Ramya Rajamanickam1, Lakshmi Shanmugavelu2, Sundari Subramanian3, Hemchand Krishna Prasad4, Nedunchelian Krishnamoorthy5. 1. Department of Pediatrics, St Anthony Hospital, Chennai, Tamil Nadu, India. 2. Department of Pediatrics, Stanley Medical College, Chennai, Tamil Nadu, India. 3. Department of Pediatrics, Institute of Child Health and Hospital for Children, Chennai, Tamil Nadu, India. 4. Department of Pediatric Endocrinology, Dr. Mehta's Children's Hospital, 2 Mc Nichols Road, Chetpet, Chennai 31, Tamil Nadu, India. pediatricendocrinology.mehta@gmail.com. 5. Dr. Mehta's Children's Hospital, Chennai, Tamil Nadu, India.
Abstract
OBJECTIVE: To describe the clinical and investigatory profile of children with Hashimoto's thyroiditis (HT) presenting to the thyroid clinic of a referral children's hospital and study the course of children diagnosed as HT over a period of 6 mo. METHODS: Children aged 5-12 y with HT were recruited, their clinical and biochemical details were assessed and were started on standard therapy and followed up for a period of 6 mo. RESULTS: Ninety-seven children (89 goitrous and 8 atrophic form) with mean age: 9.90 ± 1.76 y; M:F 1:5.4 were recruited; 55.7 % were asymptomatic;14.2 % had familial clustering. The mean height, weight and BMI for age Z-scores were -1.0 ± 1.0, -0.8 ± 0.9 and -0.5 ± 1.1 respectively. 16.4 % had short stature; 4.1 % had obesity; 72.2 % had grade 2 goitre. 73.4 %, 13.2 %, 10.3 % and 3.1 % had overt hypothyroidism, sub-clinical hypothyroidism, euthyroidism and hyperthyroidism, respectively. On follow up, 38.5 % of euthyroid and 80 % of sub-clinical hypothyroid children developed overt hypothyroidism. Thyrotoxic symptoms resolved in all three Hashitoxic children by 6 mo. CONCLUSIONS: A female preponderance, less familial clustering, higher paucity of clinical manifestations and quick progression to hypothyroidism (in those without) were noted in the present series.
OBJECTIVE: To describe the clinical and investigatory profile of children with Hashimoto's thyroiditis (HT) presenting to the thyroid clinic of a referral children's hospital and study the course of children diagnosed as HT over a period of 6 mo. METHODS:Children aged 5-12 y with HT were recruited, their clinical and biochemical details were assessed and were started on standard therapy and followed up for a period of 6 mo. RESULTS: Ninety-seven children (89 goitrous and 8 atrophic form) with mean age: 9.90 ± 1.76 y; M:F 1:5.4 were recruited; 55.7 % were asymptomatic;14.2 % had familial clustering. The mean height, weight and BMI for age Z-scores were -1.0 ± 1.0, -0.8 ± 0.9 and -0.5 ± 1.1 respectively. 16.4 % had short stature; 4.1 % had obesity; 72.2 % had grade 2 goitre. 73.4 %, 13.2 %, 10.3 % and 3.1 % had overt hypothyroidism, sub-clinical hypothyroidism, euthyroidism and hyperthyroidism, respectively. On follow up, 38.5 % of euthyroid and 80 % of sub-clinical hypothyroidchildren developed overt hypothyroidism. Thyrotoxic symptoms resolved in all three Hashitoxic children by 6 mo. CONCLUSIONS: A female preponderance, less familial clustering, higher paucity of clinical manifestations and quick progression to hypothyroidism (in those without) were noted in the present series.
Authors: R K Marwaha; R Sankar; M Magdum; V S Nijahvan; C M Khanna; C B Jaggi; V Ambardar; N S Maharda; R P Walia; S K Jain Journal: Indian Pediatr Date: 1998-10 Impact factor: 1.411
Authors: R K Marwaha; N Tandon; Ratnesh Kanwar; M Ashraf Ganie; V Bhattacharya; D H K Reddy; Sripathy Gopalakrishnan; R Aggarwal; Khushi Grewal; S K Ganguly; Kalaivani Mani Journal: Indian Pediatr Date: 2008-04 Impact factor: 1.411