Z-Q Huang1, Z-H Meng2, Z-J Hou3, S-Q Huang4, J-N Chen2, H Yu5, L-J Feng5, Q-J Wang6, P-A Li7, Z-B Wen8. 1. From the Medical Image Center (Z.-Q.H., H.Y., L.-J.F., Z.-B.W.) Medical Image Center (Z.-Q.H., Z.-H.M., J.-N.C.). 2. Medical Image Center (Z.-Q.H., Z.-H.M., J.-N.C.). 3. Department of Radiology (Z.-J.H.), The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China. 4. Department of Radiology (S.-Q.H.), Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China. 5. From the Medical Image Center (Z.-Q.H., H.Y., L.-J.F., Z.-B.W.). 6. Department of Neurosurgery (Q.-J.W.), Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China. 7. Department of Neurosurgery (P.-A.L.), Yuebei People's Hospital, Shantou University Medical College, Shantou, Guangdong Province, China. 8. From the Medical Image Center (Z.-Q.H., H.Y., L.-J.F., Z.-B.W.) zhibowen@163.com.
Abstract
BACKGROUND AND PURPOSE: Previous studies of geometric and morphologic parameters of intracranial aneurysms have been conducted to determine rupture risk, which remains incompletely defined due to patient-specific risk factors, such as sex, hypertension, and age. To this end, we compared characteristics of ruptured and unruptured aneurysms in the same patients with symmetric bilateral intracranial aneurysms. MATERIALS AND METHODS: Between January 2008 and March 2014, 2361 patients with 2674 aneurysms were diagnosed by CT angiography or surgical findings at 4 medical centers. Geometric and morphologic parameters examined for symmetric bilateral intracranial aneurysms comprised aneurysm wall regularity, size, neck width, aspect ratio, size ratio, neck-to-parent artery ratio, and area ratio. Univariate and multivariate statistical analyses were performed to determine independent risk factors for rupture. RESULTS: Sixty-three patients (48 women, 15 men; mean age, 62.5 ± 9.8 years) with symmetric bilateral aneurysms were eligible for the study and were included. The most frequent aneurysm location was the posterior communicating artery. Univariate analysis disclosed that aneurysm size, aspect ratio, size ratio, area ratio, and irregular wall differed between patients with ruptured and unruptured aneurysms. Multivariate analysis indicated that aspect ratio of ≥1.6 (adjusted OR, 9.521; 95% CI, 2.182-41.535), area ratio of ≥1.5 (adjusted OR, 4.089; 95% CI, 1.247-13.406), and irregular shape (adjusted OR, 10.443; 95% CI 3.394-32.135) were significant predictive factors for aneurysm rupture after adjustment for aneurysm size. CONCLUSIONS: An aspect ratio of ≥1.6, area ratio of ≥1.5, and irregular wall are associated with aneurysm rupture independent of aneurysm size and patient characteristics. These characteristics alone can help in distinguishing ruptured bilateral intracranial aneurysms from unruptured ones.
BACKGROUND AND PURPOSE: Previous studies of geometric and morphologic parameters of intracranial aneurysms have been conducted to determine rupture risk, which remains incompletely defined due to patient-specific risk factors, such as sex, hypertension, and age. To this end, we compared characteristics of ruptured and unruptured aneurysms in the same patients with symmetric bilateral intracranial aneurysms. MATERIALS AND METHODS: Between January 2008 and March 2014, 2361 patients with 2674 aneurysms were diagnosed by CT angiography or surgical findings at 4 medical centers. Geometric and morphologic parameters examined for symmetric bilateral intracranial aneurysms comprised aneurysm wall regularity, size, neck width, aspect ratio, size ratio, neck-to-parent artery ratio, and area ratio. Univariate and multivariate statistical analyses were performed to determine independent risk factors for rupture. RESULTS: Sixty-three patients (48 women, 15 men; mean age, 62.5 ± 9.8 years) with symmetric bilateral aneurysms were eligible for the study and were included. The most frequent aneurysm location was the posterior communicating artery. Univariate analysis disclosed that aneurysm size, aspect ratio, size ratio, area ratio, and irregular wall differed between patients with ruptured and unruptured aneurysms. Multivariate analysis indicated that aspect ratio of ≥1.6 (adjusted OR, 9.521; 95% CI, 2.182-41.535), area ratio of ≥1.5 (adjusted OR, 4.089; 95% CI, 1.247-13.406), and irregular shape (adjusted OR, 10.443; 95% CI 3.394-32.135) were significant predictive factors for aneurysm rupture after adjustment for aneurysm size. CONCLUSIONS: An aspect ratio of ≥1.6, area ratio of ≥1.5, and irregular wall are associated with aneurysm rupture independent of aneurysm size and patient characteristics. These characteristics alone can help in distinguishing ruptured bilateral intracranial aneurysms from unruptured ones.
Authors: Daan Backes; Mervyn D I Vergouwen; Birgitta K Velthuis; Irene C van der Schaaf; A Stijntje E Bor; Ale Algra; Gabriel J E Rinkel Journal: Stroke Date: 2014-03-20 Impact factor: 7.914
Authors: Stefan Rohde; Katharina Lahmann; Jürgen Beck; Reinhold Nafe; Bernard Yan; Andreas Raabe; Joachim Berkefeld Journal: Neuroradiology Date: 2005-02-02 Impact factor: 2.804
Authors: Jianping Xiang; Sabareesh K Natarajan; Markus Tremmel; Ding Ma; J Mocco; L Nelson Hopkins; Adnan H Siddiqui; Elad I Levy; Hui Meng Journal: Stroke Date: 2010-11-24 Impact factor: 7.914
Authors: David O Wiebers; J P Whisnant; J Huston; I Meissner; R D Brown; D G Piepgras; G S Forbes; K Thielen; D Nichols; W M O'Fallon; J Peacock; L Jaeger; N F Kassell; G L Kongable-Beckman; J C Torner Journal: Lancet Date: 2003-07-12 Impact factor: 79.321
Authors: R Doddasomayajula; B J Chung; F Mut; C M Jimenez; F Hamzei-Sichani; C M Putman; J R Cebral Journal: AJNR Am J Neuroradiol Date: 2017-10-05 Impact factor: 3.825
Authors: Jun Hyong Ahn; Heung Cheol Kim; Jong Kook Rhim; Jeong Jin Park; Dick Sigmund; Min Chan Park; Jae Hoon Jeong; Jin Pyeong Jeon Journal: J Pers Med Date: 2021-03-24
Authors: Abdulaziz Al-Sharydah; Abdulrahman Al-Abdulwahhab; Sari Al-Suhibani; Afnan Al-Muhanna; Abdullah Abohimed; Abdulmonem AlSharidah; Faisal Alabbas Journal: Int J Gen Med Date: 2021-07-12