| Literature DB >> 27100618 |
Jill Samis1,2, Paul Lee3, Donald Zimmerman1,2, Robert J Arceci4, Meinolf Suttorp5, Nobuko Hijiya2,3.
Abstract
Side effects of tyrosine kinase inhibitor (TKI) treatment vary in children and adults with chronic myelogenous leukemia (CML). As children have a much longer life expectancy than adults, TKI therapy may continue for decades and with long-term consequences that differ from adults. Children may develop endocrinopathies related to "off-target" effects of TKIs, such as delayed growth, changes in bone metabolism, thyroid abnormalities, and effects on puberty and fertility. These endocrinopathies present additional challenges for pediatric patients with CML. This review critically evaluates the literature on long-term endocrine side effects of TKIs in the pediatric CML population and provides suggested recommendations.Entities:
Keywords: CML; TKI; children; endocrine; growth
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Year: 2016 PMID: 27100618 DOI: 10.1002/pbc.26028
Source DB: PubMed Journal: Pediatr Blood Cancer ISSN: 1545-5009 Impact factor: 3.167