Literature DB >> 27097846

Synthesis of 2-Indolyltetrahydroquinolines by Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylanilines with Indoles.

Guangzhe Li1, Hiroyuki Nakamura2.   

Abstract

An intramolecular hydroarylation-redox cross-dehydrogenative coupling (CDC) of propargylic anilines with indoles proceeded in the presence of zinc(II) catalysts to give 2-indolyltetrahydroquinolines in good to high yields. Three C-H bonds (two sp(2) and one sp(3) ) are activated in one shot and these hydrogen atoms are trapped by a propargylic triple bond in the molecule.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  C−H activation; cross-dehydrogenative coupling; intramolecular hydroarylation; tetrahydroquinoline; zinc catalysts

Year:  2016        PMID： 27097846     DOI： 10.1002/anie.201602416

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  2 in total

1.  3-Dialkylamino-1,2,4-triazoles via ZnII-Catalyzed Acyl Hydrazide-Dialkylcyanamide Coupling.

Authors:  Sevilya N Yunusova; Dmitrii S Bolotin; Vitalii V Suslonov; Mikhail A Vovk; Peter M Tolstoy; Vadim Yu Kukushkin
Journal:  ACS Omega       Date:  2018-07-03

2.  Oxidative Asymmetric Formal Aza-Diels⁻Alder Reactions of Tetrahydro-β-carboline with Enones in the Synthesis of Indoloquinolizidine-2-ones.

Authors:  Xiang Wu; Shi-Bao Zhao; Lang-Lang Zheng; You-Gui Li
Journal:  Molecules       Date:  2018-09-01       Impact factor: 4.411
  2 in total

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