Literature DB >> 27093944

Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes.

John J G Tesmer1.   

Abstract

A revolution in the analysis of seven transmembrane domain (7TM) receptors has provided detailed information about how these physiologically important signalling proteins interact with extracellular cues. However, it has proved much more challenging to understand how 7TM receptors convey information to their principal intracellular targets: heterotrimeric G proteins, G protein-coupled receptor kinases and arrestins. Recent structures now suggest a common mechanism that enables these structurally diverse cytoplasmic proteins to 'hitch a ride' on hundreds of different activated 7TM receptors in order to instigate physiological change.

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Year:  2016        PMID： 27093944      PMCID： PMC5503103          DOI： 10.1038/nrm.2016.36

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  110 in total

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Journal:  Nat Struct Mol Biol       Date:  2006-08-06       Impact factor: 15.369

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5.  Serial femtosecond crystallography of G protein-coupled receptors.

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Journal:  Science       Date:  2013-12-20       Impact factor: 47.728

6.  Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization.

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Review 7.  Opioid receptors: Structural and mechanistic insights into pharmacology and signaling.

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Journal:  Eur J Pharmacol       Date:  2015-05-14       Impact factor: 4.432

8.  Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.

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9.  Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

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10.  Structure and function of an irreversible agonist-β(2) adrenoceptor complex.

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Journal:  Nature       Date:  2011-01-13       Impact factor: 49.962
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  14 in total

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Review 3.  Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia.

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Review 5.  Apelinergic System Structure and Function.

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6.  Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe.

Authors:  Tyler S Beyett; Amy E Fraley; Emily Labudde; Dhabaleswar Patra; Ryan C Coleman; Akito Eguchi; Alisa Glukhova; Qiuyan Chen; Robert M Williams; Walter J Koch; David H Sherman; John J G Tesmer
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8.  Novel fluorescent GPCR biosensor detects retinal equilibrium binding to opsin and active G protein and arrestin signaling conformations.

Authors:  Christopher T Schafer; Anthony Shumate; David L Farrens
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Review 9.  Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding.

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