Literature DB >> 27097564

Antigen arrays for profiling autoantibody repertoires.

Burcu Ayoglu1,2, Jochen M Schwenk1, Peter Nilsson1.   

Abstract

Autoantibodies are a key component for the diagnosis, prognosis and monitoring of various diseases. In order to discover novel autoantibody targets, highly multiplexed assays based on antigen arrays hold a great potential and provide possibilities to analyze hundreds of body fluid samples for their reactivity pattern against thousands of antigens in parallel. Here, we provide an overview of the available technologies for producing antigen arrays, highlight some of the technical and methodological considerations and discuss their applications as discovery tools. Together with recent studies utilizing antigen arrays, we give an overview on how the different types of antigen arrays have and will continue to deliver novel insights into autoimmune diseases among several others.

Entities:  

Keywords:  affinity proteomics; antigen microarrays; autoantibodies; autoantibody profiling; autoimmunity; protein biomarker discovery

Mesh：

Substances：

Year:  2016        PMID： 27097564     DOI： 10.4155/bio.16.31

Source DB:  PubMed          Journal:  Bioanalysis        ISSN： 1757-6180            Impact factor:   2.681


  11 in total

1.  Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational Data.

Authors:  Vera Ignjatovic; Philipp E Geyer; Krishnan K Palaniappan; Jessica E Chaaban; Gilbert S Omenn; Mark S Baker; Eric W Deutsch; Jochen M Schwenk
Journal:  J Proteome Res       Date:  2019-10-11       Impact factor: 4.466

2.  Current Techniques to Accurately Measure Anti-retinal Autoantibodies.

Authors:  Grazyna Adamus
Journal:  Expert Rev Ophthalmol       Date:  2020-03-12

3.  Serum Autoantibody Profiling of Patients with Paraneoplastic and Non-Paraneoplastic Autoimmune Retinopathy.

Authors:  Josianne C Ten Berge; Joost van Rosmalen; Jacolien Vermeer; Cecilia Hellström; Cecilia Lindskog; Peter Nilsson; Ulrika Qundos; Aniki Rothova; Marco W J Schreurs
Journal:  PLoS One       Date:  2016-12-08       Impact factor: 3.240

4.  Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling.

Authors:  Helle Sadam; Arno Pihlak; Anri Kivil; Susan Pihelgas; Mariliis Jaago; Priit Adler; Jaak Vilo; Olli Vapalahti; Toomas Neuman; Dan Lindholm; Markku Partinen; Antti Vaheri; Kaia Palm
Journal:  EBioMedicine       Date:  2018-02-02       Impact factor: 8.143

5.  Generation of anti-idiotypic antibodies to detect anti-spacer antibody idiotopes in acute thrombotic thrombocytopenic purpura patients.

Authors:  An-Sofie Schelpe; Elien Roose; Bérangère S Joly; Inge Pareyn; Ilaria Mancini; Marina Biganzoli; Hans Deckmyn; Jan Voorberg; Rob Fijnheer; Flora Peyvandi; Simon F De Meyer; Paul Coppo; Agnès Veyradier; Karen Vanhoorelbeke
Journal:  Haematologica       Date:  2018-12-06       Impact factor: 9.941

6.  The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients.

Authors:  Maria Mikus; Catharina Johansson; Nathalie Acevedo; Peter Nilsson; Annika Scheynius
Journal:  Clin Transl Allergy       Date:  2019-01-31       Impact factor: 5.871

7.  Unique Cholangiocyte-Targeted IgM Autoantibodies Correlate With Poor Outcome in Biliary Atresia.

Authors:  Yuhuan Luo; Dania Brigham; Joseph Bednarek; Richard Torres; Dong Wang; Sara Ahmad; Cara L Mack
Journal:  Hepatology       Date:  2021-04-27       Impact factor: 17.425

8.  Complement C4A Regulates Autoreactive B Cells in Murine Lupus.

Authors:  Léa Simoni; Jessy Presumey; Cees E van der Poel; Carlos Castrillon; Sarah E Chang; Paul J Utz; Michael C Carroll
Journal:  Cell Rep       Date:  2020-11-03       Impact factor: 9.423

9.  Presence of Antibodies Binding to Negative Elongation Factor E in Sarcoidosis.

Authors:  Niklas Baerlecken; Nils Pursche; Torsten Witte; Katja Kniesch; Marius Höpfner; Diana Ernst; Frank Moosig; Benjamin Seeliger; Antje Prasse
Journal:  J Clin Med       Date:  2020-03-06       Impact factor: 4.241

10.  Longitudinal serum autoantibody repertoire profiling identifies surgery-associated biomarkers in lung adenocarcinoma.

Authors:  Yang Li; Cheng-Qiang Li; Shu-Juan Guo; Wei Guo; He-Wei Jiang; He-Cheng Li; Sheng-Ce Tao
Journal:  EBioMedicine       Date:  2020-02-26       Impact factor: 8.143
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