krause; Ruth Chmiel; Ezio Bonifacio; Marlon Scholz; Michael Powell; Jadwiga Furmaniak; Bernard Rees Smith; Anette-G Ziegler; Peter Achenbach
Journal:  Clin Immunol       Date:  2012-10-03       Impact factor: 3.969

4.  Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies.

Authors:  G F Bottazzo; A Florin-Christensen; D Doniach
Journal:  Lancet       Date:  1974-11-30       Impact factor: 79.321

5.  Pathologic anatomy of the pancreas in juvenile diabetes mellitus.

Authors:  W Gepts
Journal:  Diabetes       Date:  1965-10       Impact factor: 9.461

6.  ss-cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

Authors:  M Gylling; T Tuomi; P Björses; S Kontiainen; J Partanen; M R Christie; M Knip; J Perheentupa; A Miettinen
Journal:  J Clin Endocrinol Metab       Date:  2000-12       Impact factor: 5.958

7.  A sensitive non-isotopic assay for GAD65 autoantibodies.

Authors:  Helen Brooking; Rossitza Ananieva-Jordanova; Clare Arnold; Marie Amoroso; Michael Powell; Corrado Betterle; Renato Zanchetta; Jadwiga Furmaniak; Bernard Rees Smith
Journal:  Clin Chim Acta       Date:  2003-05       Impact factor: 3.786

8.  Ontogeny and tissue distribution of human GAD expression.

Authors:  M I Mally; V Cirulli; T Otonkoski; G Soto; A Hayek
Journal:  Diabetes       Date:  1996-04       Impact factor: 9.461

9.  Detection of Antibodies Directed to the N-Terminal Region of GAD Is Dependent on Assay Format and Contributes to Differences in the Specificity of GAD Autoantibody Assays for Type 1 Diabetes.

Authors:  Alistair J K Williams; Vito Lampasona; Michael Schlosser; Patricia W Mueller; David L Pittman; William E Winter; Beena Akolkar; Rebecca Wyatt; Cristina Brigatti; Stephanie Krause; Peter Achenbach
Journal:  Diabetes       Date:  2015-05-13       Impact factor: 9.461

10.  Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes.

Authors:  W S Thompson; M L Pekalski; H Z Simons; D J Smyth; X Castro-Dopico; H Guo; C Guy; D B Dunger; S Arif; M Peakman; C Wallace; L S Wicker; J A Todd; R C Ferreira
Journal:  Clin Exp Immunol       Date:  2014-09       Impact factor: 4.330
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  20 in total

1.  Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes.

Authors:  Patrick Hanley; Jennifer A Sutter; Noah G Goodman; Yangzhu Du; Debora R Sekiguchi; Wenzhao Meng; Michael R Rickels; Ali Naji; Eline T Luning Prak
Journal:  Clin Immunol       Date:  2017-09-23       Impact factor: 3.969

2.  Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.

Authors:  Hanna Honkanen; Sami Oikarinen; Noora Nurminen; Olli H Laitinen; Heini Huhtala; Jussi Lehtonen; Tanja Ruokoranta; Minna M Hankaniemi; Valérie Lecouturier; Jeffrey W Almond; Sisko Tauriainen; Olli Simell; Jorma Ilonen; Riitta Veijola; Hanna Viskari; Mikael Knip; Heikki Hyöty
Journal:  Diabetologia       Date:  2017-01-09       Impact factor: 10.122

3.  Autoantibodies to the IA-2 Extracellular Domain Refine the Definition of "A+" Subtypes of Ketosis-Prone Diabetes.

Authors:  Surya N Mulukutla; Maria Acevedo-Calado; Christiane S Hampe; Massimo Pietropaolo; Ashok Balasubramanyam
Journal:  Diabetes Care       Date:  2018-10-16       Impact factor: 19.112

Review 4.  Loss of Znt8 function in diabetes mellitus: risk or benefit?

Authors:  Carla P Barragán-Álvarez; Eduardo Padilla-Camberos; Nestor F Díaz; Agustín Cota-Coronado; Claudia Hernández-Jiménez; Carlos C Bravo-Reyna; Nestor E Díaz-Martínez
Journal:  Mol Cell Biochem       Date:  2021-03-05       Impact factor: 3.396

Review 5.  Immunological biomarkers for the development and progression of type 1 diabetes.

Authors:  Chantal Mathieu; Riitta Lahesmaa; Ezio Bonifacio; Peter Achenbach; Timothy Tree
Journal:  Diabetologia       Date:  2018-09-12       Impact factor: 10.122

6.  Prevalence of Islet Autoantibodies in Type 1 Diabetes.

Authors:  Devi Dayal; Avani Hegde
Journal:  Indian J Endocrinol Metab       Date:  2017 May-Jun

Review 7.  Circulating unmethylated insulin DNA as a potential non-invasive biomarker of beta cell death in type 1 Diabetes: a review and future prospect.

Authors:  Kuo Zhang; Guigao Lin; Yanxi Han; Jiehong Xie; Jinming Li
Journal:  Clin Epigenetics       Date:  2017-04-26       Impact factor: 6.551

8.  Autoantibodies against zinc transporter 8 are related to age and metabolic state in patients with newly diagnosed autoimmune diabetes.

Authors:  Elżbieta Niechciał; Anita Rogowicz-Frontczak; Stanisław Piłaciński; Marta Fichna; Bogda Skowrońska; Piotr Fichna; Dorota Zozulińska-Ziółkiewicz
Journal:  Acta Diabetol       Date:  2018-01-11       Impact factor: 4.280

Review 9.  Abnormal T-Cell Development in the Thymus of Non-obese Diabetic Mice: Possible Relationship With the Pathogenesis of Type 1 Autoimmune Diabetes.

Authors:  Daniella A Mendes-da-Cruz; Julia P Lemos; Geraldo A Passos; Wilson Savino
Journal:  Front Endocrinol (Lausanne)       Date:  2018-07-12       Impact factor: 5.555

10.  Relationships between Islet-Specific Autoantibody Titers and the Clinical Characteristics of Patients with Diabetes Mellitus.

Authors:  Yiqian Zhang; Tong Yin; Xinlei Wang; Rongping Zhang; Jie Yuan; Yi Sun; Jing Zong; Shiwei Cui; Yunjuan Gu
Journal:  Diabetes Metab J       Date:  2020-07-21       Impact factor: 5.376
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