Colleen M Makey1, Michael D McClean2, Lewis E Braverman3, Elizabeth N Pearce3, Andreas Sjödin4, Janice Weinberg5, Thomas F Webster2. 1. Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA. Electronic address: cmakey@bu.edu. 2. Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA. 3. Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 72 E. Concord Street, Boston, MA 02118, USA. 4. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA. 5. Department of Biostatistics, Boston University School of Public Health, 1010 Massachusetts Ave, Boston, MA 02118, USA.
Abstract
BACKGROUND: Polybrominated diphenyl ethers (PBDEs) are flame retardant chemicals that are persistent organic pollutants. Animal experiments and some human studies indicate that PBDEs may adversely affect male reproductive function. OBJECTIVES: To assess the association between PBDE exposure and reproductive hormones (RHs) in a North American male adult cohort. METHODS: From 2010-11, we collected three serum samples from 27 healthy adult men. We assessed associations between PBDEs and RHs using mixed effect regression models. RESULTS: PBDEs were inversely associated with inhibin-B. In older men, increased concentrations of BDE-47 and BDE-100 were significantly associated with a decrease in inhibin-B, and an increase in follicular stimulating hormone (FSH). CONCLUSIONS: These findings suggest PBDE exposure may affect RHs in older men. We did not measure other parameters of male reproductive function and therefore these results are preliminary.
BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are flame retardant chemicals that are persistent organic pollutants. Animal experiments and some human studies indicate that PBDEs may adversely affect male reproductive function. OBJECTIVES: To assess the association between PBDE exposure and reproductive hormones (RHs) in a North American male adult cohort. METHODS: From 2010-11, we collected three serum samples from 27 healthy adult men. We assessed associations between PBDEs and RHs using mixed effect regression models. RESULTS:PBDEs were inversely associated with inhibin-B. In older men, increased concentrations of BDE-47 and BDE-100 were significantly associated with a decrease in inhibin-B, and an increase in follicular stimulating hormone (FSH). CONCLUSIONS: These findings suggest PBDE exposure may affect RHs in older men. We did not measure other parameters of male reproductive function and therefore these results are preliminary.
Authors: D L Phillips; J L Pirkle; V W Burse; J T Bernert; L O Henderson; L L Needham Journal: Arch Environ Contam Toxicol Date: 1989 Jul-Aug Impact factor: 2.804
Authors: K Akutsu; S Takatori; S Nozawa; M Yoshiike; H Nakazawa; K Hayakawa; T Makino; T Iwamoto Journal: Bull Environ Contam Toxicol Date: 2008-03-05 Impact factor: 2.151
Authors: Arnold Schecter; Darrah Haffner; Justin Colacino; Keyur Patel; Olaf Päpke; Matthias Opel; Linda Birnbaum Journal: Environ Health Perspect Date: 2009-10-28 Impact factor: 9.031
Authors: Mary E Turyk; Victoria W Persky; Pamela Imm; Lynda Knobeloch; Robert Chatterton; Henry A Anderson Journal: Environ Health Perspect Date: 2008-07-24 Impact factor: 9.031
Authors: Vishal Singh; Javier Cortes-Ramirez; Leisa-Maree Toms; Thilakshika Sooriyagoda; Shamshad Karatela Journal: Int J Environ Res Public Health Date: 2022-06-25 Impact factor: 4.614
Authors: Keith R Shockley; Michelle C Cora; David E Malarkey; Daven Jackson-Humbles; Molly Vallant; Brad J Collins; Esra Mutlu; Veronica G Robinson; Surayma Waidyanatha; Amy Zmarowski; Nicholas Machesky; Jamie Richey; Sam Harbo; Emily Cheng; Kristin Patton; Barney Sparrow; June K Dunnick Journal: Toxicol Lett Date: 2020-07-15 Impact factor: 4.372
Authors: Mary E Ingle; Lidia Mínguez-Alarcón; Courtney C Carignan; Heather M Stapleton; Paige L Williams; Jennifer B Ford; Molly B Moravek; Marie S O'Neill; Lu Wang; Russ Hauser; John D Meeker Journal: Environ Res Date: 2020-09-22 Impact factor: 6.498
Authors: Linda G Kahn; Kim G Harley; Eva L Siegel; Yeyi Zhu; Pam Factor-Litvak; Christina A Porucznik; Michele Klein-Fedyshin; Alison E Hipwell Journal: Hum Reprod Update Date: 2021-02-19 Impact factor: 15.610
Authors: J K Dunnick; A R Pandiri; B A Merrick; G E Kissling; H Cunny; E Mutlu; S Waidyanatha; R Sills; H L Hong; T V Ton; T Maynor; L Recio; S L Phillips; M J Devito; A Brix Journal: Toxicol Rep Date: 2018-05-25