BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder. Epidemiological studies on the incidence of PD are important to better understand the risk factors for PD and determine the condition's natural history. OBJECTIVE: This systematic review and meta-analysis examine the incidence of PD and its variation by age and gender. METHODS: We searched MEDLINE and EMBASE for epidemiologic studies of PD from 2001 to 2014, as a previously published systematic review included studies published until 2001. Data were analyzed separately for age group and gender, and meta-regression was used to determine whether a significant difference was present between groups. RESULTS: Twenty-seven studies were included in the analysis. Meta-analysis of international studies showed rising incidence with age in both men and women. Significant heterogeneity was observed in the 80+ group, which may be explained by methodological differences between studies. While males had a higher incidence of PD in all age groups, this difference was only statistically significant for those in the age range 60-69 and 70-79 (p < 0.05). CONCLUSION: PD incidence generally increases with age, although it may stabilize in those who are 80+.
BACKGROUND:Parkinson's disease (PD) is a common neurodegenerative disorder. Epidemiological studies on the incidence of PD are important to better understand the risk factors for PD and determine the condition's natural history. OBJECTIVE: This systematic review and meta-analysis examine the incidence of PD and its variation by age and gender. METHODS: We searched MEDLINE and EMBASE for epidemiologic studies of PD from 2001 to 2014, as a previously published systematic review included studies published until 2001. Data were analyzed separately for age group and gender, and meta-regression was used to determine whether a significant difference was present between groups. RESULTS: Twenty-seven studies were included in the analysis. Meta-analysis of international studies showed rising incidence with age in both men and women. Significant heterogeneity was observed in the 80+ group, which may be explained by methodological differences between studies. While males had a higher incidence of PD in all age groups, this difference was only statistically significant for those in the age range 60-69 and 70-79 (p < 0.05). CONCLUSION:PD incidence generally increases with age, although it may stabilize in those who are 80+.
Authors: James W S Young; Rinku Sutradhar; Jagadish Rangrej; Connie Marras; Neil Fleshner; Shabbir M H Alibhai Journal: World J Urol Date: 2017-02-15 Impact factor: 4.226
Authors: Caroline A Mulvaney; Gonçalo S Duarte; Joel Handley; David Jw Evans; Suresh Menon; Richard Wyse; Hedley Ca Emsley Journal: Cochrane Database Syst Rev Date: 2020-07-23
Authors: Rose B Creed; Liliana Menalled; Bradford Casey; Kuldip D Dave; Holden B Janssens; Isaac Veinbergs; Marieke van der Hart; Arash Rassoulpour; Matthew S Goldberg Journal: Neuroscience Date: 2019-04-25 Impact factor: 3.590