Literature DB >> 27106903

Could some aviation deep vein thrombosis be a form of decompression sickness?

Peter Buzzacott1, Andreas Mollerlokken2.   

Abstract

Aviation deep vein thrombosis is a challenge poorly understood in modern aviation. The aim of the present project was to determine if cabin decompression might favor formation of vascular bubbles in commercial air travelers. Thirty commercial flights were taken. Cabin pressure was noted at take-off and at every minute following, until the pressure stabilized. These time-pressure profiles were imported into the statistics program R and analyzed using the package SCUBA. Greatest pressure differentials between tissues and cabin pressures were estimated for 20, 40, 60, 80 and 120 min half-time compartments. Time to decompress ranged from 11 to 47 min. The greatest drop in cabin pressure was from 1022 to 776 mBar, equivalent to a saturated diver ascending from 2.46 msw depth. Mean pressure drop in flights >2 h duration was 193 mBar, while mean pressure drop in flights <2 h was 165 mBar. The greatest drop in pressure over 1 min was 28 mBar. Over 30 commercial flights it was found that the drop in cabin pressure was commensurate with that found to cause bubbles in man. Both the US Navy and the Royal Navy mandate far slower decompression from states of saturation, being 1.7 and 1.9 mBar/min respectively. The median overall rate of decompression found in this study was 8.5 mBar/min, five times the rate prescribed for USN saturation divers. The tissues associated with hypobaric bubble formation are likely slower than those associated with bounce diving, with 60 min a potentially useful index.

Entities:  

Keywords:  Bubbles; Decompression illness; Injury prevention

Mesh:

Year:  2016        PMID: 27106903     DOI: 10.1007/s11239-016-1368-x

Source DB:  PubMed          Journal:  J Thromb Thrombolysis        ISSN: 0929-5305            Impact factor:   2.300


  36 in total

1.  Is the rate of whole-body nitrogen elimination influenced by exercise?

Authors:  D R Pendergast; C Senf; C E G Lundgren
Journal:  Undersea Hyperb Med       Date:  2012 Jan-Feb       Impact factor: 0.698

2.  Exercise and nitric oxide prevent bubble formation: a novel approach to the prevention of decompression sickness?

Authors:  Ulrik Wisløff; Russell S Richardson; Alf O Brubakk
Journal:  J Physiol       Date:  2004-01-14       Impact factor: 5.182

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Journal:  Undersea Biomed Res       Date:  1992-07

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Authors:  L D Zhang; J F Kang; H L Xue
Journal:  Undersea Biomed Res       Date:  1991-01

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Authors:  G A Dixon; R W Krutz; J R Fischer
Journal:  Aviat Space Environ Med       Date:  1988-12

6.  An observation of venous gas emboli in divers and susceptibility to decompression sickness.

Authors:  Ian C Gawthrope; Matthew Summers; David J Macey; David A Playford
Journal:  Diving Hyperb Med       Date:  2015-03       Impact factor: 0.887

7.  Activation of coagulation system during air travel: a crossover study.

Authors:  A J M Schreijer; S C Cannegieter; J C M Meijers; S Middeldorp; H R Büller; F R Rosendaal
Journal:  Lancet       Date:  2006-03-11       Impact factor: 79.321

8.  Aerobic exercise before diving reduces venous gas bubble formation in humans.

Authors:  Zeljko Dujic; Darko Duplancic; Ivana Marinovic-Terzic; Darija Bakovic; Vladimir Ivancev; Zoran Valic; Davor Eterovic; Nadan M Petri; Ulrik Wisløff; Alf O Brubakk
Journal:  J Physiol       Date:  2004-01-30       Impact factor: 5.182

9.  Travel thrombosis: Pathomechanisms and clinical aspects.

Authors:  Tamás Sándor
Journal:  Pathophysiology       Date:  2008-11-18

10.  NOS inhibition increases bubble formation and reduces survival in sedentary but not exercised rats.

Authors:  Ulrik Wisløff; Russell S Richardson; Alf O Brubakk
Journal:  J Physiol       Date:  2003-01-15       Impact factor: 5.182

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