Literature DB >> 27109273

HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection.

A Ahmed1, S Rakshit1, A Vyakarnam1,2.   

Abstract

HIV infection predisposes the host to tuberculosis by impairing the hosts' immune system principally by killing and altering CD4 T-cell function. How HIV infection disrupts CD4 T-cell function, which specifically compromises host immunity to Mycobacterium tuberculosis, is poorly understood and is a critical roadblock in developing better vaccine- or immune-based strategies to control and monitor TB in HIV-infected subjects. This review considers key pathways that are altered in HIV-infected subjects that impair anti-TB immunity.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  CD4 T cell; HIV; Interferon; Tuberculosis; reactivation

Mesh：

Substances：

Year:  2016        PMID： 27109273     DOI： 10.1111/odi.12390

Source DB:  PubMed          Journal:  Oral Dis        ISSN： 1354-523X            Impact factor:   3.511


  11 in total

1.  BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA+ and IGRA- Indian adults.

Authors:  Srabanti Rakshit; Asma Ahmed; Vasista Adiga; Bharath K Sundararaj; Pravat Nalini Sahoo; John Kenneth; George D'Souza; Wesley Bonam; Christina Johnson; Kees Lmc Franken; Tom Hm Ottenhoff; Greg Finak; Raphael Gottardo; Kenneth D Stuart; Stephen C De Rosa; M Juliana McElrath; Annapurna Vyakarnam
Journal:  JCI Insight       Date:  2019-12-19

Review 2.  Chronic Immune Activation in TB/HIV Co-infection.

Authors:  Riti Sharan; Allison N Bucşan; Shashank Ganatra; Mirko Paiardini; Mahesh Mohan; Smriti Mehra; Shabaana A Khader; Deepak Kaushal
Journal:  Trends Microbiol       Date:  2020-04-22       Impact factor: 17.079

3.  Circulating HLA-DR+CD4+ effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis.

Authors:  Asma Ahmed; Vasista Adiga; Soumya Nayak; J Anto Jesuraj Uday Kumar; Chirag Dhar; Pravat Nalini Sahoo; Bharath K Sundararaj; George D Souza; Annapurna Vyakarnam
Journal:  PLoS Pathog       Date:  2018-09-19       Impact factor: 6.823

4.  Tumor Necrosis Factor-Alpha Antagonist Interferes With the Formation of Granulomatous Multinucleated Giant Cells: New Insights Into Mycobacterium tuberculosis Infection.

Authors:  Soraya Mezouar; Issa Diarra; Jean Roudier; Benoit Desnues; Jean-Louis Mege
Journal:  Front Immunol       Date:  2019-08-14       Impact factor: 7.561

5.  Polymorphisms in interferon pathway genes and risk of Mycobacterium tuberculosis infection in contacts of tuberculosis cases in Brazil.

Authors:  Juan Manuel Cubillos-Angulo; María B Arriaga; Mayla G M Melo; Elisangela C Silva; Lucia Elena Alvarado-Arnez; Alexandre S de Almeida; Milton O Moraes; Adriana S R Moreira; Jose R Lapa E Silva; Kiyoshi F Fukutani; Timothy R Sterling; Thomas R Hawn; Afrânio L Kritski; Martha M Oliveira; Bruno B Andrade
Journal:  Int J Infect Dis       Date:  2019-12-13       Impact factor: 3.623

Review 6.  Emerging patterns of regulatory T cell function in tuberculosis.

Authors:  A Ahmed; A Vyakarnam
Journal:  Clin Exp Immunol       Date:  2020-09-06       Impact factor: 4.330

7.  Implications of COVID-19 in high burden countries for HIV/TB: A systematic review of evidence.

Authors:  Jacques L Tamuzi; Birhanu T Ayele; Constance S Shumba; Olatunji O Adetokunboh; Jeannine Uwimana-Nicol; Zelalem T Haile; Joseph Inugu; Peter S Nyasulu
Journal:  BMC Infect Dis       Date:  2020-10-09       Impact factor: 3.090

Review 8.  Co-infections as Modulators of Disease Outcome: Minor Players or Major Players?

Authors:  Priti Devi; Azka Khan; Partha Chattopadhyay; Priyanka Mehta; Shweta Sahni; Sachin Sharma; Rajesh Pandey
Journal:  Front Microbiol       Date:  2021-07-06       Impact factor: 5.640

9.  Immunological non-response and low hemoglobin levels are predictors of incident tuberculosis among HIV-infected individuals on Truvada-based therapy in Botswana.

Authors:  Lucy Mupfumi; Sikhulile Moyo; Kesaobaka Molebatsi; Prisca K Thami; Motswedi Anderson; Tuelo Mogashoa; Thato Iketleng; Joseph Makhema; Richard Marlink; Ishmael Kasvosve; Max Essex; Rosemary M Musonda; Simani Gaseitsiwe
Journal:  PLoS One       Date:  2018-01-31       Impact factor: 3.240

Review 10.  Vaccine research and development: tuberculosis as a global health threat.

Authors:  Mohammed Maikudi Usman; Salmah Ismail; Teow Chong Teoh
Journal:  Cent Eur J Immunol       Date:  2017-08-08       Impact factor: 2.085
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