Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Querectin Alleviates Zinc Oxide Nanoreprotoxicity in Male Albino Rats.

Literature DB >> 27111109

Querectin Alleviates Zinc Oxide Nanoreprotoxicity in Male Albino Rats.

Mohamed M A Hussein¹, Haytham A Ali², Islam M Saadeldin^3,4, Mona M Ahmed⁵.

Abstract

Zinc oxide nanopartciles (ZnONPs) involved in advanced technologies, and their wide-scale use in consumer market makes human beings more prone to the exposure to ZnONPs. The present study was undertaken to evaluate amelioration of ZnONP-induced toxicities with querectin in male albino rats. ZnONPs-treated rats showed a significant decrease in sperm cell count, sperm motility, live and normal sperms, as well as serum testosterone level. Severe histopathological damage with a significant increase in lipid peroxidation and a decrease in antioxidant enzymes activity and the GSH level were observed in the affected testis. Relative quantitative polymerase chain reaction results showed a significant decrease in antioxidant enzymes (superoxide dismutase and catalase) and a significant decrease in 3β-HSD, 17β-HSD, and Nr5A1 transcripts. Rats-administered querectin along with ZnONPs showed less toxic effects on all studied reproductive traits and mRNA transcripts. Our results suggest that querectin is beneficial for preventing or ameliorating ZnONP reproductive toxicities in males.

Entities: Chemical Disease Gene Species

Keywords: Antioxidants; Male Rats; Querectin; Sperm; Zinc Oxide Nanoparticles

Mesh：

Substances：

Year: 2016 PMID： 27111109 DOI： 10.1002/jbt.21812

Source DB: PubMed Journal: J Biochem Mol Toxicol ISSN： 1095-6670 Impact factor: 3.642

Keyword Cloud
Cited

16 in total

1. Amelioration of titanium dioxide nanoparticle reprotoxicity by the antioxidants morin and rutin.

Authors: Mohamed M A Hussein; Emad Gad; Mona M Ahmed; Ahmed H Arisha; Hasnaa F Mahdy; Ayman Abdel-Aziz Swelum; Hammed A Tukur; Islam M Saadeldin
Journal: Environ Sci Pollut Res Int Date: 2019-08-07 Impact factor: 4.223

2. Lycopene Alleviates Titanium Dioxide Nanoparticle-Induced Testicular Toxicity by Inhibiting Oxidative Stress and Apoptosis in Mice.

Authors: Xiaojia Meng; Li Li; Hongmei An; Yaxin Deng; Chunmei Ling; Tianjiao Lu; Guanling Song; Yan Wang
Journal: Biol Trace Elem Res Date: 2021-08-16 Impact factor: 3.738

3. BECLIN-1-Mediated Autophagy Suppresses Silica Nanoparticle-Induced Testicular Toxicity via the Inhibition of Caspase 8-Mediated Cell Apoptosis in Leydig Cells.

Authors: Qianru Zhang; Jason William Grunberger; Nitish Khurana; Xin Zhou; Xianyu Xu; Hamidreza Ghandehari; Fenglei Chen
Journal: Cells Date: 2022-06-07 Impact factor: 7.666

4. Palliative Effect of Resveratrol against Nanosized Iron Oxide-Induced Oxidative Stress and Steroidogenesis-Related Genes Dysregulation in Testicular Tissue of Adult Male Rats.

Authors: Mona M Ahmed; Mohamed M A Hussein; Taisir Saber; Yasmina M Abd-Elhakim
Journal: Int J Environ Res Public Health Date: 2022-07-04 Impact factor: 4.614

5. Morin ameliorates the testicular apoptosis, oxidative stress, and impact on blood-testis barrier induced by photo-extracellularly synthesized silver nanoparticles.

Authors: Ahmed Hamed Arisha; Mona M Ahmed; Mohamed A Kamel; Yasser A Attia; Mohamed M A Hussein
Journal: Environ Sci Pollut Res Int Date: 2019-08-02 Impact factor: 4.223

Review 10. Nanoparticle delivery system, highly active antiretroviral therapy, and testicular morphology: The role of stereology.

Authors: Edwin Coleridge S Naidu; Samuel Oluwaseun Olojede; Sodiq Kolawole Lawal; Carmen Olivia Rennie; Onyemaechi Okpara Azu
Journal: Pharmacol Res Perspect Date: 2021-05

Querectin Alleviates Zinc Oxide Nanoreprotoxicity in Male Albino Rats.

1. Amelioration of titanium dioxide nanoparticle reprotoxicity by the antioxidants morin and rutin.

2. Lycopene Alleviates Titanium Dioxide Nanoparticle-Induced Testicular Toxicity by Inhibiting Oxidative Stress and Apoptosis in Mice.

3. BECLIN-1-Mediated Autophagy Suppresses Silica Nanoparticle-Induced Testicular Toxicity via the Inhibition of Caspase 8-Mediated Cell Apoptosis in Leydig Cells.

4. Palliative Effect of Resveratrol against Nanosized Iron Oxide-Induced Oxidative Stress and Steroidogenesis-Related Genes Dysregulation in Testicular Tissue of Adult Male Rats.

5. Morin ameliorates the testicular apoptosis, oxidative stress, and impact on blood-testis barrier induced by photo-extracellularly synthesized silver nanoparticles.

6. Protective Impact of Edaravone Against ZnO NPs-induced Oxidative Stress in the Human Neuroblastoma SH-SY5Y Cell Line.

7. Zinc oxide nanoparticles improve testicular steroidogenesis machinery dysfunction in benzo[α]pyrene-challenged rats.

8. Zinc Oxide Nanoparticles Induced Oxidative DNA Damage, Inflammation and Apoptosis in Rat's Brain after Oral Exposure.

9. In Vitro Cytotoxicity Effects of Zinc Oxide Nanoparticles on Spermatogonia Cells.

Review 10. Nanoparticle delivery system, highly active antiretroviral therapy, and testicular morphology: The role of stereology.