| Literature DB >> 27098399 |
WangMi Liu1, Libo Jiang1, Chong Bian1, Yun Liang1, Rong Xing1, Mumingjiang Yishakea1, Jian Dong2.
Abstract
Chemokines are a family of small 8-10 kDa inducible cytokines. Initially characterized as chemotactic factors, they are now considered to affect not just cellular recruitment. CX3CL1 is a unique chemokine that can exist in a soluble form, as a chemotactic cytokine, or in a membrane-attached form that acts as a binding molecule. Recently, the effects of CX3CL1 on diseases, such as inflammation and cancer, have been supported and confirmed by numerous publications. However, due to its dual effects, CX3CL1 exerts numerous effects on pathophysiological conditions that have both negative and positive consequences on pathogenesis and outcome. This review article summarizes the important scientific and clinical data that now point to a critical role for CX3CL1 in diseases.Entities:
Keywords: CX3CL1; Chemokine; Disease
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Year: 2016 PMID： 27098399 DOI： 10.1007/s00005-016-0395-9
Source DB: PubMed Journal: Arch Immunol Ther Exp (Warsz) ISSN： 0004-069X Impact factor: 4.291