Mark B Schure1, Soo Borson2, Huong Q Nguyen3, Emily H Trittschuh4, Stephen M Thielke4, Kenneth C Pike5, Sandra G Adams6, Vincent S Fan7. 1. Department of Health and Human Development, Montana State University, PO Box 173540, Bozeman, MT 59717-3540, USA. Electronic address: mark.schure@montana.edu. 2. Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Box 356560, Seattle, WA 98195-6560, USA. 3. Kaiser Permanente Southern California, 100 S Los Robies, Pasadena, CA 91101, USA. 4. Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Box 356560, Seattle, WA 98195-6560, USA; Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA 98108, USA. 5. Office of Nursing Research, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA. 6. University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA; South Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, TX 78229, USA. 7. Health Services Research & Development, Center of Innovation VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA 98108, USA; Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
Abstract
BACKGROUND: Neurocognitive impairment has been described in COPD patients, but little is known about its relationship with physical functioning and health-related quality of life (HRQL) in this chronically ill patient group. METHODS: 301 stable COPD patients completed the Trail Making Test (TMT-A: psychomotor speed and TMT-B: executive control); 198 patients completed the Memory Impairment Screen (MIS). Standardization of TMT-A and TMT-B scores to a normative population yielded classifications of normal, borderline, or impaired cognitive status. Using multivariable regression, we examined the relationship between the TMT-A, TMT-B, and MIS with physical functioning (physical activity, 6-min walk test, and grip strength) and health-related quality of life (HRQL) measured with the Chronic Respiratory Questionnaire and the SF-36. RESULTS: Nearly 30% of patients had either borderline or impaired cognition on the TMT-A or TMT-B. Adjusted models indicated that those with either borderline or impaired cognitive functioning had weaker grip strength (TMT-A borderline: β = -2.9, P < 0.05; TMT-B borderline: β = -3.0, P < 0.05; TMT-B impaired: β = -2.5, P < 0.05) and lower scores on the mental health component summary score (MCS-SF-36 HRQOL) measure (TMT-A impaired: β = -4.7, P < 0.01). No adjusted significant associations were found for other physical functioning measures or the other HRQL measures. Impaired memory showed a significant association only with the MCS scale. CONCLUSIONS: Cognitive function was not associated with most standard indicators of physical function or most measures of HRQL in COPD patients. Both TMT-A and TMT-B were associated with weaker grip strength, and the TMT-A and MIS with poorer mental health.
BACKGROUND:Neurocognitive impairment has been described in COPDpatients, but little is known about its relationship with physical functioning and health-related quality of life (HRQL) in this chronically ill patient group. METHODS: 301 stable COPDpatients completed the Trail Making Test (TMT-A: psychomotor speed and TMT-B: executive control); 198 patients completed the Memory Impairment Screen (MIS). Standardization of TMT-A and TMT-B scores to a normative population yielded classifications of normal, borderline, or impaired cognitive status. Using multivariable regression, we examined the relationship between the TMT-A, TMT-B, and MIS with physical functioning (physical activity, 6-min walk test, and grip strength) and health-related quality of life (HRQL) measured with the Chronic Respiratory Questionnaire and the SF-36. RESULTS: Nearly 30% of patients had either borderline or impaired cognition on the TMT-A or TMT-B. Adjusted models indicated that those with either borderline or impaired cognitive functioning had weaker grip strength (TMT-A borderline: β = -2.9, P < 0.05; TMT-B borderline: β = -3.0, P < 0.05; TMT-B impaired: β = -2.5, P < 0.05) and lower scores on the mental health component summary score (MCS-SF-36 HRQOL) measure (TMT-A impaired: β = -4.7, P < 0.01). No adjusted significant associations were found for other physical functioning measures or the other HRQL measures. Impaired memory showed a significant association only with the MCS scale. CONCLUSIONS: Cognitive function was not associated with most standard indicators of physical function or most measures of HRQL in COPDpatients. Both TMT-A and TMT-B were associated with weaker grip strength, and the TMT-A and MIS with poorer mental health.
Authors: Joshua M Baruth; Maria I Lapid; Bart Clarke; Alexander Y Shin; Elizabeth J Atkinson; Jonas Eberhard; Guido Zavatta; Jörgen Åstrand Journal: Osteoporos Int Date: 2022-07-15 Impact factor: 5.071
Authors: Clayton L Cruthirds; Nicolaas E P Deutz; Rajesh Harrykissoon; Anthony J Zachria; Mariëlle P K J Engelen Journal: Clin Nutr Date: 2022-03-03 Impact factor: 7.324
Authors: Fiona A H M Cleutjens; Martijn A Spruit; Rudolf W H M Ponds; Lowie E G W Vanfleteren; Frits M E Franssen; Candy Gijsen; Jeanette B Dijkstra; Emiel F M Wouters; Daisy J A Janssen Journal: Chron Respir Dis Date: 2017-05-29 Impact factor: 2.444
Authors: Marc Miravitlles; Jesús Molina; José Antonio Quintano; Anna Campuzano; Joselín Pérez; Carlos Roncero Journal: Int J Chron Obstruct Pulmon Dis Date: 2018-03-06
Authors: Elise Wiley; Kenneth S Noguchi; Kevin Moncion; Natalie D'Isabella; Daria A Shkredova; Hanna Fang; Julie Richardson; Joy C MacDermid; Lynden Rodrigues; Marc Roig; Ada Tang Journal: Front Rehabil Sci Date: 2022-09-12
Authors: Lisa Van Wilder; Els Clays; Brecht Devleesschauwer; Peter Pype; Pauline Boeckxstaens; Diego Schrans; Delphine De Smedt Journal: BMJ Open Date: 2020-09-10 Impact factor: 2.692