Ashok Kumar Saxena1, Kavitha Lakshman2, Tusha Sharma3, Neha Gupta1, Basu Dev Banerjee3, Archana Singal4. 1. Pain Clinic, Division under Department of Anaesthesiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India. 2. Department of Anaesthesiology & Pain Relief, Kidwai Memorial Institute of Oncology, Bangalore, India. 3. Department of Biochemistry, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India. 4. Department of Dermatology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.
Abstract
AIM: To study the modulation of serum BDNF levels following integrated multimodal intervention in postherpetic neuralgia (PHN). MATERIALS & METHODS: A randomized, double-blind controlled study was undertaken among patients of thoracic PHN where 30 patients receivedpregabalin with pulsed radiofrequency and 30 controls received pregabalin with sham treatment. RESULTS:Pain intensity (visual analog scale) was reduced earlier in intervention group (15.3 ± 5.7 at the fourth week) compared with control group (16.3 ± 6.6 at the eighth week). Serum BDNF level increased with time in both the groups with overall increase more pronounced in intervention group. CONCLUSION: Integrated multimodal therapy using minimally invasive pulsed radiofrequency and pregabalin in PHN was effective in early pain reduction with elevated serum BDNF levels.
RCT Entities:
AIM: To study the modulation of serum BDNF levels following integrated multimodal intervention in postherpetic neuralgia (PHN). MATERIALS & METHODS: A randomized, double-blind controlled study was undertaken among patients of thoracic PHN where 30 patients received pregabalin with pulsed radiofrequency and 30 controls received pregabalin with sham treatment. RESULTS:Pain intensity (visual analog scale) was reduced earlier in intervention group (15.3 ± 5.7 at the fourth week) compared with control group (16.3 ± 6.6 at the eighth week). Serum BDNF level increased with time in both the groups with overall increase more pronounced in intervention group. CONCLUSION: Integrated multimodal therapy using minimally invasive pulsed radiofrequency and pregabalin in PHN was effective in early pain reduction with elevated serum BDNF levels.
Entities:
Keywords:
BDNF; postherpetic neuralgia; pregabalin; pulsed radiofrequency; quality of life
Authors: Shimaa Mohammad Yousof; Doaa Attia ElSayed; Amani A El-Baz; Hanaa S Sallam; Faten Abbas Journal: Stem Cells Int Date: 2021-02-15 Impact factor: 5.443