Literature DB >> 27111757

Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug.

Jinyao Liu1, Yan Pang1, Jayanta Bhattacharyya1, Wenge Liu1, Isaac Weitzhandler1, Xinghai Li1, Ashutosh Chilkoti1.   

Abstract

Nanoparticles with high paclitaxel (PTX) loading and low systemic toxicity are prepared in scalable and versatile manner via one-step ring-opening polymerization of a prodrug monomer consisting of PTX that is appended to a cyclic carbonate through a hydrolysable ester linker. Initiating this monomer from a hydrophilic macroinitiator results in an amphiphilic diblock copolymer that spontaneously self-assembles into well-defined nanoparticles with tunable size.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  anticancer; nanoparticle; paclitaxel; prodrug; ring-opening polymerization

Mesh：

Substances：

Year:  2016        PMID： 27111757      PMCID： PMC5279999          DOI： 10.1002/adhm.201600230

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  37 in total

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2.  Role of drug release and liposome-mediated drug delivery in governing the therapeutic activity of liposomal mitoxantrone used to treat human A431 and LS180 solid tumors.

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3.  Supramolecular filaments containing a fixed 41% paclitaxel loading.

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4.  Well-defined diblock brush polymer-drug conjugates for sustained delivery of paclitaxel.

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Journal:  Biomater Sci       Date:  2015-02-11       Impact factor: 6.843

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7.  Tagging alcohols with cyclic carbonate: a versatile equivalent of (meth)acrylate for ring-opening polymerization.

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Review 8.  Nanoparticle therapeutics: an emerging treatment modality for cancer.

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Review 9.  Albumin-bound formulation of paclitaxel (Abraxane ABI-007) in the treatment of breast cancer.

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10.  A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models.

Authors:  Jayanta Bhattacharyya; Joseph J Bellucci; Isaac Weitzhandler; Jonathan R McDaniel; Ivan Spasojevic; Xinghai Li; Chao-Chieh Lin; Jen-Tsan Ashley Chi; Ashutosh Chilkoti
Journal:  Nat Commun       Date:  2015-08-04       Impact factor: 14.919
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  2 in total

1.  Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.

Authors:  Jayanta Bhattacharyya; Xiu-Rong Ren; Robert A Mook; Jiangbo Wang; Ivan Spasojevic; Richard T Premont; Xinghai Li; Ashutosh Chilkoti; Wei Chen
Journal:  Nanoscale       Date:  2017-08-31       Impact factor: 7.790

2.  Synthesis of poly(1,2-glycerol carbonate)-paclitaxel conjugates and their utility as a single high-dose replacement for multi-dose treatment regimens in peritoneal cancer.

Authors:  Iriny Ekladious; Rong Liu; Heng Zhang; Daniel H Foil; Daniel A Todd; Tyler N Graf; Robert F Padera; Nicholas H Oberlies; Yolonda L Colson; Mark W Grinstaff
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  2 in total

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