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Literature DB >> 27105109

Role of EZH2 histone methyltrasferase in melanoma progression and metastasis.

Fade Mahmoud¹, Bradley Shields², Issam Makhoul¹, Laura F Hutchins¹, Sara C Shalin³, Alan J Tackett².

Abstract

There is accumulating evidence that the histone methyltransferase enhancer of zeste homolog 2 (EZH2), the main component of the polycomb-repressive complex 2 (PRC2), is involved in melanoma progression and metastasis. Novel drugs that target and reverse such epigenetic changes may find a way into the management of patients with advanced melanoma. We provide a comprehensive up-to-date review of the role and biology of EZH2 on gene transcription, senescence/apoptosis, melanoma microenvironment, melanocyte stem cells, the immune system, and micro RNA. Furthermore, we discuss EZH2 inhibitors as potential anti-cancer therapy.

Entities: Disease Gene Species

Keywords: Chromatin; EZH2; H3K27 trimethylation; epigenetic changes; histone; melanoma; polycomb-repressive complex

Mesh：

Substances：

Year: 2016 PMID： 27105109 PMCID： PMC4990393 DOI： 10.1080/15384047.2016.1167291

Source DB: PubMed Journal: Cancer Biol Ther ISSN： 1538-4047 Impact factor: 4.742

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