Josephine Mauskopf1, Andrea V Margulis, Miny Samuel, Kathleen N Lohr. 1. From the *RTI Health Solutions and §RTI International, Research Triangle Park, North Carolina; †RTI Health Solutions, Barcelona, Spain; ‡RTI Health Solutions, Manchester, England.
Abstract
BACKGROUND: Studies have explored the risk for and impact of respiratory syncytial virus (RSV) infection requiring hospitalization among healthy preterm infants born at 29-35 weeks of gestational age not given RSV immunoprophylaxis. We performed a systematic review and qualitative synthesis of these studies. METHODS: Two experienced reviewers used prespecified inclusion/exclusion criteria to screen titles/abstracts and full-text studies using MEDLINE, Embase, BIOSIS and Cochrane Library (January 1, 1985, to November 6, 2014). We abstracted data on risk factors for RSV hospitalization, incidence and short- and long-term outcomes of RSV hospitalization. Using standard procedures, we assessed study risk of bias and graded strength of evidence (SOE). RESULTS: We identified 4754 records and reviewed 27. Important risk factors for RSV hospitalization included young age during the RSV season, having school-age siblings and day-care attendance, with odds ratios >2.5 in at least one study (high SOE). Incidence rates for RSV hospitalizations ranged from 2.3% to 10% (low SOE). Length of hospital stays ranged from 3.8 to 6.1 days (low SOE). Recurrent wheezing rates ranged from 20.7% to 42.8% 1 to 2 years after RSV hospitalization (low SOE). CONCLUSIONS: Young chronological age and some environmental risk factors are important clinical indicators of an increased risk of RSV hospitalization in healthy preterm infants 32 to 35 weeks of gestational age. SOE was low for estimates of incidence of RSV hospitalizations, in-hospital resource use and recurrent wheezing in this population. Studies were inconsistent in study characteristics, including weeks of gestational age, age during RSV season and control for confounding factors.
BACKGROUND: Studies have explored the risk for and impact of respiratory syncytial virus (RSV) infection requiring hospitalization among healthy preterm infants born at 29-35 weeks of gestational age not given RSV immunoprophylaxis. We performed a systematic review and qualitative synthesis of these studies. METHODS: Two experienced reviewers used prespecified inclusion/exclusion criteria to screen titles/abstracts and full-text studies using MEDLINE, Embase, BIOSIS and Cochrane Library (January 1, 1985, to November 6, 2014). We abstracted data on risk factors for RSV hospitalization, incidence and short- and long-term outcomes of RSV hospitalization. Using standard procedures, we assessed study risk of bias and graded strength of evidence (SOE). RESULTS: We identified 4754 records and reviewed 27. Important risk factors for RSV hospitalization included young age during the RSV season, having school-age siblings and day-care attendance, with odds ratios >2.5 in at least one study (high SOE). Incidence rates for RSV hospitalizations ranged from 2.3% to 10% (low SOE). Length of hospital stays ranged from 3.8 to 6.1 days (low SOE). Recurrent wheezing rates ranged from 20.7% to 42.8% 1 to 2 years after RSV hospitalization (low SOE). CONCLUSIONS: Young chronological age and some environmental risk factors are important clinical indicators of an increased risk of RSV hospitalization in healthy preterm infants 32 to 35 weeks of gestational age. SOE was low for estimates of incidence of RSV hospitalizations, in-hospital resource use and recurrent wheezing in this population. Studies were inconsistent in study characteristics, including weeks of gestational age, age during RSV season and control for confounding factors.
Authors: Shawn L Ralston; Allan S Lieberthal; H Cody Meissner; Brian K Alverson; Jill E Baley; Anne M Gadomski; David W Johnson; Michael J Light; Nizar F Maraqa; Eneida A Mendonca; Kieran J Phelan; Joseph J Zorc; Danette Stanko-Lopp; Mark A Brown; Ian Nathanson; Elizabeth Rosenblum; Stephen Sayles; Sinsi Hernandez-Cancio Journal: Pediatrics Date: 2014-11 Impact factor: 7.124
Authors: Johannes G Liese; Eva Grill; Birgit Fischer; Irmgard Roeckl-Wiedmann; David Carr; Bernd H Belohradsky Journal: Eur J Pediatr Date: 2003-03-01 Impact factor: 3.183
Authors: Barbara J Law; Joanne M Langley; Upton Allen; Bosco Paes; David S C Lee; Ian Mitchell; John Sampalis; Hervé Walti; Joan Robinson; Karel O'Brien; Carina Majaesic; Georges Caouette; Lyne Frenette; Nicole Le Saux; Brian Simmons; Sharon Moisiuk; Koravanagattu Sankaran; Cecil Ojah; Avash J Singh; Marc H Lebel; Godfrey S Bacheyie; Heather Onyett; Andrea Michaliszyn; Patricia Manzi; Diana Parison Journal: Pediatr Infect Dis J Date: 2004-09 Impact factor: 2.129
Authors: J-B Gouyon; J-C Rozé; C Guillermet-Fromentin; I Glorieux; L Adamon; M DI Maio; T Miloradovich; D Anghelescu; D Pinquier; B Escande; C Elleau Journal: Epidemiol Infect Date: 2012-06-15 Impact factor: 4.434
Authors: M Cetinkaya; T K Oral; S Karatekin; B Cebeci; A Babayigit; Y Yesil Journal: Eur J Clin Microbiol Infect Dis Date: 2017-04-08 Impact factor: 3.267
Authors: Nienke M Scheltema; Angela Gentile; Florencia Lucion; D James Nokes; Patrick K Munywoki; Shabir A Madhi; Michelle J Groome; Cheryl Cohen; Jocelyn Moyes; Kentigern Thorburn; Somsak Thamthitiwat; Hitoshi Oshitani; Socorro P Lupisan; Aubree Gordon; José F Sánchez; Katherine L O'Brien; Bradford D Gessner; Agustinus Sutanto; Asuncion Mejias; Octavio Ramilo; Najwa Khuri-Bulos; Natasha Halasa; Fernanda de-Paris; Márcia Rosane Pires; Michael C Spaeder; Bosco A Paes; Eric A F Simões; Ting F Leung; Maria Tereza da Costa Oliveira; Carla Cecília de Freitas Lázaro Emediato; Quique Bassat; Warwick Butt; Hsin Chi; Uzma Bashir Aamir; Asad Ali; Marilla G Lucero; Rodrigo A Fasce; Olga Lopez; Barbara A Rath; Fernando P Polack; Jesse Papenburg; Srđan Roglić; Hisato Ito; Edward A Goka; Diederick E Grobbee; Harish Nair; Louis J Bont Journal: Lancet Glob Health Date: 2017-10 Impact factor: 26.763
Authors: Natalia Olchanski; Ryan N Hansen; Elle Pope; Brittany D'Cruz; Jaime Fergie; Mitchell Goldstein; Leonard R Krilov; Kimmie K McLaurin; Barbara Nabrit-Stephens; Gerald Oster; Kenneth Schaecher; Fadia T Shaya; Peter J Neumann; Sean D Sullivan Journal: Open Forum Infect Dis Date: 2018-02-07 Impact factor: 3.835
Authors: Josep Figueras-Aloy; Paolo Manzoni; Bosco Paes; Eric A F Simões; Louis Bont; Paul A Checchia; Brigitte Fauroux; Xavier Carbonell-Estrany Journal: Infect Dis Ther Date: 2016-09-14
Authors: Rohan C Parikh; Kimmie K McLaurin; Andrea V Margulis; Josephine Mauskopf; Christopher S Ambrose; Melissa Pavilack; Sean D Candrilli Journal: Infect Dis Ther Date: 2017-09-02
Authors: Amanda M Kong; Leonard R Krilov; Jaime Fergie; Mitchell Goldstein; David Diakun; Sally W Wade; Melissa Pavilack; Kimmie K McLaurin Journal: Am J Perinatol Date: 2017-09-07 Impact factor: 1.862