Literature DB >> 27104969

Humanized Anti-IL-5 Antibody Therapy.

Marc E Rothenberg1.   

Abstract

Eosinophils are suppressed by a new class of drugs targeting Interleukin-5 (IL-5), an eosinophil growth, activation, and survival factor. Humanized anti-IL-5 antibodies are effective in treating asthma patients with the severe eosinophilic form of the disease and are the first new class of asthma drugs approved in 12 years.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Year:  2016        PMID： 27104969     DOI： 10.1016/j.cell.2016.04.020

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  15 in total

Review 1.  The Regulatory Function of Eosinophils.

Authors:  Ting Wen; Marc E Rothenberg
Journal:  Microbiol Spectr       Date:  2016-10

2.  Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Authors:  Matthew E Poynter
Journal:  Ann Transl Med       Date:  2016-12

3.  A hidden residential cell in the lung.

Authors:  Marc E Rothenberg
Journal:  J Clin Invest       Date:  2016-08-22       Impact factor: 14.808

Review 4.  Mechanisms of gastrointestinal allergic disorders.

Authors:  Nurit P Azouz; Marc E Rothenberg
Journal:  J Clin Invest       Date:  2019-03-11       Impact factor: 14.808

5.  Eosinophil extracellular traps drive asthma progression through neuro-immune signals.

Authors:  Yiwen Lu; Yijiao Huang; Jiang Li; Jingying Huang; Lizhi Zhang; Jingwei Feng; Jiaqian Li; Qidong Xia; Qiyi Zhao; Linjie Huang; Shanping Jiang; Shicheng Su
Journal:  Nat Cell Biol       Date:  2021-10-06       Impact factor: 28.213

6.  Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis.

Authors:  Ting Wen; Bruce J Aronow; Yrina Rochman; Mark Rochman; Kiran Kc; Phil J Dexheimer; Philip Putnam; Vincent Mukkada; Heather Foote; Kira Rehn; Sam Darko; Daniel Douek; Marc E Rothenberg
Journal:  J Clin Invest       Date:  2019-04-08       Impact factor: 14.808

Review 7.  Homeostatic Eosinophils: Characteristics and Functions.

Authors:  Thomas Marichal; Claire Mesnil; Fabrice Bureau
Journal:  Front Med (Lausanne)       Date:  2017-07-11

Review 8.  Resolving Clinical Phenotypes into Endotypes in Allergy: Molecular and Omics Approaches.

Authors:  Tesfaye B Mersha; Yashira Afanador; Elisabet Johansson; Steven P Proper; Jonathan A Bernstein; Marc E Rothenberg; Gurjit K Khurana Hershey
Journal:  Clin Rev Allergy Immunol       Date:  2021-04       Impact factor: 8.667

9.  CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production.

Authors:  Perri Rozenberg; Hadar Reichman; Israel Zab-Bar; Michal Itan; Metsada Pasmanik-Chor; Carine Bouffi; Udi Qimron; Ido Bachelet; Patricia C Fulkerson; Marc E Rothenberg; Ariel Munitz
Journal:  Sci Rep       Date:  2017-07-19       Impact factor: 4.379

10.  Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.

Authors:  Shuying Yi; Jing Zhai; Rui Niu; Guangming Zhu; Meixiang Wang; Jianguo Liu; Hua Huang; Yaping Wang; Xiuli Jing; Li Kang; Wengang Song; Yufang Shi; Hua Tang
Journal:  Nat Commun       Date:  2018-09-24       Impact factor: 14.919
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