| Literature DB >> 27103539 |
Troy A Roepke1, Jennifer A Yang2, Ali Yasrebi2, Kyle J Mamounis2, Elif Oruc2, Aparna Mahakali Zama2, Mehmet Uzumcu2.
Abstract
Developmental exposure to endocrine-disrupting compounds (EDCs) alters reproduction and energy homeostasis, both of which are regulated by the arcuate nucleus (ARC). Little is known about the effects of EDC on ARC gene expression. In Experiment #1, pregnant dams were treated with either two doses of bisphenol A (BPA) or oil from embryonic day (E)18-21. Neonates were injected from postnatal day (PND)0-7. Vaginal opening, body weights, and ARC gene expression were measured. Chrm3 (muscarinic receptor 3) and Adipor1 (adiponectin receptor 1) were decreased by BPA. Bdnf (brain-derived neurotropic factor), Igf1 (insulin-like growth factor 1), Htr2c (5-hydroxytryptamine receptor), and Cck2r (cholescystokinin 2 receptor) were impacted. In Experiment #2, females were exposed to BPA, diethylstilbestrol (DES), di(2-ethylhexyl)phthalate, or methoxychlor (MXC) during E11-PND7. MXC and DES advanced the age of vaginal opening and ARC gene expression was impacted. These data indicate that EDCs alter ARC genes involved in reproduction and energy homeostasis in females.Entities:
Keywords: Arcuate nucleus; Bisphenol a; Diethylstilbestrol; Endocrine-disrupting compounds; Energy homeostasis; Methoxychlor; Phthalates; Puberty
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Year: 2016 PMID： 27103539 PMCID： PMC4905809 DOI： 10.1016/j.reprotox.2016.04.014
Source DB: PubMed Journal: Reprod Toxicol ISSN： 0890-6238 Impact factor: 3.143