Setor K Kunutsor1, Jari A Laukkanen2. 1. School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK. Electronic address: skk31@cantab.net. 2. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.
Abstract
INTRODUCTION: We assessed the association of gamma glutamyltransferase (GGT) with risk of dementia. METHODS: Serum GGT activity was assessed at baseline in the Kuopio Ischemic Heart Disease prospective cohort of 2415 relatively healthy men with good cognitive function. Correction was made for within-person variability in GGT levels. RESULTS: During an average follow-up of 22 years, 219 new cases of dementia were recorded. Serum GGT was log-linearly associated with risk of dementia. The hazard ratio (HR) (95% CIs) for dementia per 1 standard deviation (SD) higher baseline loge GGT values was 1.33 (95% CI = 1.14-1.55) after adjustment for several established and emerging risk factors. The corresponding HR was 1.52 (95% CI = 1.22-1.89) after correction for within-person variability. DISCUSSION: GGT is positively, log-linearly, and independently associated with future risk of dementia in the general male population. Further research is needed to unravel the mechanistic pathways of GGT in the pathogenesis of dementia.
INTRODUCTION: We assessed the association of gamma glutamyltransferase (GGT) with risk of dementia. METHODS: Serum GGT activity was assessed at baseline in the Kuopio Ischemic Heart Disease prospective cohort of 2415 relatively healthy men with good cognitive function. Correction was made for within-person variability in GGT levels. RESULTS: During an average follow-up of 22 years, 219 new cases of dementia were recorded. Serum GGT was log-linearly associated with risk of dementia. The hazard ratio (HR) (95% CIs) for dementia per 1 standard deviation (SD) higher baseline loge GGT values was 1.33 (95% CI = 1.14-1.55) after adjustment for several established and emerging risk factors. The corresponding HR was 1.52 (95% CI = 1.22-1.89) after correction for within-person variability. DISCUSSION: GGT is positively, log-linearly, and independently associated with future risk of dementia in the general male population. Further research is needed to unravel the mechanistic pathways of GGT in the pathogenesis of dementia.
Authors: Sharon J Brown; Gabriel M B Harrington; Charlotte H Hulme; Rachel Morris; Anna Bennett; Wai-Hung Tsang; Aheed Osman; Joy Chowdhury; Naveen Kumar; Karina T Wright Journal: J Neurotrauma Date: 2019-08-06 Impact factor: 5.269
Authors: Andrew S Mendiola; Jae Kyu Ryu; Sophia Bardehle; Anke Meyer-Franke; Kenny Kean-Hooi Ang; Chris Wilson; Kim M Baeten; Kristina Hanspers; Mario Merlini; Sean Thomas; Mark A Petersen; Alexander Williams; Reuben Thomas; Victoria A Rafalski; Rosa Meza-Acevedo; Reshmi Tognatta; Zhaoqi Yan; Samuel J Pfaff; Michael R Machado; Catherine Bedard; Pamela E Rios Coronado; Xiqian Jiang; Jin Wang; Michael A Pleiss; Ari J Green; Scott S Zamvil; Alexander R Pico; Benoit G Bruneau; Michelle R Arkin; Katerina Akassoglou Journal: Nat Immunol Date: 2020-04-13 Impact factor: 25.606