BACKGROUND: Intracerebral hemorrhage (ICH) is a subtype of stroke with a severe high mortality and disability rate and accounts for about 10-15% of all strokes. The oppression and destruction by hematoma to brain tissue cause the primary brain injury. The inflammation and coagulation response after ICH would accelerate the formation of brain edema around hematoma, resulting in a more severe and durable injury. Currently, treatments for ICH are focusing on the primary injury including reducing intracranial hypertension, blood pressure control, and rehabilitation. There is a short-of-effective medical treatment for secondary inflammation and reducing brain edema in ICH patients. So, it is very important to study on the relationship between brain edema and ICH. SUMMARY: Many molecular and cellular mechanisms contribute to the formation and progress of brain edema after ICH; inhibition of brain edema provides favorable outcome of ICH. KEY MESSAGES: This review mainly discusses the pathology and mechanism of brain edema, the effects of brain edema on ICH, and the methods of treating brain edema after ICH.
BACKGROUND:Intracerebral hemorrhage (ICH) is a subtype of stroke with a severe high mortality and disability rate and accounts for about 10-15% of all strokes. The oppression and destruction by hematoma to brain tissue cause the primary brain injury. The inflammation and coagulation response after ICH would accelerate the formation of brain edema around hematoma, resulting in a more severe and durable injury. Currently, treatments for ICH are focusing on the primary injury including reducing intracranial hypertension, blood pressure control, and rehabilitation. There is a short-of-effective medical treatment for secondary inflammation and reducing brain edema in ICHpatients. So, it is very important to study on the relationship between brain edema and ICH. SUMMARY: Many molecular and cellular mechanisms contribute to the formation and progress of brain edema after ICH; inhibition of brain edema provides favorable outcome of ICH. KEY MESSAGES: This review mainly discusses the pathology and mechanism of brain edema, the effects of brain edema on ICH, and the methods of treating brain edema after ICH.
Authors: B R Shah; J M Holcomb; E M Davenport; C M Lack; J M McDaniel; D M Imphean; Y Xi; D A Rosenbaum; J E Urban; B C Wagner; A K Powers; C T Whitlow; J D Stitzel; J A Maldjian Journal: AJNR Am J Neuroradiol Date: 2020-07 Impact factor: 3.825
Authors: Jenna L Leclerc; Chris Li; Stacy Jean; Andrew S Lampert; Claudia Loyola Amador; Matthew A Diller; Emanuela Tolosano; Sylvain Doré Journal: Exp Neurol Date: 2019-02-19 Impact factor: 5.330
Authors: Daniel Agustín Godoy; Rafael A Núñez-Patiño; Andres Zorrilla-Vaca; Wendy C Ziai; J Claude Hemphill Journal: Neurocrit Care Date: 2019-08 Impact factor: 3.210