María Sierra Girón-Prieto1, María Del Carmen Cano-García2, Miguel Ángel Arrabal-Polo3, Antonio Poyatos-Andujar4, Miguel Quesada-Charneco5, Tomás de Haro-Muñoz6, Salvador Arias-Santiago7, Miguel Arrabal-Martín8. 1. Primary Care, Health Centre of Pinos Puente, Programa de Doctorado de Medicina Clínica y Salud Pública, Granada University, Granada, Spain. 2. Institute IBS Granada, Plaza Ciudad de los Cármenes, No. 4, Granada, Spain. 3. Institute IBS Granada, Plaza Ciudad de los Cármenes, No. 4, Granada, Spain. arrabalp@ono.com. 4. Biochemical Department, Santa Ana Hospital, Granada, Spain. 5. Endocrinology Department, Granada University Hospital, Granada, Spain. 6. Biochemical Department, Granada University Hospital, Granada, Spain. 7. Medicine Department, Granada University, Granada, Spain. 8. Surgery Department, Institute IBS Granada, Granada University, Granada, Spain.
Abstract
PURPOSE: The aim of this study is to analyse the percentage of hypovitaminosis D, as well as its relationship with the various parameters of calcium-phosphate metabolism. METHODS: A case control study was conducted on 366 patients, divided into two groups: Group 1: 127 non-stone-forming patients, and Group 2: 239 calcium stone forming. A study was performed on calcium-phosphate metabolism and urinary lithogenic factors. The percentage of vitamin D deficiency (25-OH-vitamin D levels <20 ng/ml) between the groups was analysed and compared. The SPSS 20.0 statistics program was used for the analysis, with a p ≤ .05 being considered significant. RESULTS: The mean age of Group 1 was 52.1 years compared to 49.6 years in Group 2, with no significant differences (p = .07). Vitamin D levels were lower in Group 2 compared to Group 1 (25.7 vs. 28.4 ng/ml, p = .02). A vitamin D deficiency was observed in 28 % of the Group 2 stone-forming patients versus 15.7 % in Group 1 (p = .009), with an odds ratio (OR) of 2.09 (95 % CI; 1.19-3.63). In the stone-forming patients with a vitamin D deficiency, the only difference observed was the higher levels of iPTH compared to those stone-formers with a normal vitamin D (56.9 vs. 45.5 pg/ml, respectively; p = .0001). CONCLUSION: Calcium stone-forming patients have lower mean levels of vitamin D and a higher percentage of hypovitaminosis D than in non-stone-forming patients. This was only related to increased iPTH levels, with urine calcium and other lithogenic parameters having no obvious effect.
PURPOSE: The aim of this study is to analyse the percentage of hypovitaminosis D, as well as its relationship with the various parameters of calcium-phosphate metabolism. METHODS: A case control study was conducted on 366 patients, divided into two groups: Group 1: 127 non-stone-forming patients, and Group 2: 239 calcium stone forming. A study was performed on calcium-phosphate metabolism and urinary lithogenic factors. The percentage of vitamin D deficiency (25-OH-vitamin D levels <20 ng/ml) between the groups was analysed and compared. The SPSS 20.0 statistics program was used for the analysis, with a p ≤ .05 being considered significant. RESULTS: The mean age of Group 1 was 52.1 years compared to 49.6 years in Group 2, with no significant differences (p = .07). Vitamin D levels were lower in Group 2 compared to Group 1 (25.7 vs. 28.4 ng/ml, p = .02). A vitamin D deficiency was observed in 28 % of the Group 2 stone-forming patients versus 15.7 % in Group 1 (p = .009), with an odds ratio (OR) of 2.09 (95 % CI; 1.19-3.63). In the stone-forming patients with a vitamin D deficiency, the only difference observed was the higher levels of iPTH compared to those stone-formers with a normal vitamin D (56.9 vs. 45.5 pg/ml, respectively; p = .0001). CONCLUSION:Calcium stone-forming patients have lower mean levels of vitamin D and a higher percentage of hypovitaminosis D than in non-stone-forming patients. This was only related to increased iPTH levels, with urine calcium and other lithogenic parameters having no obvious effect.
Entities:
Keywords:
Calcium; Calcium stones; Metabolism; Phosphorus; Vitamin D deficiency
Authors: David E Leaf; Ruslan Korets; Eric N Taylor; Jie Tang; John R Asplin; David S Goldfarb; Mantu Gupta; Gary C Curhan Journal: Clin J Am Soc Nephrol Date: 2012-03-15 Impact factor: 8.237
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