| Literature DB >> 27112486 |
Daigo Miyazaki1,2, Akinori Nakamura3,4, Akiyo Hineno1, Chinatsu Kobayashi1, Tomomi Kinoshita1, Kunihiro Yoshida5, Shu-Ichi Ikeda1.
Abstract
Heat-shock proteins (HSPs) have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study, we aimed to examine whether the serum levels of HSPs (HSP27, HSP70, and HSP90) are altered in patients with ALS. We included 58 patients diagnosed with ALS and 85 control individuals. Serum HSP levels of patients and controls were determined using enzyme-linked immunosorbent assay. The serum levels of HSP70 and HSP90 were significantly higher in patients than in controls. In contrast, serum levels of HSP27 did not differ significantly between the patient and control groups. Moreover, serum levels of HSP70 and HSP90 in patients remained high throughout the duration of the disease. Taken together, our findings suggest that HSPs might have a role in ALS progression throughout the course of the disease. Further studies are needed to clarify the role of HSPs in the pathogenesis of ALS.Entities:
Keywords: Amyotrophic lateral sclerosis; Heat-shock protein 70; Heat-shock protein 90; Protein mis-folding; Serum heat-shock proteins
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Year: 2016 PMID： 27112486 DOI： 10.1007/s10072-016-2582-1
Source DB: PubMed Journal: Neurol Sci ISSN： 1590-1874 Impact factor: 3.307