| Literature DB >> 27112277 |
Chih-Hua Chao1, Ju-Chien Cheng2, De-Yang Shen3, Hui-Chi Huang4, Yang-Chang Wu5, Tian-Shung Wu6.
Abstract
Phytochemical study of the methanolic root extract of Flueggea virosa allowed for the characterization of 18 non-alkaloid terpenoids. Their structures have skeletons composed of six rearranged ent-podocarpanes, 11 ent-podocarpanes, and a 3,4-seco-30-nor-friedelane. These were characterized based on 2D NMR, IR, UV, and MS spectroscopic analysis and their absolute configurations were determined by single-crystal X-ray studies, as well as by (1)H NMR spectroscopic analysis for the corresponding chiral derivatives. The isolates were evaluated for therapeutic potential against hepatitis C virus (HCV) infection to human hepatoma Huh7.5 cells.Entities:
Keywords: 3,4-seco-30-nor-Friedelane; Anti-hepatitis C virus; Euphorbiaceae; Flueggea virosa; ent-Podocarpane
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Year: 2016 PMID： 27112277 DOI： 10.1016/j.phytochem.2016.04.003
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072