Literature DB >> 2710640

Formulation and stability of a beclomethasone dipropionate enema.

L M Stolk1, M Gerrits, E H Wiltink, C J Mulder, G N Tytgat.   

Abstract

A beclomethasone dipropionate (BDP) enema and a BDP/mesalazine combination enema (containing 2 mg BDP and 1 g mesalazine and 2 mg BDP, respectively per 40 ml) were formulated. BDP and mesalazine were suspended in a carbomer-water gel. No degradation of BDP was measured during the storage period of the BDP enema (4 weeks at 20 degrees C) and of the BDP/mesalazine enema (44 days at 4 degrees C, 20 degrees C and 37 degrees C, respectively). Progressive darkening of colour occurred for the BDP/mesalazine enema during storage at 20 degrees C and at 37 degrees C, probably induced by mesalazine degradation products. Only very slight colouring was observed at 4 degrees C. Hardly any precipitation of BDP and mesalazine was seen during the storage period and the enemas could easily be resuspended.

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Year:  1989        PMID： 2710640     DOI： 10.1007/BF01972910

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


  5 in total

1.  Stability of 5-aminosalicylic acid suspension.

Authors:  H A Montgomery; F M Smith; B E Scott; S J White; K B Gerald
Journal:  Am J Hosp Pharm       Date:  1986-01

2.  Treatment of distal ulcerative colitis with beclomethasone enemas: high therapeutic efficacy without endocrine side effects. A prospective, randomized, double-blind trial.

Authors:  G Bansky; H Bühler; B Stamm; W H Häcki; P Buchmann; J Müller
Journal:  Dis Colon Rectum       Date:  1987-04       Impact factor: 4.585

3.  Comparison of beclomethasone dipropionate and prednisolone 21-phosphate enemas in the treatment of ulcerative proctitis.

Authors:  H van der Heide; V van den Brandt-Gradel; G N Tytgat; E Endert; E H Wiltink; M E Schipper; W Dekker
Journal:  J Clin Gastroenterol       Date:  1988-04       Impact factor: 3.062

4.  Comparison of 5-aminosalicylic acid (3 g) and prednisolone phosphate sodium enemas (30 mg) in the treatment of distal ulcerative colitis. A prospective, randomized, double-blind trial.

Authors:  C J Mulder; G N Tytgat; E H Wiltink; H J Houthoff
Journal:  Scand J Gastroenterol       Date:  1988-10       Impact factor: 2.423

5.  Beclomethasone dipropionate enemas for treating inflammatory bowel disease without producing Cushing's syndrome or hypothalamic pituitary adrenal suppression.

Authors:  C R Kumana; T Seaton; M Meghji; M Castelli; R Benson; T Sivakumaran
Journal:  Lancet       Date:  1982-03-13       Impact factor: 79.321
  5 in total

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