Cecilia Gómez-Santos1, Cristina Bandín Saura, J A Ros Lucas, Pedro Castell, Juan A Madrid, Marta Garaulet. 1. 1Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain 2Universidad Autónoma de Chile, Santiago de Chile, Chile 3IMIB-Arrixaca, Murcia, Spain 4Neumology Service of Hospital Virgen de Arrixaca, Murcia, Spain 5Instrumentation Service Psychological, University of Murcia, Murcia, Spain.
Abstract
OBJECTIVE: The aim of the study was to investigate whether postmenopausal women show differences in circadian-related variables and sleep characteristics compared with premenopausal women, and to analyze potential associations between these circadian-related variables and abdominal fat distribution or metabolic syndrome (MetS) components. METHODS: A total of 177 women were studied (127 premenopausal, 50 postmenopausal). Sixty percent of the total population was overweight/obese, with no significant differences between premenopausal (60%) and postmenopausal women (62%) (P = 0.865). Wrist temperature (WT) and rest-activity cycles were measured during 8 consecutive days, and sleep and food diaries collected. MetS characteristics and daily patterns of saliva cortisol were analyzed. Sleep characteristics were assessed with domiciliary polysomnography. RESULTS: Postmenopausal women showed a less robust rhythm in WT with lower amplitude (°C) (0.8 ± 0.4 vs 0.9 ± 0.5) (P < 0.05) and lower mean temperature values at the midpoint of sleep than premenopausal women. Postmenopausal women were also more morning-type than premenopausal women, showing a phase advance of approximately 1 hour in WT and rest-activity rhythms, and more morning-type habits (earlier sleep onset/offset and breakfast intake) (P < 0.05). Postmenopausal women showed higher levels of activity in the morning and lower in the evening compared with premenopausal women (P < 0.05). Daily variability in cortisol was significantly reduced in postmenopausal women compared with premenopausal women (P < 0.05). Postmenopausal women had increased frequency of sleep-related breathing abnormalities (P < 0.0001). In the women studied, abdominal fat and MetS were associated with an increase in circadian alterations (high fragmentation and low amplitude of the rhythm) (P < 0.05). CONCLUSIONS: Postmenopausal women exhibit loss of circadian robustness and an increase in sleep abnormalities compared with premenopausal women.
OBJECTIVE: The aim of the study was to investigate whether postmenopausal women show differences in circadian-related variables and sleep characteristics compared with premenopausal women, and to analyze potential associations between these circadian-related variables and abdominal fat distribution or metabolic syndrome (MetS) components. METHODS: A total of 177 women were studied (127 premenopausal, 50 postmenopausal). Sixty percent of the total population was overweight/obese, with no significant differences between premenopausal (60%) and postmenopausal women (62%) (P = 0.865). Wrist temperature (WT) and rest-activity cycles were measured during 8 consecutive days, and sleep and food diaries collected. MetS characteristics and daily patterns of saliva cortisol were analyzed. Sleep characteristics were assessed with domiciliary polysomnography. RESULTS: Postmenopausal women showed a less robust rhythm in WT with lower amplitude (°C) (0.8 ± 0.4 vs 0.9 ± 0.5) (P < 0.05) and lower mean temperature values at the midpoint of sleep than premenopausal women. Postmenopausal women were also more morning-type than premenopausal women, showing a phase advance of approximately 1 hour in WT and rest-activity rhythms, and more morning-type habits (earlier sleep onset/offset and breakfast intake) (P < 0.05). Postmenopausal women showed higher levels of activity in the morning and lower in the evening compared with premenopausal women (P < 0.05). Daily variability in cortisol was significantly reduced in postmenopausal women compared with premenopausal women (P < 0.05). Postmenopausal women had increased frequency of sleep-related breathing abnormalities (P < 0.0001). In the women studied, abdominal fat and MetS were associated with an increase in circadian alterations (high fragmentation and low amplitude of the rhythm) (P < 0.05). CONCLUSIONS: Postmenopausal women exhibit loss of circadian robustness and an increase in sleep abnormalities compared with premenopausal women.
Authors: T Ruiz-Lozano; J Vidal; A de Hollanda; M Canteras; M Garaulet; M Izquierdo-Pulido Journal: Int J Obes (Lond) Date: 2016-06-24 Impact factor: 5.095
Authors: Erica C Jansen; Dalia Stern; Adriana Monge; Louise M O'Brien; Martin Lajous; Karen E Peterson; Ruy López-Ridaura Journal: J Clin Sleep Med Date: 2020-08-15 Impact factor: 4.062
Authors: Symielle A Gaston; Yong-Moon Park; Ketrell L McWhorter; Dale P Sandler; Chandra L Jackson Journal: Diabetol Metab Syndr Date: 2019-02-14 Impact factor: 3.320
Authors: Hyeyun Kim; Jayoung Kim; Hyo Jin Ju; Bong Jin Jang; Tae Kyu Wang; Yeong In Kim Journal: Int J Environ Res Public Health Date: 2020-09-09 Impact factor: 3.390