Ihsan Cetin1, Ihsan Tezdig2, Mahmut Cem Tarakcioglu3, Muhammed Tayyib Kadak4, Omer Faruk Demirel5, Omer Faruk Ozer6. 1. a Department of Nutrition and Dietetics , School of Health, Batman University , Batman , Turkey ; 2. b Department of Chemistry , Institute of Science, Batman University , Batman , Turkey ; 3. c Clinic of Child and Adolescent Psychiatry , Bakirköy Dr Sadi Konuk Training and Educatin Hospital, Istanbul University , İstanbul , Turkey ; 4. d Department of Child and Adolescent Psychiatry , Cerrahpaşa School of Medicine, Istanbul University , İstanbul , Turkey ; 5. e Department of Psychiatry , Cerrahpaşa School of Medicine, Istanbul University , İstanbul , Turkey ; 6. f Department of Biochemistry , BezmiAlem Vakif University , İstanbul , Turkey.
Abstract
CONTEXT: Improved biomarkers would facilitate the diagnosis and treatment of autism spectrum disorders (ASD). OBJECTIVE: Our objective was to examine the levels of Nogo-A and glial fibrillary acidic protein (GFAP) in children with ASD. MATERIALS AND METHODS: Serum concentrations of GFAP and Nogo-A were determined by enzyme-linked immunosorbent assay. RESULTS: In this preliminary study, we found that serum Nogo-A was not found significantly different between groups, while serum levels of GFAP were significantly lower in ASD than controls. DISCUSSION AND CONCLUSIONS: It will be of great interest to determine other potential causes of elevated serum levels of GFAP, and whether this elevation has any phenotypic effect.
CONTEXT: Improved biomarkers would facilitate the diagnosis and treatment of autism spectrum disorders (ASD). OBJECTIVE: Our objective was to examine the levels of Nogo-A and glial fibrillary acidic protein (GFAP) in children with ASD. MATERIALS AND METHODS: Serum concentrations of GFAP and Nogo-A were determined by enzyme-linked immunosorbent assay. RESULTS: In this preliminary study, we found that serum Nogo-A was not found significantly different between groups, while serum levels of GFAP were significantly lower in ASD than controls. DISCUSSION AND CONCLUSIONS: It will be of great interest to determine other potential causes of elevated serum levels of GFAP, and whether this elevation has any phenotypic effect.