Andrew H Kemp1, Santiago Rodríguez López2, Valeria M A Passos3, Marcio S Bittencourt4, Eduardo M Dantas5, José G Mill6, Antonio L P Ribeiro7, Julian F Thayer8, Isabela M Bensenor4, Paulo A Lotufo4. 1. University Hospital and Faculty of Medicine, University of São Paulo, São Paulo, Brazil; School of Psychology & Discipline of Psychiatry, University of Sydney, Sydney, Australia. Electronic address: a.h.kemp@swansea.ac.uk. 2. University Hospital and Faculty of Medicine, University of São Paulo, São Paulo, Brazil; Department of Biology, Universidad Autónoma de Madrid, Spain. 3. Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 4. University Hospital and Faculty of Medicine, University of São Paulo, São Paulo, Brazil. 5. Collegiate of Biological Sciences, Federal University of Vale do São Francisco, Petrolina, Pernambuco, Brazil. 6. Departament of Physiological Sciences, Federal University of Espírito Santo, Vitória, Brasil, Brazil. 7. Hospital das Clínicas and Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil. 8. Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH, 43210, USA.
Abstract
BACKGROUND: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. METHODS: Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N=8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). RESULTS AND CONCLUSIONS: Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a 'spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment.
BACKGROUND: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. METHODS: Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N=8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). RESULTS AND CONCLUSIONS:Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a 'spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment.
Authors: Francesco Vadini; Paola G Simeone; Andrea Boccatonda; Maria T Guagnano; Rossella Liani; Romina Tripaldi; Augusto Di Castelnuovo; Francesco Cipollone; Agostino Consoli; Francesca Santilli Journal: Int J Obes (Lond) Date: 2020-01-21 Impact factor: 5.095
Authors: Carolina Abulafia; Bárbara Duarte-Abritta; Mirta F Villarreal; María S Ladrón-de-Guevara; Celeste García; Geraldine Sequeyra; Gustavo Sevlever; Leticia Fiorentini; Karl-Jürgen Bär; Deborah R Gustafson; Daniel E Vigo; Salvador M Guinjoan Journal: Front Aging Neurosci Date: 2017-04-05 Impact factor: 5.750