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Literature DB >> 2709064

Analysis of oligoclonal antibody bands against individual HIV structural proteins in the CSF of patients infected with HIV.

R Kaiser¹, R Dörries, W Lüer, S Poser, H D Pohle, K Felgenhauer, V ter Meulen.

Abstract

Intrathecal antibody responses to HIV were investigated by a highly sensitive immunoblot assay. Serum and CSF specimens were tested for reactivity with the recombinant HIV gag proteins p15, p17 and p24 and with the recombinant transmembrane protein p41. Autochthonous production of virus-specific IgG to one or more HIV structural proteins was seen in 8 of 10 asymptomatic seropositive subjects, in 3 of 4 men with AIDS-related complex, and in 9 of 13 patients with AIDS. These results were consonant with an elevated CSF/serum antibody ratio to total HIV antigen. The high frequency of local HIV-specific antibody synthesis in seropositive individuals without related clinical symptoms indicates an early involvement of the CNS in HIV infections.

Entities: Disease Gene Species

Mesh：

Substances：
HIV Antibodies

Year: 1989 PMID： 2709064 DOI： 10.1007/BF00314332

Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849

32 in total

1. The AIDS dementia complex: I. Clinical features.

Authors: B A Navia; B D Jordan; R W Price
Journal: Ann Neurol Date: 1986-06 Impact factor: 10.422

2. HTLV-III infection in brains of children and adults with AIDS encephalopathy.

Authors: G M Shaw; M E Harper; B H Hahn; L G Epstein; D C Gajdusek; R W Price; B A Navia; C K Petito; C J O'Hara; J E Groopman
Journal: Science Date: 1985-01-11 Impact factor: 47.728

3. Acute encephalopathy coincident with seroconversion for anti-HTLV-III.

Authors: C A Carne; R S Tedder; A Smith; S Sutherland; S G Elkington; H M Daly; F E Preston; J Craske
Journal: Lancet Date: 1985-11-30 Impact factor: 79.321

4. Neurologic disease as the presenting manifestation of acquired immunodeficiency syndrome.

Authors: J R Berger; L Moskowitz; M Fischl; R E Kelley
Journal: South Med J Date: 1987-06 Impact factor: 0.954

5. The acquired immunodeficiency syndrome dementia complex as the presenting or sole manifestation of human immunodeficiency virus infection.

Authors: B A Navia; R W Price
Journal: Arch Neurol Date: 1987-01

6. Early penetration of the blood-brain-barrier by HIV.

Authors: L Resnick; J R Berger; P Shapshak; W W Tourtellotte
Journal: Neurology Date: 1988-01 Impact factor: 9.910

7. Human immunodeficiency virus infection of the brain. II. Detection of intrathecally synthesized antibodies by enzyme linked immunosorbent assay and imprint immunofixation.

Authors: F Chiodi; G Norkrans; L Hagberg; A Sönnerborg; H Gaines; S Frøland; E M Fenyö; E Norrby; B Vandvik
Journal: J Neurol Sci Date: 1988-10 Impact factor: 3.181

8. Herpes simplex virus encephalitis: intrathecal synthesis of oligoclonal virus-specific IgG, IgA and IgM antibodies.

Authors: B Vandvik; F Vartdal; E Norrby
Journal: J Neurol Date: 1982 Impact factor: 4.849

9. Intra-blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex.

Authors: L Resnick; F diMarzo-Veronese; J Schüpbach; W W Tourtellotte; D D Ho; F Müller; P Shapshak; M Vogt; J E Groopman; P D Markham
Journal: N Engl J Med Date: 1985-12-12 Impact factor: 91.245

13 in total

1. Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis.

Authors: Sabine Cepok; Dun Zhou; Rajneesh Srivastava; Stefan Nessler; Susanne Stei; Konrad Büssow; Norbert Sommer; Bernhard Hemmer
Journal: J Clin Invest Date: 2005-04-14 Impact factor: 14.808

2. Protective Humoral Immunity in the Central Nervous System Requires Peripheral CD19-Dependent Germinal Center Formation following Coronavirus Encephalomyelitis.

Authors: Jeffrey R Atkinson; Cornelia C Bergmann
Journal: J Virol Date: 2017-11-14 Impact factor: 5.103

10. IgG intrathecal synthesis in HIV-associated neurocognitive disorder (HAND) according to the HIV-1 subtypes and pattern of HIV RNA in CNS and plasma compartments.

Authors: Sergio M De Almeida; Indianara Rotta; Bin Tang; Florin Vaida; Scott Letendre; Ronald J Ellis
Journal: J Neuroimmunol Date: 2021-03-08 Impact factor: 3.221

Analysis of oligoclonal antibody bands against individual HIV structural proteins in the CSF of patients infected with HIV.

1. The AIDS dementia complex: I. Clinical features.

2. HTLV-III infection in brains of children and adults with AIDS encephalopathy.

3. Acute encephalopathy coincident with seroconversion for anti-HTLV-III.

4. Neurologic disease as the presenting manifestation of acquired immunodeficiency syndrome.

5. The acquired immunodeficiency syndrome dementia complex as the presenting or sole manifestation of human immunodeficiency virus infection.

6. Early penetration of the blood-brain-barrier by HIV.

7. Human immunodeficiency virus infection of the brain. II. Detection of intrathecally synthesized antibodies by enzyme linked immunosorbent assay and imprint immunofixation.

8. Herpes simplex virus encephalitis: intrathecal synthesis of oligoclonal virus-specific IgG, IgA and IgM antibodies.

9. Intra-blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex.

1. Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis.

2. Protective Humoral Immunity in the Central Nervous System Requires Peripheral CD19-Dependent Germinal Center Formation following Coronavirus Encephalomyelitis.

3. Postural imbalance: an early sign in HIV-1 infected patients.

4. Effects of human immunodeficiency virus encephalitis and drug abuse on the B lymphocyte population of the brain.

Review 5. Cerebrospinal fluid (CSF) analyses in HIV-1 primary neurological disease.

6. Immunoglobulin G subclass preference of intrathecally produced HIV-specific oligoclonal antibodies.

7. Progression from IgD+ IgM+ to isotype-switched B cells is site specific during coronavirus-induced encephalomyelitis.

8. Predictive value of neurological abnormalities in HIV 1 patients in the early stages of the infection.

Review 9. Intrathecal humoral immunity to encephalitic RNA viruses.

10. IgG intrathecal synthesis in HIV-associated neurocognitive disorder (HAND) according to the HIV-1 subtypes and pattern of HIV RNA in CNS and plasma compartments.