Seon-Sook Han1,2, Won Ho Lee1, Yoonki Hong1,2, Woo Jin Kim1,2, JeongHee Yang3, Myoung Nam Lim4, Seung-Joon Lee1,2, Jae-Woo Kwon1,2,5. 1. a Department of Internal Medicine , Kangwon National University College of Medicine , Chuncheon , Korea. 2. b Environmental Health Center , Kangwon National University Hospital , Chuncheon , Korea. 3. c Department of Family Medicine , Kangwon National University School of Medicine , Chuncheon , Korea. 4. d Regional Center for Respiratory Diseases , Kangwon National University Hospital , Chuncheon , Korea. 5. e Department of Allergy and Clinical Immunology , Kangwon National University Hospital , Chuncheon , Korea.
Abstract
OBJECTIVE: Asthma and chronic obstructive pulmonary disease (COPD) have distinct pathophysiological mechanisms but sometimes share similar clinical manifestations. Distinguishing between these diseases is important. This study compared the profiles of serum biomarkers between patients with asthma and those with COPD. METHODS: Serum levels of the chitinase like protein YKL-40, periostin, interleukin (IL)-18, and chemokine (C--C motif) ligand 18 (CCL18) were measured in asthma patients (n = 20), COPD patients (n = 16), and normal controls (n = 20). RESULTS: Serum levels of YKL-40 were higher in COPD patients [median (range), 55 (17-565) versus 208 (74-922) ng/mL, p < 0.0001], but no differences were observed between asthma and COPD patients after adjusting for age and forced expiratory volume in 1 s (FEV1). No differences in serum levels of periostin, IL-18, or CCL18 were observed between the patient groups. Total IgE and airway hypersensitivity were negatively correlated (r = -0.485, p = 0.007). CCL18 levels were related to patients' age in asthmatic patients (r = -0.562, p = 0.010). Serum levels of CCL18 and IL-18 were positively correlated in patients with COPD (r = 0.696, p = 0.003). CONCLUSIONS: No differences in the serum profiles of periostin, IL-18, or CCL18 were observed between patients with asthma and those with COPD. Serum levels of YKL-40 were not different between asthma and COPD patients after adjusting for age and FEV1. There were negative correlation between CCL18 and age in patients with asthma and positive correlation between IL-18 and CCL18 in patients with COPD.
OBJECTIVE:Asthma and chronic obstructive pulmonary disease (COPD) have distinct pathophysiological mechanisms but sometimes share similar clinical manifestations. Distinguishing between these diseases is important. This study compared the profiles of serum biomarkers between patients with asthma and those with COPD. METHODS: Serum levels of the chitinase like protein YKL-40, periostin, interleukin (IL)-18, and chemokine (C--C motif) ligand 18 (CCL18) were measured in asthmapatients (n = 20), COPDpatients (n = 16), and normal controls (n = 20). RESULTS: Serum levels of YKL-40 were higher in COPDpatients [median (range), 55 (17-565) versus 208 (74-922) ng/mL, p < 0.0001], but no differences were observed between asthma and COPDpatients after adjusting for age and forced expiratory volume in 1 s (FEV1). No differences in serum levels of periostin, IL-18, or CCL18 were observed between the patient groups. Total IgE and airway hypersensitivity were negatively correlated (r = -0.485, p = 0.007). CCL18 levels were related to patients' age in asthmatic patients (r = -0.562, p = 0.010). Serum levels of CCL18 and IL-18 were positively correlated in patients with COPD (r = 0.696, p = 0.003). CONCLUSIONS: No differences in the serum profiles of periostin, IL-18, or CCL18 were observed between patients with asthma and those with COPD. Serum levels of YKL-40 were not different between asthma and COPDpatients after adjusting for age and FEV1. There were negative correlation between CCL18 and age in patients with asthma and positive correlation between IL-18 and CCL18 in patients with COPD.
Authors: O A Carpaij; F O W Muntinghe; M B Wagenaar; J W Habing; W Timens; H A M Kerstjens; M C Nawijn; L I Z Kunz; P S Hiemstra; G W Tew; C T J Holweg; C A Brandsma; M van den Berge Journal: Respir Res Date: 2018-06-07
Authors: Sebastian Majewski; Damian Tworek; Karolina Szewczyk; Justyna Kiszałkiewicz; Zofia Kurmanowska; Ewa Brzeziańska-Lasota; Hanna Jerczyńska; Adam Antczak; Wojciech Jerzy Piotrowski; Paweł Górski Journal: Int J Chron Obstruct Pulmon Dis Date: 2019-07-22