Literature DB >> 27105814

Drug Delivery: Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery (Adv. Mater. 16/2016).

Yanqi Ye1,2, Jicheng Yu1,2, Chao Wang1,2, Nhu-Y Nguyen1, Glenn M Walker1, John B Buse3, Zhen Gu1,2,3.   

Abstract

A bio-responsive microneedle-based patch, integrated with a rhodamine-stained glucose-signal amplifier and calcein-AM-stained pancreatic β-cell capsules, is developed by Z. Gu and co-workers. This "smart cell patch", described on page 3115, effectively regulates the blood glucose level of type-1 diabetic mice, achieving a reduction for over 10 h. Image credit: Yanqi Ye.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  diabetes; drug delivery; microneedles; pancreatic cells; physiological signals

Year:  2016        PMID: 27105814     DOI: 10.1002/adma.201670112

Source DB:  PubMed          Journal:  Adv Mater        ISSN: 0935-9648            Impact factor:   30.849


  2 in total

1.  Stimuli-Responsive Delivery of Therapeutics for Diabetes Treatment.

Authors:  Jicheng Yu; Yuqi Zhang; Hunter Bomba; Zhen Gu
Journal:  Bioeng Transl Med       Date:  2016-10-03

2.  GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing.

Authors:  Meng Yuan; Kun Liu; Tao Jiang; Shengbo Li; Jing Chen; Zihan Wu; Wenqing Li; Rongzhi Tan; Wenying Wei; Xiaofan Yang; Honglian Dai; Zhenbing Chen
Journal:  J Nanobiotechnology       Date:  2022-03-19       Impact factor: 10.435

  2 in total

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