BACKGROUND: The clinical and neurobiological underpinnings of transient nonmotor (TNM) psychiatric symptoms during the optimization of stimulation parameters in the course of subthalamic nucleus deep brain stimulation (STN-DBS) remain under intense investigation. METHODS: Forty-nine patients with refractory Parkinson's disease underwent bilateral STN-DBS implants and were enrolled in a 24-week prospective, naturalistic follow-up study. Patients who exhibited TNM psychiatric manifestations during DBS parameter optimization were evaluated for potential associations with clinical outcome measures. RESULTS: Twenty-nine TNM+ episodes were reported by 15 patients. No differences between TNM+ and TNM- groups were found in motor outcome. However, unlike the TNM- group, TNM+ patients did not report improvement in subsyndromal depression or quality of life. TNM+ episodes were more likely to emerge during bilateral monopolar stimulation of the medial STN. CONCLUSIONS: The occurrence of TNM psychiatric symptoms during optimization of stimulation parameters was associated with the persistence of subsyndromal depression and with lower quality of life ratings at 6 months. The neurobiological underpinnings of TNM symptoms are investigated yet remain difficult to explain.
BACKGROUND: The clinical and neurobiological underpinnings of transient nonmotor (TNM) psychiatric symptoms during the optimization of stimulation parameters in the course of subthalamic nucleus deep brain stimulation (STN-DBS) remain under intense investigation. METHODS: Forty-nine patients with refractory Parkinson's disease underwent bilateral STN-DBS implants and were enrolled in a 24-week prospective, naturalistic follow-up study. Patients who exhibited TNM psychiatric manifestations during DBS parameter optimization were evaluated for potential associations with clinical outcome measures. RESULTS: Twenty-nine TNM+ episodes were reported by 15 patients. No differences between TNM+ and TNM- groups were found in motor outcome. However, unlike the TNM- group, TNM+ patients did not report improvement in subsyndromal depression or quality of life. TNM+ episodes were more likely to emerge during bilateral monopolar stimulation of the medial STN. CONCLUSIONS: The occurrence of TNM psychiatric symptoms during optimization of stimulation parameters was associated with the persistence of subsyndromal depression and with lower quality of life ratings at 6 months. The neurobiological underpinnings of TNM symptoms are investigated yet remain difficult to explain.
Authors: M Sensi; R Eleopra; M A Cavallo; E Sette; P Milani; R Quatrale; J G Capone; V Tugnoli; M R Tola; E Granieri; P G Data Journal: Parkinsonism Relat Disord Date: 2004-06 Impact factor: 4.891
Authors: Kendall H Lee; Charles D Blaha; Paul A Garris; Pedram Mohseni; April E Horne; Kevin E Bennet; Filippo Agnesi; Jonathan M Bledsoe; Deranda B Lester; Chris Kimble; Hoon-Ki Min; Young-Bo Kim; Zang-Hee Cho Journal: Neuromodulation Date: 2009-04
Authors: Michael S Okun; Samuel S Wu; Sarah Fayad; Herbert Ward; Dawn Bowers; Christian Rosado; Lauren Bowen; Charles Jacobson; Christopher Butson; Kelly D Foote Journal: PLoS One Date: 2014-12-03 Impact factor: 3.240
Authors: Volker A Coenen; Bettina H Bewernick; Sarah Kayser; Hannah Kilian; Jan Boström; Susanne Greschus; René Hurlemann; Margaretha Eva Klein; Susanne Spanier; Bastian Sajonz; Horst Urbach; Thomas E Schlaepfer Journal: Neuropsychopharmacology Date: 2019-03-13 Impact factor: 7.853