Mikhail V Zykov1, Olga L Barbarash2, Vasiliy V Kashtalap2, Anton G Kutikhin3, Leonid S Barbarash1. 1. Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation. 2. Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation; Kemerovo State Medical Academy, Voroshilova Street 22A, Kemerovo 650029, Russian Federation. 3. Research Institute for Complex Issues of Cardiovascular Diseases, Sosnovy Boulevard 6, Kemerovo 650002, Russian Federation. Electronic address: antonkutikhin@gmail.com.
Abstract
OBJECTIVES: The study aimed to evaluate whether serum inflammatory markers have prognostic value in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: The role of cytokine-driven inflammation in the development of postdischarge complications after STEMI is obscured. METHODS: We recruited 214 patients who were admitted within 24 h of STEMI onset to our Institute. IL-1α, -6, -8, -10, -12, TNF-α, and CRP serum levels were measured on the 10-14th day after STEMI onset. RESULTS: Serum levels of IL-12, TNF-α, and CRP were significantly higher in patients with 3 affected coronary arteries compared to those with 1 affected coronary artery. However, only Killip class II-IV at admission and IL-12 serum level ≥90.0 pg/mL were defined as statistically significant predictors of adverse outcome after 1 year of follow-up. CONCLUSION: IL-12 serum level may be suggested as a candidate prognostic marker if measured 10-14 days after STEMI onset.
OBJECTIVES: The study aimed to evaluate whether serum inflammatory markers have prognostic value in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: The role of cytokine-driven inflammation in the development of postdischarge complications after STEMI is obscured. METHODS: We recruited 214 patients who were admitted within 24 h of STEMI onset to our Institute. IL-1α, -6, -8, -10, -12, TNF-α, and CRP serum levels were measured on the 10-14th day after STEMI onset. RESULTS: Serum levels of IL-12, TNF-α, and CRP were significantly higher in patients with 3 affected coronary arteries compared to those with 1 affected coronary artery. However, only Killip class II-IV at admission and IL-12 serum level ≥90.0 pg/mL were defined as statistically significant predictors of adverse outcome after 1 year of follow-up. CONCLUSION: IL-12 serum level may be suggested as a candidate prognostic marker if measured 10-14 days after STEMI onset.
Authors: Irene Maeve Rea; David S Gibson; Victoria McGilligan; Susan E McNerlan; H Denis Alexander; Owen A Ross Journal: Front Immunol Date: 2018-04-09 Impact factor: 7.561
Authors: Anna Lebedeva; Wendy Fitzgerald; Ivan Molodtsov; Alexander Shpektor; Elena Vasilieva; Leonid Margolis Journal: Sci Rep Date: 2020-12-03 Impact factor: 4.379