| Literature DB >> 27109640 |
Valerie M Harris1, Rohan Sharma2, Joshua Cavett3, Biji T Kurien4, Ke Liu5, Kristi A Koelsch4, Astrid Rasmussen6, Lida Radfar7, David Lewis7, Donald U Stone8, C Erick Kaufman9, Shibo Li10, Barbara Segal11, Daniel J Wallace12, Michael H Weisman12, Swamy Venuturupalli12, Jennifer A Kelly6, Marta E Alarcon-Riquelme13, Bernardo Pons-Estel14, Roland Jonsson15, Xianglan Lu10, Jacques-Eric Gottenberg16, Juan-Manuel Anaya17, Deborah S Cunninghame-Graham18, Andrew J W Huang19, Michael T Brennan20, Pamela Hughes19, Ilias Alevizos21, Corinne Miceli-Richard22, Edward C Keystone23, Vivian P Bykerk24, Gideon Hirschfield25, Gang Xie26, Katherine A Siminovitch, Wan-Fai Ng27, Gunnel Nordmark28, Sara Magnusson Bucher29, Per Eriksson30, Roald Omdal31, Nelson L Rhodus32, Maureen Rischmueller33, Michael Rohrer19, Marie Wahren-Herlenius34, Torsten Witte35, Xavier Mariette22, Christopher J Lessard6, John B Harley36, Kathy L Sivils1, R Hal Scofield37.
Abstract
Primary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p=0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p=NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA. Published by Elsevier Inc.Entities:
Keywords: Klinefelter's syndrome; Sex bias; Sjögren's syndrome; X chromosome
Mesh：
Year: 2016 PMID： 27109640 PMCID： PMC4940221 DOI： 10.1016/j.clim.2016.04.002
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969