| Literature DB >> 27094618 |
Kyungmi Oh1, Soo-Jin Cho2, Yun Kyung Chung3, Jae-Moon Kim4, Min Kyung Chu5.
Abstract
Entities:
Year: 2016 PMID: 27094618 PMCID: PMC4837543 DOI: 10.1186/s12883-016-0571-x
Source DB: PubMed Journal: BMC Neurol ISSN: 1471-2377 Impact factor: 2.474
Sociodemographic distribution of all survey participants, the total Korean population, and of cases identified as migraine, anxiety and depression
| Survey participants | Total population |
| Migraine | Anxiety | Depression | |
|---|---|---|---|---|---|---|
| Men | 1345 (49.3) | 17,584,365 (50.6) | 0.854a | 36, 2.7 (1.8–3.5) | 109, 8.1 (6.6–9.6) | 43, 3.2 (2.3–4.2) |
| Women | 1350 (50.7) | 17,198,350 (49.4) | 107, 7.9 (6.5–9.4) | 159, 11.8 (10.1–13.5) | 73, 5.4 (4.2–6.6) | |
| Age | ||||||
| 19–29 | 542 (20.5) | 7,717,947 (22.2) | 0.917a | 25, 4.5 (2.7–6.2) | 53, 9.6 (7.2–12.1) | 23, 4.1 (2.5–5.8) |
| 30–39 | 604 (21.9) | 8,349,487 (24.0) | 42, 7.0 (4.9–9.1) | 51, 8.7 (6.4–11.0) | 32, 5.4 (4.6–7.3) | |
| 40–49 | 611 (23.1) | 8,613,110 (24.8) | 39, 6.5 (4.5–8.4) | 67, 11.0 (8.5–13.5) | 24, 4.0 (2.5–5.5) | |
| 50–59 | 529 (18.9) | 6,167,505 (17.7) | 22, 4.1 (2.4–5.9) | 53, 9.9 (7.3–12.5) | 22, 4.2 (2.5–6.0) | |
| 60–69 | 409 (15.6) | 3,934,666 (11.3) | 15, 3.9 (2.0–5.7) | 14, 10.8 (7.8–13.8) | 15, 3.7 (2.0–5.5) | |
| Size of residential area | ||||||
| Large city | 1248 (46.3) | 16,776,771 (48.2) | 0.921a | 76, 6.1 (4.8–7.5) | 130, 10.4 (8.7–12.1) | 57, 4.6 (3.4–5.7) |
| Medium–to–small city | 1186 (44.0) | 15,164,345 (43.6) | 48, 4.0 (2.9–5.2) | 112, 9.5 (7.8–11.2) | 47, 4.0 (2.9–5.1) | |
| Rural area | 261 (9.7) | 2,841,599 (8.2) | 19, 7.4 (4.2–10.6) | 26, 10.0 (6.3–13.6) | 12, 4.7 (2.1–7.3) | |
| Education level | ||||||
| Middle school or less | 393 (14.9) | 6,608,716 (19.0) | 0.752a | 22, 5.5 (4.2–7.7) | 55, 13.9 (10.5–17.4) | 20, 5.2 (3.0–7.4) |
| High school | 1208 (44.5) | 15,234,829 (43.8) | 60, 5.0 (3.8–6.3) | 111, 9.2 (7.5–10.8) | 49, 4.1 (3.0–5.2) | |
| College or more | 1068 (39.6) | 12,939,170 (37.2) | 60, 5.6 (4.3–7.0) | 100, 9.5 (7.7–11.2) | 47, 4.4 (3.2–5.7) | |
| Not responded | 26 (9.6) | 1, 3.8 (0.0–11.8) | 2, 8.0 (0.0–18.0) | 0, 0.0 (0.0–0.0) | ||
| Total | 2695 (100.0) | 34,782,715 (100.0) | 143, 5.3 (4.5–6.2) | 268, 10.0 (8.8–11.1) | 116, 4.3 (3.6–5.1) | |
aCompared gender, age group, size of residential area, and educational level distributions between the sample of the present study and total population of Korea
Fig. 1Flow chart depicting the participation of subjects in the Korean Headache-Sleep Study
Fig. 2Venn diagram for distribution of subjects with anxiety, depression and migraine
Demographics, headache characteristics and associated symptoms of migraineurs according to anxiety and depression
| Migraine subjects without anxiety or depression, | Migraine subjects with anxiety alone, | Migraine subjects with depression alone, | Migraine with anxiety and depression, |
| |
|---|---|---|---|---|---|
| Demographics | |||||
| Mean age ± SD (years) | 40.4 ± 11.4 | 47.2 ± 14.5 | 42.1 ± 15.7 | 44.5 ± 18.4 | 0.131 |
| Women, | 71 (75.5) | 21 (77.8) | 7 (77.8) | 13 (76.5) | 0.995 |
| Headache characteristics | |||||
| Unilateral pain, | 57 (60.6) | 15 (53.6) | 4 (44.4) | 7 (41.2) | 0.409 |
| Pulsating quality, | 72 (76.6) | 21 (77.8) | 7 (77.8) | 12 (70.6) | 0.950 |
| Moderate-to-severe severity, | 72 (75.8) | 22 (81.5) | 8 (88.9) | 17 (100.0) | 0.119 |
| Aggravation by movement, | 60 (63.8) | 21 (77.8) | 5 (55.6) | 15 (88.2) | 0.121 |
| Associated symptoms | |||||
| Nausea, | 84 (88.4) | 23 (82.1) | 9 (100.0) | 15 (88.2) | 0.544 |
| Vomiting, | 33 (34.7) | 15 (53.6) | 3 (33.3) | 8 (47.1) | 0.288 |
| Photophobia, | 55 (57.9) | 19 (70.4) | 1 (11.1) | 11 (64.7) | 0.017 |
| Phonophobia, | 63 (67.0) | 21 (77.8) | 6 (66.7) | 13 (76.5) | 0.668 |
| Osmophobia, | 42 (44.7) | 13 (48.1) | 4 (44.4) | 9 (46.3) | 0.930 |
Frequency, severity and impact of headache according to migraineurs’ anxiety and depression status
| Migraine subjects without anxiety or depression, | Migraine subjects with anxiety alone, | Migraine subjects with depression alone, | Migraine subjects with anxiety and depression, |
| Post hoc analysis with Bonferroni’s correction | |
|---|---|---|---|---|---|---|
| Median (25 %–75 %) | Median (25 %–75 %) | Median (25 %–75 %) | Median (25 %–75 %) | |||
| Frequency per month | 1.0 (0.3–3.0) | 2.0 (1.0–5.0) | 1.0 (0.3–4.0) | 8.0 (2.5–21.0) | <0.001 | 1 vs. 2 = 0.596 |
| 1 vs.3 = 1.000 | ||||||
| 1 vs. 4 < 0.001 | ||||||
| 2 vs.3 = 1.000 | ||||||
| 2 vs. 4 = 0.003 | ||||||
| 3 vs. 4 = 0.001 | ||||||
| VAS score for pain intensity | 6.0 (5.0–7.0) | 7.0 (6.0–8.0) | 7.0 (6.0–8.0) | 7.0 (5.0–9.0) | <0.001 | 1 vs. 2 = 0.011 |
| 1 vs.3 = 0.824 | ||||||
| 1 vs. 4 = 0.018 | ||||||
| 2 vs.3 = 1.000 | ||||||
| 2 vs. 4 = 1.000 | ||||||
| 3 vs. 4 = 1.000 | ||||||
| HIT–6 score | 50.0 (46.0–58.0) | 57.0 (49.0–60.8) | 62.0 (52.0–70.5) | 64.0 (61.0–67.0) | <0.001 | 1 vs. 2 = 0.074 |
| 1 vs.3 = 0.004 | ||||||
| 1 vs. 4 < 0.001 | ||||||
| 2 vs.3 = 0.545 | ||||||
| 2 vs. 4 = 0.005 | ||||||
| 3 vs. 4 = 1.000 |
HIT–6: Headache Impact Test–6; VAS: Visual Analogue Scale
*Kruskal–Wallis one–way analysis of variance test among the four groups: migraine subjects without anxiety or depression, migraine subjects with anxiety alone, migraine subjects with depression alone and migraine subjects with anxiety and depression
1: migraine subjects without anxiety or depression; 2: migraine subjects with anxiety alone; 3: migraine subjects with depression alone; 4: migraine with anxiety and depression