Zhobin Moghadamyeghaneh1, Mark H Hanna1, Grace Hwang1, Steven Mills1, Alessio Pigazzi1, Michael J Stamos1, Joseph C Carmichael2. 1. Department of Surgery, University of California, Irvine, School of Medicine, Irvine, 333 City Blvd West, Suite 850, Orange, CA, 92868, USA. 2. Department of Surgery, University of California, Irvine, School of Medicine, Irvine, 333 City Blvd West, Suite 850, Orange, CA, 92868, USA. Electronic address: jcarmich@uci.edu.
Abstract
BACKGROUND: Patients with advanced colorectal cancer have a high incidence of postoperative complications. We sought to identify outcomes of patients who underwent resection for colon cancer by cancer stage. METHODS: The National Surgical Quality Improvement Program database was used to evaluate all patients who underwent colon resection with a diagnosis of colon cancer from 2012 to 2014. Multivariate logistic regression analysis was performed to investigate patient outcomes by cancer stage. RESULTS: A total of 7,786 colon cancer patients who underwent colon resection were identified. Of these, 10.8% had metastasis at the time of operation. Patients with metastatic disease had significantly increased risks of perioperative morbidity (adjusted odds ratio [AOR]: 1.44, P = .01) and mortality (AOR: 3.72, P = .01). Patients with metastatic disease were significantly younger (AOR: .99, P < .01) had a higher American Society of Anesthesiologists score (AOR: 1.29, P < .2) and had a higher rate of emergent operation (AOR: 1.40, P < .01). CONCLUSIONS: Overall, 10.8% of patients undergoing colectomy for colon cancer have metastatic disease. Postoperative morbidity and mortality are significantly higher than in patients with localized disease. Published by Elsevier Inc.
BACKGROUND:Patients with advanced colorectal cancer have a high incidence of postoperative complications. We sought to identify outcomes of patients who underwent resection for colon cancer by cancer stage. METHODS: The National Surgical Quality Improvement Program database was used to evaluate all patients who underwent colon resection with a diagnosis of colon cancer from 2012 to 2014. Multivariate logistic regression analysis was performed to investigate patient outcomes by cancer stage. RESULTS: A total of 7,786 colon cancerpatients who underwent colon resection were identified. Of these, 10.8% had metastasis at the time of operation. Patients with metastatic disease had significantly increased risks of perioperative morbidity (adjusted odds ratio [AOR]: 1.44, P = .01) and mortality (AOR: 3.72, P = .01). Patients with metastatic disease were significantly younger (AOR: .99, P < .01) had a higher American Society of Anesthesiologists score (AOR: 1.29, P < .2) and had a higher rate of emergent operation (AOR: 1.40, P < .01). CONCLUSIONS: Overall, 10.8% of patients undergoing colectomy for colon cancer have metastatic disease. Postoperative morbidity and mortality are significantly higher than in patients with localized disease. Published by Elsevier Inc.
Entities:
Keywords:
Colon cancer; Disseminated cancer; Metastatic colon cancer
Authors: Ryan Lamm; Steven N Mathews; Jie Yang; Jihye Park; Mark Talamini; Aurora D Pryor; Dana Telem Journal: J Gastrointest Surg Date: 2017-03-15 Impact factor: 3.452
Authors: Alaina Garbens; Christopher J D Wallis; Georg Bjarnason; Girish S Kulkarni; Avery B Nathens; Robert K Nam; Raj Satkunasivam Journal: Can Urol Assoc J Date: 2017-11 Impact factor: 1.862
Authors: Riccardo Lemini; Kristopher Attwood; Tariq Almerey; Jinny Gunn; Tamanie E Yeager; Alexandra W Elias; Kristin Partain; Matthew S Jorgensen; Wenyan Ji; Emmanuel M Gabriel; Dorin T Colibaseanu Journal: J Gastrointest Oncol Date: 2019-12