Literature DB >> 27092798

PP2A's restraint of mTOR is critical for T(reg) cell activity.

Greg M Delgoffe1.   

Abstract

Entities:  

Mesh：

Year:  2016        PMID： 27092798     DOI： 10.1038/ni.3442

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


× No keyword cloud information.
  11 in total

1.  Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells.

Authors:  Natasha K Crellin; Rosa V Garcia; Megan K Levings
Journal:  Blood       Date:  2006-10-24       Impact factor: 22.113

2.  The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.

Authors:  Greg M Delgoffe; Thomas P Kole; Yan Zheng; Paul E Zarek; Krystal L Matthews; Bo Xiao; Paul F Worley; Sara C Kozma; Jonathan D Powell
Journal:  Immunity       Date:  2009-06-19       Impact factor: 31.745

Review 3.  Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.

Authors:  Parthasarathy Seshacharyulu; Poomy Pandey; Kaustubh Datta; Surinder K Batra
Journal:  Cancer Lett       Date:  2013-02-20       Impact factor: 8.679

Review 4.  Phenotypical and functional specialization of FOXP3+ regulatory T cells.

Authors:  Daniel J Campbell; Meghan A Koch
Journal:  Nat Rev Immunol       Date:  2011-02       Impact factor: 53.106

Review 5.  Integrating canonical and metabolic signalling programmes in the regulation of T cell responses.

Authors:  Kristen N Pollizzi; Jonathan D Powell
Journal:  Nat Rev Immunol       Date:  2014-07       Impact factor: 53.106

6.  Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.

Authors:  Sharad Shrestha; Kai Yang; Cliff Guy; Peter Vogel; Geoffrey Neale; Hongbo Chi
Journal:  Nat Immunol       Date:  2015-01-05       Impact factor: 25.606

7.  mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function.

Authors:  Hu Zeng; Kai Yang; Caryn Cloer; Geoffrey Neale; Peter Vogel; Hongbo Chi
Journal:  Nature       Date:  2013-06-30       Impact factor: 49.962

8.  Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

Authors:  Greg M Delgoffe; Seng-Ryong Woo; Meghan E Turnis; David M Gravano; Cliff Guy; Abigail E Overacre; Matthew L Bettini; Peter Vogel; David Finkelstein; Jody Bonnevier; Creg J Workman; Dario A A Vignali
Journal:  Nature       Date:  2013-08-04       Impact factor: 49.962

9.  Phosphatase PP2A is requisite for the function of regulatory T cells.

Authors:  Sokratis A Apostolidis; Noé Rodríguez-Rodríguez; Abel Suárez-Fueyo; Nikolina Dioufa; Esra Ozcan; José C Crispín; Maria G Tsokos; George C Tsokos
Journal:  Nat Immunol       Date:  2016-03-14       Impact factor: 25.606

10.  The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment.

Authors:  Madhav D Sharma; Rahul Shinde; Tracy L McGaha; Lei Huang; Rikke B Holmgaard; Jedd D Wolchok; Mario R Mautino; Esteban Celis; Arlene H Sharpe; Loise M Francisco; Jonathan D Powell; Hideo Yagita; Andrew L Mellor; Bruce R Blazar; David H Munn
Journal:  Sci Adv       Date:  2015-11-06       Impact factor: 14.136
View more
  6 in total

1.  ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.

Authors:  Feixiang Wang; Yuerong Zhang; Xiaoyan Yu; Xiao-Lu Teng; Rui Ding; Zhilin Hu; Aiting Wang; Zhengting Wang; Youqiong Ye; Qiang Zou
Journal:  J Clin Invest       Date:  2021-10-01       Impact factor: 14.808

2.  Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy.

Authors:  Matthew J Justice; Irina Bronova; Kelly S Schweitzer; Christophe Poirier; Janice S Blum; Evgeny V Berdyshev; Irina Petrache
Journal:  J Lipid Res       Date:  2018-01-29       Impact factor: 5.922

Review 3.  Treg Destabilization and Reprogramming: Implications for Cancer Immunotherapy.

Authors:  David H Munn; Madhav D Sharma; Theodore S Johnson
Journal:  Cancer Res       Date:  2018-09-04       Impact factor: 12.701

4.  Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade.

Authors:  Winson S Ho; Herui Wang; Dominic Maggio; John S Kovach; Qi Zhang; Qi Song; Francesco M Marincola; John D Heiss; Mark R Gilbert; Rongze Lu; Zhengping Zhuang
Journal:  Nat Commun       Date:  2018-05-29       Impact factor: 14.919

5.  Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response.

Authors:  Yu-Ting Yen; May Chien; Pei-Yi Wu; Chi-Chang Ho; Chun-Te Ho; Kevin Chih-Yang Huang; Shu-Fen Chiang; K S Clifford Chao; William Tzu-Liang Chen; Shih-Chieh Hung
Journal:  Nat Commun       Date:  2021-12-15       Impact factor: 17.694

Review 6.  Opioids and Vitamin C: Known Interactions and Potential for Redox-Signaling Crosstalk.

Authors:  Mackenzie Newman; Heather Connery; Jonathan Boyd
Journal:  Antioxidants (Basel)       Date:  2022-06-27
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.