PURPOSE/ OBJECTIVES: To assess the feasibility and safety of an aerobic exercise intervention in patients with rectal cancer during and after neoadjuvant chemoradiotherapy (NACRT). . DESIGN: A prospective, single-group design with assessments at pre-NACRT, post-NACRT, and presurgery. . SETTING: The Cross Cancer Institute and University of Alberta in Edmonton, Canada. . SAMPLE: 18 patients with rectal cancer scheduled toreceive long-course NACRT followed by definitive surgery. . METHODS: Participants received a supervised moderate-intensity aerobic exercise program three days per week during six weeks of NACRT followed by an unsupervised aerobic exercise program for 150 minutes or more per week for 6-8 weeks prior to surgery. . MAIN RESEARCH VARIABLES: Eligibility rate, recruitment rate, follow-up rate, exercise adherence, serious adverse events, health-related fitness outcomes, and patient-reported outcomes. . FINDINGS: Follow-up rates post-NACRT were 83% for health-related fitness outcomes and 94% for patient-reported outcomes. Patients attended a median of 83% of their supervised exercise sessions and completed a mean of 222 minutes per week (SD = 155) of their unsupervised exercise. No serious adverse events were observed or reported. Most health-related fitness outcomes and patient-reported outcomes declined during NACRT and recovered after NACRT. . CONCLUSIONS:Aerobic exercise is feasible and safe for patients with rectal cancer during and after NACRT. . IMPLICATIONS FOR NURSING: Patients with rectal cancer are able to engage in moderate-intensity aerobic exercise during NACRT.
RCT Entities:
PURPOSE/ OBJECTIVES: To assess the feasibility and safety of an aerobic exercise intervention in patients with rectal cancer during and after neoadjuvant chemoradiotherapy (NACRT). . DESIGN: A prospective, single-group design with assessments at pre-NACRT, post-NACRT, and presurgery. . SETTING: The Cross Cancer Institute and University of Alberta in Edmonton, Canada. . SAMPLE: 18 patients with rectal cancer scheduled to receive long-course NACRT followed by definitive surgery. . METHODS:Participants received a supervised moderate-intensity aerobic exercise program three days per week during six weeks of NACRT followed by an unsupervised aerobic exercise program for 150 minutes or more per week for 6-8 weeks prior to surgery. . MAIN RESEARCH VARIABLES: Eligibility rate, recruitment rate, follow-up rate, exercise adherence, serious adverse events, health-related fitness outcomes, and patient-reported outcomes. . FINDINGS: Follow-up rates post-NACRT were 83% for health-related fitness outcomes and 94% for patient-reported outcomes. Patients attended a median of 83% of their supervised exercise sessions and completed a mean of 222 minutes per week (SD = 155) of their unsupervised exercise. No serious adverse events were observed or reported. Most health-related fitness outcomes and patient-reported outcomes declined during NACRT and recovered after NACRT. . CONCLUSIONS: Aerobic exercise is feasible and safe for patients with rectal cancer during and after NACRT. . IMPLICATIONS FOR NURSING: Patients with rectal cancer are able to engage in moderate-intensity aerobic exercise during NACRT.
Entities:
Keywords:
cancer survivor; chemotherapy; exercise; physical functioning; quality of life; radiation therapy
Authors: Andria R Morielli; Nawaid Usmani; Normand G Boulé; Diane Severin; Keith Tankel; Tirath Nijjar; Kurian Joseph; Kerry S Courneya Journal: Support Care Cancer Date: 2016-02-04 Impact factor: 3.603
Authors: Lisa Loughney; Malcolm A West; Michael P W Grocott; Sandy Jack; Helen Moyses; Andrew Bates; Graham J Kemp; Lesley Hawkins; Judit Varkonyi-Sepp; Shaunna Burke; Christopher P Barben; Peter M Calverley; Trevor Cox; Daniel H Palmer; Michael G Mythen Journal: Perioper Med (Lond) Date: 2021-06-22