Jarle Jortveit1, Elisabeth Leirgul2, Leif Eskedal3, Gottfried Greve4, Tatiana Fomina5, Gaute Døhlen6, Grethe S Tell7, Sigurd Birkeland8, Nina Øyen9, Henrik Holmstrøm10. 1. Department of Cardiology, Sørlandet, Arendal, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 2. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. 3. Department of Research, Sørlandet Hospital, Kristiansand, Norway. 4. Department of Heart Disease, Haukeland University Hospital, Bergen, Norway Department of Medical Science, University of Bergen, Bergen, Norway. 5. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. 6. Women's and Children's Department, Oslo University Hospital, Oslo, Norway. 7. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway Division of epidemiology, Norwegian Institute of Public Health, Bergen, Norway. 8. Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway. 9. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. 10. Institute of Clinical Medicine, University of Oslo, Oslo, Norway Women's and Children's Department, Oslo University Hospital, Oslo, Norway.
Abstract
BACKGROUND: Ventricular septal defects (VSDs) are the most common congenital heart defects (CHDs). Previous studies indicate an increased risk of endocarditis, aortic regurgitation, left ventricular outflow tract obstructions, pulmonary hypertension, arrhythmias and sudden death in patients with isolated VSDs. The present nationwide cohort study reports mortality and cardiac complications requiring hospitalisation or intervention in children with isolated VSDs. METHODS AND RESULTS: Medical information concerning all 943 871 live births in Norway in 1994-2009 was retrieved from the Medical Birth Registry of Norway, the Cardiovascular Disease in Norway project, the Oslo University Hospital's Clinical Registry of Congenital Heart Defects and the Norwegian Cause of Death Registry. Isolated VSDs were identified in 3495 children without known chromosomal aberrations or extracardiac malformations. Surgical or catheter-based treatment of VSD was performed in 181 (5.2%) cases. Twelve (0.3%) children with VSDs died before 2013. There was no operative mortality, and no excess mortality in children with isolated VSDs compared with children without VSDs (adjusted HR 0.8 (0.5 to 1.4), p=0.48). The following conditions were recorded as possible cardiac complications of the VSDs: endocarditis in 3 children (0.9‰), aortic regurgitation in 12 children (3.4‰), left ventricular outflow tract obstructions in no children (0.0‰), pulmonary hypertension in 1 child (0.3‰) and arrhythmias in 16 children (4.6‰). CONCLUSIONS: The entire group of children with isolated VSDs had a favourable prognosis without excess mortality. Cardiac complications requiring hospitalisation or intervention, including endocarditis, aortic regurgitation, left ventricular outflow tract obstructions, pulmonary hypertension and arrhythmias, were infrequent during childhood. TRIAL REGISTRATION NUMBER: NCT02026557. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
BACKGROUND:Ventricular septal defects (VSDs) are the most common congenital heart defects (CHDs). Previous studies indicate an increased risk of endocarditis, aortic regurgitation, left ventricular outflow tract obstructions, pulmonary hypertension, arrhythmias and sudden death in patients with isolated VSDs. The present nationwide cohort study reports mortality and cardiac complications requiring hospitalisation or intervention in children with isolated VSDs. METHODS AND RESULTS: Medical information concerning all 943 871 live births in Norway in 1994-2009 was retrieved from the Medical Birth Registry of Norway, the Cardiovascular Disease in Norway project, the Oslo University Hospital's Clinical Registry of Congenital Heart Defects and the Norwegian Cause of Death Registry. Isolated VSDs were identified in 3495 children without known chromosomal aberrations or extracardiac malformations. Surgical or catheter-based treatment of VSD was performed in 181 (5.2%) cases. Twelve (0.3%) children with VSDs died before 2013. There was no operative mortality, and no excess mortality in children with isolated VSDs compared with children without VSDs (adjusted HR 0.8 (0.5 to 1.4), p=0.48). The following conditions were recorded as possible cardiac complications of the VSDs: endocarditis in 3 children (0.9‰), aortic regurgitation in 12 children (3.4‰), left ventricular outflow tract obstructions in no children (0.0‰), pulmonary hypertension in 1 child (0.3‰) and arrhythmias in 16 children (4.6‰). CONCLUSIONS: The entire group of children with isolated VSDs had a favourable prognosis without excess mortality. Cardiac complications requiring hospitalisation or intervention, including endocarditis, aortic regurgitation, left ventricular outflow tract obstructions, pulmonary hypertension and arrhythmias, were infrequent during childhood. TRIAL REGISTRATION NUMBER: NCT02026557. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Authors: Adam M Butensky; Alexandra Channing; Andrew S Handel; David Kalfa; Stuart Holzer Journal: Pediatr Cardiol Date: 2022-06-03 Impact factor: 1.838
Authors: Mads Damkjaer; Stine Kjaer Urhoj; Joachim Tan; Gillian Briggs; Maria Loane; Joanne Emma Given; Laia Barrachina-Bonet; Clara Cavero-Carbonell; Alessio Coi; Amanda J Neville; Anna Heino; Sonja Kiuru-Kuhlefelt; Susan Jordan; Ieuan Scanlon; Anna Pierini; Aurora Puccini; Ester Garne; Joan K Morris Journal: BMJ Open Date: 2022-04-21 Impact factor: 3.006