Zheng Feng1, Hao Wen1, Rui Bi2, Wentao Yang2, Xiaohua Wu3. 1. Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. 2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. 3. Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. Electronic address: docwuxh@hotmail.com.
Abstract
OBJECTIVE: The aim of our study was to investigate the prognostic influence of time to chemotherapy (TTC) in patients with high grade serous ovarian cancer (HGSC). METHODS: We retrospectively investigated 625 consecutive patients with HGSC who underwent primary staging or debulking surgery followed by platinum-based intravenous chemotherapy between April 2005 and June 2013 in our center. TTC was defined as the time interval between primary surgery and initiation of chemotherapy. RESULTS: The median (range) TTC was 15 (4-62) days. TTC was longer for patients who underwent bowel resection (p<0.001). There were no differences in PFS and OS between patients initiating chemotherapy before and after 15days (p=0.604 and 0.826, respectively) or among 4 groups categorized by quartile values (<10days, 10-14days, 15-20days, or ≥21days after surgery) (p=0.471 and 0.516, respectively). When stratified by with and without residual disease, there were still no differences in PFS (p=0.592 and 0.755, respectively) and OS (p=0.962 and 0.640, respectively) between patients initiating chemotherapy before and after 15days. In multivariate analyses, TTC was also not associated with PFS and OS categorized by median (p=0.570 and 0.701, respectively), quartile values (p=0.432, 0.194, 0.737 and 0.799, 0.290, 0.743, respectively) or integrated as a continuous variable (p=0.550 and 0.430, respectively). CONCLUSION: The time interval between surgery and chemotherapy seemed to have no prognostic impact on patients with HGSC within 6weeks.
OBJECTIVE: The aim of our study was to investigate the prognostic influence of time to chemotherapy (TTC) in patients with high grade serous ovarian cancer (HGSC). METHODS: We retrospectively investigated 625 consecutive patients with HGSC who underwent primary staging or debulking surgery followed by platinum-based intravenous chemotherapy between April 2005 and June 2013 in our center. TTC was defined as the time interval between primary surgery and initiation of chemotherapy. RESULTS: The median (range) TTC was 15 (4-62) days. TTC was longer for patients who underwent bowel resection (p<0.001). There were no differences in PFS and OS between patients initiating chemotherapy before and after 15days (p=0.604 and 0.826, respectively) or among 4 groups categorized by quartile values (<10days, 10-14days, 15-20days, or ≥21days after surgery) (p=0.471 and 0.516, respectively). When stratified by with and without residual disease, there were still no differences in PFS (p=0.592 and 0.755, respectively) and OS (p=0.962 and 0.640, respectively) between patients initiating chemotherapy before and after 15days. In multivariate analyses, TTC was also not associated with PFS and OS categorized by median (p=0.570 and 0.701, respectively), quartile values (p=0.432, 0.194, 0.737 and 0.799, 0.290, 0.743, respectively) or integrated as a continuous variable (p=0.550 and 0.430, respectively). CONCLUSION: The time interval between surgery and chemotherapy seemed to have no prognostic impact on patients with HGSC within 6weeks.
Authors: Andrew Bryant; Shaun Hiu; Patience T Kunonga; Ketankumar Gajjar; Dawn Craig; Luke Vale; Brett A Winter-Roach; Ahmed Elattar; Raj Naik Journal: Cochrane Database Syst Rev Date: 2022-09-26
Authors: Orestis Tsonis; Fani Gkrozou; Konstantinos Vlachos; Minas Paschopoulos; Michail C Mitsis; Nikolaos Zakynthinakis-Kyriakou; Stergios Boussios; George Pappas-Gogos Journal: Ann Transl Med Date: 2020-12
Authors: Soo Young Jeong; Chel Hun Choi; Tae Joong Kim; Jeong Won Lee; Byoung-Gie Kim; Duk Soo Bae; Yoo-Young Lee Journal: J Ovarian Res Date: 2019-12-31 Impact factor: 4.234