Literature DB >> 27111116

Genetics of Type 2 Diabetes: It Matters From Which Parent We Inherit the Risk.

Valeriya Lyssenko1, Leif Groop2, Rashmi B Prasad2.   

Abstract

Type 2 diabetes (T2D) results from a co-occurrence of genes and environmental factors. There are more than 120 genetic loci suggested to be associated with T2D, or with glucose and insulin levels in European and multi-ethnic populations. Risk of T2D is higher in the offspring if the mother rather than the father has T2D. Genetically, this can be associated with a unique parent-of-origin (PoO) transmission of risk alleles, and it relates to genetic programming during the intrauterine period, resulting in the inability to increase insulin secretion in response to increased demands imposed by insulin resistance later in life. Such PoO transmission is seen for variants in the KLF14, KCNQ1, GRB10, TCF7L2, THADA, and PEG3 genes. Here we describe T2D susceptibility genes associated with defects in insulin secretion, and thereby risk of overt T2D. This review emphasizes the need to consider distorted parental transmission of risk alleles by exploring the genetic risk of T2D.

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Year:  2016        PMID： 27111116      PMCID： PMC5275752          DOI： 10.1900/RDS.2015.12.233

Source DB:  PubMed          Journal:  Rev Diabet Stud        ISSN： 1613-6071


  64 in total

1.  Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes.

Authors:  Valeriya Lyssenko; Peter Almgren; Dragi Anevski; Roland Perfekt; Kaj Lahti; Michael Nissén; Bo Isomaa; Björn Forsen; Nils Homström; Carola Saloranta; Marja-Riitta Taskinen; Leif Groop; Tiinamaija Tuomi
Journal:  Diabetes       Date:  2005-01       Impact factor: 9.461

Review 2.  Epigenetics, brain evolution and behaviour.

Authors:  Eric B Keverne; James P Curley
Journal:  Front Neuroendocrinol       Date:  2008-03-10       Impact factor: 8.606

3.  Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism.

Authors:  G A Walford; T Green; B Neale; T Isakova; J I Rotter; S F A Grant; C S Fox; J S Pankow; J G Wilson; J B Meigs; D S Siscovick; D W Bowden; M J Daly; J C Florez
Journal:  Diabetologia       Date:  2011-10-29       Impact factor: 10.122

4.  Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families.

Authors:  M M Mahtani; E Widén; M Lehto; J Thomas; M McCarthy; J Brayer; B Bryant; G Chan; M Daly; C Forsblom; T Kanninen; A Kirby; L Kruglyak; K Munnelly; M Parkkonen; M P Reeve-Daly; A Weaver; T Brettin; G Duyk; E S Lander; L C Groop
Journal:  Nat Genet       Date:  1996-09       Impact factor: 38.330

5.  Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels.

Authors:  B Doiron; W Hu; L Norton; R A DeFronzo
Journal:  Diabetologia       Date:  2012-01-07       Impact factor: 10.122

6.  FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

Authors:  Melina Claussnitzer; Simon N Dankel; Kyoung-Han Kim; Gerald Quon; Wouter Meuleman; Christine Haugen; Viktoria Glunk; Isabel S Sousa; Jacqueline L Beaudry; Vijitha Puviindran; Nezar A Abdennur; Jannel Liu; Per-Arne Svensson; Yi-Hsiang Hsu; Daniel J Drucker; Gunnar Mellgren; Chi-Chung Hui; Hans Hauner; Manolis Kellis
Journal:  N Engl J Med       Date:  2015-08-19       Impact factor: 91.245

7.  Evaluation of allelic expression of imprinted genes in adult human blood.

Authors:  Jennifer M Frost; Dave Monk; Taita Stojilkovic-Mikic; Kathryn Woodfine; Lyn S Chitty; Adele Murrell; Philip Stanier; Gudrun E Moore
Journal:  PLoS One       Date:  2010-10-21       Impact factor: 3.240

8.  Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.

Authors:  Valeriya Lyssenko; Cecilia L F Nagorny; Michael R Erdos; Nils Wierup; Anna Jonsson; Peter Spégel; Marco Bugliani; Richa Saxena; Malin Fex; Nicolo Pulizzi; Bo Isomaa; Tiinamaija Tuomi; Peter Nilsson; Johanna Kuusisto; Jaakko Tuomilehto; Michael Boehnke; David Altshuler; Frank Sundler; Johan G Eriksson; Anne U Jackson; Markku Laakso; Piero Marchetti; Richard M Watanabe; Hindrik Mulder; Leif Groop
Journal:  Nat Genet       Date:  2008-12-07       Impact factor: 38.330

9.  The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study.

Authors:  R A Scott; C Langenberg; S J Sharp; P W Franks; O Rolandsson; D Drogan; Y T van der Schouw; U Ekelund; N D Kerrison; E Ardanaz; L Arriola; B Balkau; A Barricarte; I Barroso; B Bendinelli; J W J Beulens; H Boeing; B de Lauzon-Guillain; P Deloukas; G Fagherazzi; C Gonzalez; S J Griffin; L C Groop; J Halkjaer; J M Huerta; R Kaaks; K T Khaw; V Krogh; P M Nilsson; T Norat; K Overvad; S Panico; L Rodriguez-Suarez; D Romaguera; I Romieu; C Sacerdote; M J Sánchez; A M W Spijkerman; B Teucher; A Tjonneland; R Tumino; D L van der A; P A Wark; M I McCarthy; E Riboli; N J Wareham
Journal:  Diabetologia       Date:  2012-09-28       Impact factor: 10.122

10.  Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance.

Authors:  Ele Ferrannini; Andrea Natali; Stefania Camastra; Monica Nannipieri; Andrea Mari; Klaus-Peter Adam; Michael V Milburn; Gabi Kastenmüller; Jerzy Adamski; Tiinamaija Tuomi; Valeriya Lyssenko; Leif Groop; Walter E Gall
Journal:  Diabetes       Date:  2012-11-16       Impact factor: 9.461
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  6 in total

Review 1.  Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer.

Authors:  Benjamin D Hopkins; Marcus D Goncalves; Lewis C Cantley
Journal:  Nat Rev Endocrinol       Date:  2020-03-03       Impact factor: 43.330

2.  Interplay of Placental DNA Methylation and Maternal Insulin Sensitivity in Pregnancy.

Authors:  Marie-France Hivert; Andres Cardenas; Catherine Allard; Myriam Doyon; Camille E Powe; Patrick M Catalano; Patrice Perron; Luigi Bouchard
Journal:  Diabetes       Date:  2019-12-27       Impact factor: 9.461

3.  Mapping the Cord Blood Transcriptome of Pregnancies Affected by Early Maternal Anemia to Identify Signatures of Fetal Programming.

Authors:  Gad Hatem; Line Hjort; Olof Asplund; Daniel T R Minja; Omari Abdul Msemo; Sofie Lykke Møller; Thomas Lavstsen; Louise Groth-Grunnet; John P A Lusingu; Ola Hansson; Dirk Lund Christensen; Allan A Vaag; Isabella Artner; Thor Theander; Leif Groop; Christentze Schmiegelow; Ib Christian Bygbjerg; Rashmi B Prasad
Journal:  J Clin Endocrinol Metab       Date:  2022-04-19       Impact factor: 6.134

4.  Lipid-Associated Variants near ANGPTL3 and LPL Show Parent-of-Origin Specific Effects on Blood Lipid Levels and Obesity.

Authors:  Anna Lessmark; Gad Hatem; Györgyi Kovacs; Marta Vitai; Emma Ahlqvist; Tiinamaija Tuomi; Laszlo Koranyi; Leif Groop; Rashmi B Prasad
Journal:  Genes (Basel)       Date:  2021-12-29       Impact factor: 4.096

5.  Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects.

Authors:  Xing Jian; Gary Felsenfeld
Journal:  Nat Commun       Date:  2021-07-15       Impact factor: 14.919

Review 6.  Evidence for germline non-genetic inheritance of human phenotypes and diseases.

Authors:  Liana Senaldi; Matthew Smith-Raska
Journal:  Clin Epigenetics       Date:  2020-09-11       Impact factor: 7.259
  6 in total

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